rac-(S,S)-Bis(1-ferrocenylbut-3-enyl) ether

Abstract

The title complex, [Fe2(C5H5)2(C18H20O)], formed by dehydration of 1-ferrocenylbut-3-en-1-ol, crystallizes as a racemic compound. The central C—O—C fragment, in which the C atoms are the chiral centers, is characterized by an angle of 116.26 (10)° at the O atom. One ferrocene group shows a staggered conformation whereas the other shows an eclipsed conformation.

Characterization, crystallization and preliminary X-ray crystallographic analysis of the human Uba5 C-terminus–Ufc1 complex

“…This finding indicates that Uba5 381-404 is the minimal region for Ufc1 binding, which lies at the extreme C-terminal region of Uba5. Secondary-structural prediction reveals that this region probably forms an intact -helix (Xie, 2014). Sequence analysis shows that this fragment is enriched in hydrophobic residues, which implies that the Ufc1 binding may be facilitated by hydrophobic interactions.…”

“…Atg7 recognizes Atg3 via an N-terminal domain consisting of a unique fold, which is located before the adenylation domain (Hong et al, 2011;Noda et al, 2011;Taherbhoy et al, 2011). Our previous studies showed that Uba5 57-363 is the minimal fragment necessary for highefficiency activation of Ufm1 (Xie, 2014). However, the molecular mechanism of Ufc1 recognition by Uba5 and the formation of the Ufc1-Ufm1 complex remain unknown.…”