Entrepreneurship represents the very basis of powerful societies and the essence of robust economies, bringing unique contributions to both sustainable development and economic growth processes. In addition, corporate social responsibility constitutes the key ingredient for all businesses, encouraging competitiveness, ensuring performance, and enabling excellence, while promising a safe and sustainable environment. On one hand, this chapter reviews the theory on sustainable and responsible entrepreneurship as the core of environmental and societal success, and on the other hand, it focuses on the manner in which intangible business assets and intellectual capital yield creativity, innovation, motivation, productivity, and value in challenging times (COVID-19 pandemic). This multidisciplinary study, based on quantitative and qualitative indicators, reports that intellectual capital factor plays a dominant role in constructing new products, rules, and services for the marketplace and highlights the main economic, social, and environmental effects of current business practices.