<i>Retracted:</i> Bone neoformation of a novel porous resorbable Si‐Ca‐P‐based ceramic with osteoconductive properties: physical and mechanical characterization, histological and histomorphometric study

Aza, Piedad N. De; Val, José Eduardo Maté-Sánchez de; Baudin, C.; Albacete-Martínez, Carlos Perez; Salto, A. Armijo; Calvo-Guirado, José Luís

doi:10.1111/clr.12745

Cited by 15 publications

(8 citation statements)

References 49 publications

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“…Granular entities were also found to cover the new bone more closely to the vessel (Figure 6C). This finding supports the “anchorage-dependence” theory, where cell proliferation, growth and differentiation require a substrate to adhere to it [31,32,33]. Osteoblasts must react with granular material before growing and proliferating on the HA surface.…”

Section: Discussionsupporting

confidence: 79%

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Morphological and Structural Study of a Novel Porous Nurse’s A Ceramic with Osteoconductive Properties for Tissue Engineering

et al. 2016

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The characterization process of a new porous Nurse’s A ceramic and the physico chemical nature of the remodeled interface between the implant and the surrounding bone were studied after in vivo implantation. Scaffolds were prepared by a solid-state reaction and implanted in New Zealand rabbits. Animals were sacrificed on days 15, 30, and 60. The porous biomaterial displayed biocompatible, bioresorbable, and osteoconductive capacity. The degradation processes of implants also encouraged osseous tissue ingrowths into the material’s pores, and drastically changed the macro- and microstructure of the implants. After 60 healing days, the resorption rates were 52.62% ± 1.12% for the ceramic and 47.38% ± 1.24% for the residual biomaterial. The elemental analysis showed a gradual diffusion of the Ca and Si ions from the materials into the newly forming bone during the biomaterial’s resorption process. The energy dispersive spectroscopy (EDS) analysis of the residual ceramic revealed some particle categories with different mean Ca/P ratios according to size, and indicated various resorption process stages. Since osteoconductive capacity was indicated for this material and bone ingrowth was possible, it could be applied to progressively substitute an implant.

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Section: Discussionsupporting

confidence: 79%

“…Such porosity has been reported to allow fibrovascular and bone tissue ingrowth, which have enabled direct integration with neighboring bone [31,32]. Our study also showed that the material was osteoconductive in a physiological environment.…”

Section: Discussionsupporting

confidence: 74%

Morphological and Structural Study of a Novel Porous Nurse’s A Ceramic with Osteoconductive Properties for Tissue Engineering

et al. 2016

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“…High bioactivity and adequate scaffold porosity are essential characteristics to stimulate osteoprogenitor cells and to support bone in-growth. Furthermore, resorption of the material with the same bone formation rate is required [17]. Several in vivo studies have demonstrated that Si influences bone mineralization [9,10], metabolism [18,19], collagen synthesis [20,21] and crosslinking [22].…”

Section: Discussionmentioning

confidence: 99%

Novel Resorbable and Osteoconductive Calcium Silicophosphate Scaffold Induced Bone Formation

et al. 2016

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This aim of this research was to develop a novel ceramic scaffold to evaluate the response of bone after ceramic implantation in New Zealand (NZ) rabbits. Ceramics were prepared by the polymer replication method and inserted into NZ rabbits. Macroporous scaffolds with interconnected round-shaped pores (0.5-1.5 mm = were prepared). The scaffold acted as a physical support where cells with osteoblastic capability were found to migrate, develop processes, and newly immature and mature bone tissue colonized on the surface (initially) and in the material's interior. The new ceramic induced about 62.18% ± 2.28% of new bone and almost complete degradation after six healing months. An elemental analysis showed that the gradual diffusion of Ca and Si ions from scaffolds into newly formed bone formed part of the biomaterial's resorption process. Histological and radiological studies demonstrated that this porous ceramic scaffold showed biocompatibility and excellent osteointegration and osteoinductive capacity, with no interposition of fibrous tissue between the implanted material and the hematopoietic bone marrow interphase, nor any immune response after six months of implantation. No histological changes were observed in the various organs studied (para-aortic lymph nodes, liver, kidney and lung) as a result of degradation products being released.

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“…Accordingly, materials that contain silicon, calcium and phosphorus are excellent candidates for preparing biomaterials with improved osteogenic properties [18,19,20]. The synthesis of Nurse’s A-phase (2Ca 2 SiO 4 ·Ca 3 (PO 4 ) 2 ) and silicocarnotite (Ca 2 SiO 4 ·Ca 3 (PO 4 ) 2 ) as monophasic materials, was addressed by the present authors in a previous work [21,22,23,24].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Effects of Si-Ca-P Biphasic Ceramic on the Osteogenic Differentiation of a Population of Multipotent Adult Human Stem Cells

et al. 2016

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A new type of bioceramic with osteogenic properties, suitable for hard tissue regeneration, was synthesised. The ceramic was designed and obtained in the Nurse’s A-phase-silicocarnotite subsystem. The selected composition was that corresponding to the eutectoid 28.39 wt % Nurse’s A-phase-71.61 wt % silicocarnotite invariant point. We report the effect of Nurse’s A-phase-silicocarnotite ceramic on the capacity of multipotent adult human mesenchymal stem cells (ahMSCs) cultured under experimental conditions, known to adhere, proliferate and differentiate into osteoblast lineage cells. The results at long-term culture (28 days) on the material confirmed that the undifferentiated ahMSCs cultured and in contact with the material surface adhered, spread, proliferated, and produced a mineralised extracellular matrix on the studied ceramic, and finally acquired an osteoblastic phenotype. These findings indicate that it underwent an osteoblast differentiation process. All these findings were more significant than when cells were grown on plastic, in the presence and absence of this osteogenic supplement, and were more evident when this supplement was present in the growth medium (GM). The ceramic evaluated herein was bioactive, cytocompatible and capable of promoting the proliferation and differentiation of undifferentiated ahMSCs into osteoblasts, which may be important for bone integration into the clinical setting.

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Retracted: Bone neoformation of a novel porous resorbable Si‐Ca‐P‐based ceramic with osteoconductive properties: physical and mechanical characterization, histological and histomorphometric study

Abstract: The porous calcium silicophosphate ceramic is biocompatible, partially resorbable and osteoinductive material. This rabbit study provides radiological and histological evidences confirming the suitablity of this new material for bone tissue regeneration on critical defects.

Cited by 15 publications

References 49 publications

Morphological and Structural Study of a Novel Porous Nurse’s A Ceramic with Osteoconductive Properties for Tissue Engineering

Morphological and Structural Study of a Novel Porous Nurse’s A Ceramic with Osteoconductive Properties for Tissue Engineering

Novel Resorbable and Osteoconductive Calcium Silicophosphate Scaffold Induced Bone Formation

Assessment of Effects of Si-Ca-P Biphasic Ceramic on the Osteogenic Differentiation of a Population of Multipotent Adult Human Stem Cells

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