2018
DOI: 10.1002/jcp.26608
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Retracted: Downregulated expression of microRNA‐329 inhibits apoptosis of nigral dopaminergic neurons by regulating CDKN2D expression via the FoxO3a signaling pathway in rats with Parkinson's disease

Abstract: Parkinson's disease (PD) is a common neurodegenerative disorder due to the loss of dopaminergic neurons in the substantia nigra. This study focuses on the effect of microRNA-329 (miR-329) on nigral dopaminergic neurons in a rat model of PD via the FoxO3a signaling pathway by binding to CDKN2D. Brain tissues from the substantia nigra were taken from the rats in two groups. TUNEL staining was used to observe tyrosine hydroxylase (TH)-positive neurons. Nigral dopaminergic neurons were randomized into the normal, … Show more

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Cited by 6 publications
(1 citation statement)
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“…Thus, while FoxO3 can protect cells from α-synuclein toxicity, it may also be responsible for neuronal death. In a rat model of PD, FoxO3 was found to inhibit the apoptosis in nigral dopaminergic neurons in a CDKN2D-dependent manner [ 188 ]. Likewise, the dFOXO function varies in different PD models in Drosophila .…”
Section: Role Of Foxo In Age-associated Diseasesmentioning
confidence: 99%
“…Thus, while FoxO3 can protect cells from α-synuclein toxicity, it may also be responsible for neuronal death. In a rat model of PD, FoxO3 was found to inhibit the apoptosis in nigral dopaminergic neurons in a CDKN2D-dependent manner [ 188 ]. Likewise, the dFOXO function varies in different PD models in Drosophila .…”
Section: Role Of Foxo In Age-associated Diseasesmentioning
confidence: 99%