Retracted: Knockdown of long noncoding RNA urothelial carcinoma–associated 1 inhibits cell viability, migration, and invasion by regulating microRNA‐182 in gastric carcinoma

Qin, Lei; Jia, Zhihua; Xie, Dawei; Liu, Zhong-Yuan

doi:10.1002/jcb.27344

Cited by 17 publications

(15 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The PI3K/AKT pathway has been reported to be activated in multiple types of tumor malignancies 25. Moreover, the PI3K/AKT pathway was associated with migration and invasion in many cancers, such as prostate cancer, lung cancer, and gastric cancer 26–28. We hypothesized that the PI3K/AKT pathway might be involved in migration and invasion in our effort.…”

Section: Discussionmentioning

confidence: 97%

Licochalcone A inhibits cell proliferation, migration, and invasion through regulating the PI3K/AKT signaling pathway in oral squamous cell carcinoma

Hao¹,

Zhang²,

Sun³

et al. 2019

OTT

View full text Add to dashboard Cite

Background: Oral squamous cell carcinoma (OSCC) is one of the most common cancers, with high metastasis and mortality. Licochalcone A (LCA) is a chalconoid from the root of Glycyrrhiza inflata , which has anti-tumor, anti-inflammatory, anti-angiogenesis effects in many cancers. However, the mechanism that underlies LCA regulating cell proliferation, migration, and invasion in OSCC remains poorly understood. Methods: LY294002 or insulin-like growth factor 1 (IGF-1) were used to block or stimulate the phosphatidylinositol 3 kinase (PI3K)/protein kinase B (AKT) pathway in OSCC cells. Cell proliferation was investigated by MTT assay and proliferating cell nuclear antigen (PCNA) protein level using Western blot. The expression of metastasis-related protein was detected via Western blot. Cell migration and invasion abilities were evaluated by trans-well assay. A murine xenograft model of OSCC was established to investigate the anti-tumor effect of LCA in vivo. Results: Treatment of LCA inhibited cell proliferation in SCC4 and CAL-27 cells. Moreover, PI3K/AKT signaling was blocked by LY294002, and activated by IGF-1. LCA could suppress proliferation, migration, and invasion of OSCC cells, which was similar to the treatment of LY294002. In addition, LCA decreased IGF-1-induced OSCC progression. In a murine xenograft model, LCA treatment protected against tumor growth and metastasis in vivo. Conclusions: LCA might inhibit cell proliferation, migration, and invasion through regulating the PI3K/AKT pathway in OSCC, developing a potential chemotherapeutic agent for OSCC.

show abstract

Section: Discussionmentioning

confidence: 97%

Licochalcone A inhibits cell proliferation, migration, and invasion through regulating the PI3K/AKT signaling pathway in oral squamous cell carcinoma

Hao¹,

Zhang²,

Sun³

et al. 2019

OTT

View full text Add to dashboard Cite

show abstract

“…Gastric cancer (GC) is a malignant tumor and has the highest morbidity and mortality in Asian countries; UCA1 is positively associated with GC proliferation and invasion [62]. UCA1 could significantly promote cell migration and inhibit apoptosis in GC cell lines SUN-216 and SGC-7091 via inhibition of miR-182, whose downstream target is tissue inhibitors of metalloproteinase 2 (TIMP2) [63]. Similarly, UCA1 enhanced the invasion of GC by directly interacting with miR-203 or miR-7-5p, increasing the release of miR-203-targeted transcripts zinc finger E-box-binding homeobox2 (ZEB2) or miR-7-5p-targeted epidermal growth factor receptor (EGFR), respectively [64,65].…”

Section: Gastrointestinal Cancersmentioning

confidence: 99%

Crosstalk between the lncRNA UCA1 and microRNAs in cancer

Xuan

Zhang

et al. 2019

FEBS Letters

View full text Add to dashboard Cite

Long non-coding RNAs (lncRNAs) are a major subset of highly conserved non-coding RNAs (ncRNAs) that consist of at least 200 nucleotides and have limited protein-coding potential. Cumulative data have shown that lncRNAs are deregulated in many types of cancer and may control pathophysiological processes of cancer at various levels, including transcription, post-transcription and translation. Recently, lncRNAs have been demonstrated to interact with microRNAs (miRNAs), another major subset of ncRNAs, which regulate physiological and pathological processes by inhibiting target mRNA translation or promoting mRNA degradation. The lncRNA urothelial carcinomaassociated 1 (UCA1) has recently gained much attention as it is overexpressed in many types of cancer and is involved in carcinogenesis. Here, we review the crosstalk between UCA1 and miRNAs during the pathogenesis of cancer, with a focus on cancer-cell proliferation, invasion, drug resistance, and metabolism.

show abstract

“…10,11 Furthermore, previous studies demonstrate that miR-182 displays the suppressive role in gastric cancer development. [12][13][14] Rho-associated protein kinase 1 (ROCK1) is an important oncogene in human cancers, including gastric cancer. [15][16][17][18][19] To explore the association among circNRIP1, miR-182 and ROCK1, we used starBase online to predict the putative seed sites of miR-182 and circNRIP1 or ROCK1.…”

Section: Introductionmentioning

confidence: 99%

Down-Regulation of circNRIP1 Promotes the Apoptosis and Inhibits the Migration and Invasion of Gastric Cancer Cells by miR-182/ROCK1 Axis

Liang

2020

OTT

View full text Add to dashboard Cite

Aim: Circular RNAs (circRNAs) play important roles in the progression of human cancers. circRNA nuclear receptor interacting protein 1 (circNRIP1) has been reported to play as an oncogene in gastric cancer. However, the mechanism underlying circNRIP1 in gastric cancer progression is far from understood. Patients and Methods: Forty-five gastric cancer patients were recruited and overall survival of patients was analyzed. Gastric cancer cell lines MGC-803 and AGS cells were cultured for study in vitro. The expression levels of circNRIP1, microRNA (miR)-182 and rho-associated protein kinase 1 (ROCK1) were detected by quantitative real-time polymerase chain reaction or Western blot. Cell migration, invasion, cell cycle distribution and apoptosis were determined by transwell, flow cytometry and Western blot assays, respectively. The target association between miR-182 and circNRIP1 or ROCK1 was assessed by luciferase reporter assay and RNA immunoprecipitation. Results: circNRIP1 expression was enhanced in gastric cancer tissues and cells and high expression of circNRIP1 indicated poor survival of patients. Knockdown of circNRIP1 suppressed cell migration and invasion, arrested cell cycle at G0-G1 phase and promoted apoptosis in gastric cancer cells. miR-182 was a target of circNRIP1 and its deficiency reversed the effect of circNRIP1 silence on cell migration, invasion, cell cycle distribution and apoptosis in gastric cancer cells. Moreover, ROCK1 was validated as a target of miR-182 and competitively regulated by circNRIP1. Conclusion: Silence of circNRIP1 inhibited progression of gastric cancer by increasing miR-182 and decreasing ROCK1, providing a novel target for the treatment of gastric cancer.

show abstract

Retracted: Knockdown of long noncoding RNA urothelial carcinoma–associated 1 inhibits cell viability, migration, and invasion by regulating microRNA‐182 in gastric carcinoma

Abstract: Knockdown of UCA1 exerts an anticancer effect on GC cells by regulating miR-182.

Cited by 17 publications

References 33 publications

<p>Licochalcone A inhibits cell proliferation, migration, and invasion through regulating the PI3K/AKT signaling pathway in oral squamous cell carcinoma</p>

<p>Licochalcone A inhibits cell proliferation, migration, and invasion through regulating the PI3K/AKT signaling pathway in oral squamous cell carcinoma</p>

Crosstalk between the lncRNA UCA1 and microRNAs in cancer

<p>Down-Regulation of circNRIP1 Promotes the Apoptosis and Inhibits the Migration and Invasion of Gastric Cancer Cells by miR-182/ROCK1 Axis</p>

Contact Info

Product

Resources

About