Retracted: Knockdown of SRPX2 inhibits the proliferation, migration, and invasion of prostate cancer cells through the PI3K/Akt/mTOR signaling pathway

Abstract

Sushi repeat‐containing protein X‐linked 2 (SRPX2), a novel chondroitin sulfate proteoglycan, is reported to play a critical role in tumorigenesis. However, the expression and functional role of SRPX2 in prostate cancer have not been defined. Thus, the aim of this study was to investigate the expression and functional role of SRPX2 in human prostate cancer. Our results showed that the expression of SRPX2 was obviously increased in human prostate cancer tissues and cell lines. In addition, knockdown of SRPX2 inhibited the proliferation, migration, and invasion of prostate cancer cells, as well as prevented the epithelial‐mesenchymal transition process in prostate cancer cells. Mechanically, knockdown of SRPX2 efficiently inhibited the activation of PI3K/Akt/mTOR pathway in prostate cancer cells. Taken together, these data demonstrated that knockdown of SRPX2 inhibits the proliferation and metastasis in human prostate cancer cells, partly through the PI3K/Akt/mTOR signaling pathway. Thus, SRPX2 may be a novel therapeutic target for the treatment of prostate cancer.

Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape

“…Moreover, LIF has been shown to help mediate astrocyte differentiation ( Nakashima et al, 1999 ). The pathogenic role and impact of SRPX2 in GBM ( Tang et al, 2016 ) is less well characterised, despite been well studied in cancer ( Hong et al, 2018 ; Tanaka et al, 2009 ; Lin et al, 2017 ; Zhang et al, 2018 ). Analysis of the pattern of expression of SRPX2 in our dataset found that it was up-regulated in the comparisons between iNSC and iAPC across all patients, and its expression was specifically higher in the GICs of patients 19 and 31 ( Figure 4E ), as expected.…”

SPLICE-q: a Python tool for genome-wide quantification of splicing efficiency

“…Previous studies showed SRPX2 to play an important role in cancer development and progression. In colorectal cancer, the overexpression of SRPX2 may promote invasiveness of tumor cells [33], and in prostate cancer, a knockdown of SRPX2 affected the proliferation, migration and invasion of cancer cells by partially suppressing the PI3K/Akt/mTOR signaling pathway [34]. PI3K/Akt/mTOR regulates cell proliferation and survival in different cancer types and is usually activated in advanced prostate cancer [35, 36].…”

Global hypo-methylation in a subgroup of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape

“…Moreover, it has been shown to help mediate astrocyte differentiation 72 . The pathogenic role and impact of SRPX2 in GBM 73 is less well characterised, despite been well studied in cancer [74][75][76][77] . Analysis of the pattern of expression of SRPX2 in our data set found that it was up-regulated in the comparisons between iNSC and iAPC across all patients, and its expression was specifically higher in the GICs of patients 19, 31 and 44 (Figure 4 E), as expected.…”