Retracted: LINC00707 contributes to hepatocellular carcinoma progression via sponging miR‐206 to increase CDK14

Abstract

Recently, increasing numbers of long noncoding RNAs (lncRNAs) have been found to be aberrantly expressed in various cancers. However, the roles of lncRNAs in hepatocellular carcinoma (HCC) progression is largely unknown. In our current study, we identified that long intergenic nonprotein‐coding RNA 707 (LINC00707) was remarkably elevated in HCC cells, indicating that LINC00707 was involved in HCC development. Subsequently, LINC00707 was significantly decreased in HepG2 and Huh7 cells. The in vitro functional assays demonstrated that knockdown of LINC00707 significantly reduced HCC cell proliferation, induced cell apoptosis, and blocked the cell cycle progression. In addition, HCC cell migration and invasion was also greatly inhibited by downregulation of LINC00707. Increasing evidence has indicated that lncRNAs can act as molecular sponges of microRNAs. Currently, we observed that microRNA‐206 (miR‐206) was dramatically inhibited in HCC cells and LINC00707 can modulate HCC development through sponging miR‐206. The binding correlation between LINC00707 and miR‐206 was confirmed by dual‐luciferase reporter assay, RNA pull down and RNA immunoprecipitation assay in our study. Moreover, cyclin‐dependent kinase 14 (CDK14) was predicted as a target of miR‐206 and we found that miR‐206 suppressed CDK14 levels in HCC cells. Finally, in vivo assays were used and it was proved that silence of LINC00707 can restrain HCC development through modulating miR‐206 to upregulate CDK14. In conclusion, it was implied that LINC00707 can lead to HCC progression through sponging miR‐206 and modulating CDK14.

Data Mining and Expression Analysis of Differential lncRNA ADAMTS9-AS1 in Prostate Cancer

“…Recently, many studies have supported a novel regulatory mechanism of lncRNA in human cancers, mainly represented by the interaction between lncRNA and miRNA. LncRNA can act as a ceRNA or molecular sponge to regulate miRNA expression and regulate the occurrence and progression of many cancers (Tu et al, 2019;Ao et al, 2019;Yu et al, 2019). For example, lncRNA Unigene 56159 promotes the epithelial-mesenchymal transition of hepatoma cells by acting as a ceRNA of miR-140-5p (Lv et al, 2016).…”

Long non‑coding RNA LINC00707 acts as a competing endogenous RNA to enhance cell proliferation in colorectal cancer

“…The subcellular localization of LINC00707 was also examined in the present study, and the cytoplasmic location of LINC00707 indicated the potential ceRNA role of LINC00707 in CRC. To date, LINC00707 has been confirmed to bind miR-206, miR-370-3p, miR-876 and miR-30a-5p (12,(24)(25)(26). As all lncRNAs, LINC00707 can bind multiple miRNAs, as long as they share a miRNA response element.…”

“…The majority of cytoplasmic lncRNAs serve key roles in the development of human cancers by acting as ceRNAs of miRNAs (22,23). LINC00707 has been demonstrated to induce hepatocellular carcinoma progression through sponging miR-206 and modulating the expression of CDK14 (12). LINC00707 was recently reported to promote osteogenesis by sponging miR-370-3p (24).…”

“…Long intergenic non-protein coding RNA 70 (LINC00707) is located on chromosome 10p14 and has a length of 3,097 bp. LINC00707 has been confirmed to be upregulated in lung adenocarcinoma and hepatocellular carcinoma and act as an oncogene to promote cancer development and progression (10)(11)(12). LINC00707 has been demonstrated to promote the proliferation and metastasis of gastric cancer (GC) by interacting with human antigen R (HuR) (13), which indicates that this molecule may also serve an important role in digestive tract tumors.…”

Silencing long intergenic non‑coding RNA 00707 enhances cisplatin sensitivity in cisplatin‑resistant non‑small‑cell lung cancer cells by sponging miR‑145

“…For example, Jia et al (21) reported that LINC00707 sponged miR-370-3p to promote the osteogenesis of human bone marrow-derived mesenchymal stem cells by increasing WNT2B. In addition, Tu et al (22) found that LINC00707 contributed to hepatocellular carcinoma progression by sponging miR-206, which led to the upregulation of CDK14. In the present study, miR-145 was identified as a target of LINC00707.…”