<i>Retracted</i>: Long non‐coding RNA SNHG14 contributes to gastric cancer development through targeting miR‐145/SOX9 axis

Liu, Zhao; Yan, Yan; Cao, Sizhe; Chen, Yi

doi:10.1002/jcb.26889

Cited by 67 publications

(61 citation statements)

References 35 publications

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“…Sox9 transcriptionally activates LASP-1 expression to increase cell proliferation, migration, and invasion in lung cancer [ 22 ]. Recent studies demonstrated that lncRNAs act as competitive endogenous RNA (ceRNA) to post-transcriptionally regulate Sox9 expression, such as SNHG14 and MALAT1 [ 23 , 24 ]. However, to date, whether lncRNAs are involved in the post-translational modification of Sox9 protein remains unclear.…”

Section: Discussionmentioning

confidence: 99%

A negative feedback loop between long noncoding RNA NBAT1 and Sox9 inhibits the malignant progression of gastric cancer cells

Yan¹,

Huang²,

Huang³

et al. 2018

Bioscience Reports

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Long noncoding RNAs (lncRNAs) play critical roles in carcinogenesis and progression, and act as important gene expression modulators. Recent evidence indicates that lncRNA neuroblastoma associated transcript 1 (NBAT1) functions as a tumor suppressor in some types of human cancers. However, its functional role in the development of gastric cancer (GC) remains unknown. The aim of this research was to investigate the clinical significance and biological functions of NBAT1 in GC. NBAT1 was found to be significantly down-regulated in GC tissue. Decreased NBAT1 expression was correlated with poor differentiation, higher tumor stage and lymph node metastasis, and poor prognosis. Functional assays showed that NBAT1 inhibited GC proliferation, migration, and invasion. NBAT1 also suppressed proliferation, migration, and capillary tube formation of human umbilical vein endothelial cells (HUVECs). Mechanistically, NBAT1 interacted with Sox9, and reduced its protein stability by promoting it from polyubiquitination and proteasome-dependent degradation. Moreover, we revealed that Sox9 could occupy the NBAT1 promoter to inactivate its transcription. The negative feedback loop of NBAT1 and Sox9 continuously enhanced the suppressive effects. In conclusion, these findings suggest that feedback regulation of NBAT1 and Sox9 served as a critical effector in GC progression.

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Section: Discussionmentioning

confidence: 99%

A negative feedback loop between long noncoding RNA NBAT1 and Sox9 inhibits the malignant progression of gastric cancer cells

Yan¹,

Huang²,

Huang³

et al. 2018

Bioscience Reports

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“…miR-511 inhibits the activation of the PI3K/Akt signaling pathway in breast cancer cells by targeting SOX9. SOX9 participates in the regulation of the PI3K/Akt signaling pathway (30,31); thus, whether miR-511 inactivates PI3K/Akt signaling in breast cancer cells was examined. To test this hypothesis, western blot analysis was performed to detect the molecules associated with the PI3K/Akt pathway in MCF-7 and MDA-MB-231 cells following co-transfection with miR-511 mimics and pcDNA3.1 or pcDNA3.1-SOX9.…”

Section: Sox9 Expression Is Negatively Correlated With Mir-511 Expresmentioning

confidence: 99%

MicroRNA-511 inhibits malignant behaviors of breast cancer by directly targeting SOX9 and regulating the PI3K/Akt pathway

et al. 2018

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Numerous studies have revealed that a subset of microRNAs (miRNAs) is aberrantly expressed in breast cancer. The dysregulation of miRNAs is involved in the tumorigenesis and progression of breast cancer due to their negative regulation of downstream target genes. Therefore, the identification of deregulated miRNAs in breast cancer may provide important insights into the diagnosis and treatment of patients with this disease. miRNA-511 (miR-511) has been identified to be deregulated in diverse human cancer types; however, neither the expression status nor the detailed roles of miR-511 in breast cancer have been clarified. Thus, it was aimed to determine the expression of miR-511 in breast cancer, examine the role in malignant progression and explore its downstream targets. The results of the present study revealed that the expression of miR-511 was downregulated in breast cancer tissues and cell lines. Decreased expression of miR-511 was significantly associated with lymph node metastasis and tumor stage in patients with breast cancer. Functional analyses revealed that restoring miR-511 expression suppressed breast cancer cell proliferation and colony formation, promoted apoptosis and reduced metastasis in vitro, while it attenuated tumor growth in vivo. Additionally, it was revealed that SRY-box 9 (SOX9) was a direct target gene of miR-511 in breast cancer cells. SOX9 was upregulated in breast cancer tissues and its expression was inversely correlated with that of miR-511. Furthermore, SOX9 inhibition simulated the tumor-suppressive roles of miR-511 overexpression in breast cancer cells, while SOX9 reintroduction partially rescued these effects of miR-511. Notably, the upregulation of miR-511 targeted SOX9 to deactivate the PI3K/Akt signaling in breast cancer in vitro and in vivo. In conclusion, miR-511 was downregulated in breast cancer, and impeded its malignant progression by directly targeting SOX9 and regulating the PI3K/Akt pathway. Thus, miR-511 is a potential therapeutic target in breast cancer.

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“…GAS5 has been proved to regulate cardiac fibroblast activation and fibrosis [11]. In addition, SNHG14 was reported to contribute to cell proliferation of gastric cancer cells through miR-145/SOX9 axis [12]. Recently, long intergenic non-protein coding RNA 511 (LINC00511) was widely reported in multiple tumors.…”

Section: Introductionmentioning

confidence: 99%

LINC00511 exacerbated T-cell acute lymphoblastic leukemia via miR-195-5p/LRRK1 axis

Guo

Geng³

et al. 2020

Bioscience Reports

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T-cell acute lymphoblastic leukemia (T-ALL) is a malignant disease arising from the abnormal proliferation of T lymphocyte in marrow. Long non-coding RNAs (lncRNAs) are one kind of non-coding RNAs (ncRNAs), which were reported to modulate the initiation or progression of diverse cancers. However, the role of LINC00511 in T-ALL was unknown. To figure out the function and mechanism of LINC00511 in T-ALL, a series of experiments were carried out. Based on the experimental results, we discovered that LINC00511 boosted cell proliferation and invasion, but hindered cell apoptosis in T-ALL cells. Besides, based on bio-informatics tool, miR-195-5p was selected for further exploration. Then, miR-195-5p was validated to bind with LINC00511. Hereafter, LRRK1 was testified to serve as a target gene of miR-195-5p. At last, rescue assays suggested that LRRK1 overexpression restored sh-LINC00511#1-mediated effects on cell proliferation and apoptosis. All in all, LINC00511 exacerbated T-ALL progression via miR-195-5p/LRRK1 axis, implying a potential therapeutic clue for the patients with T-ALL.

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Retracted: Long non‐coding RNA SNHG14 contributes to gastric cancer development through targeting miR‐145/SOX9 axis

Cited by 67 publications

References 35 publications

A negative feedback loop between long noncoding RNA NBAT1 and Sox9 inhibits the malignant progression of gastric cancer cells

A negative feedback loop between long noncoding RNA NBAT1 and Sox9 inhibits the malignant progression of gastric cancer cells

MicroRNA-511 inhibits malignant behaviors of breast cancer by directly targeting SOX9 and regulating the PI3K/Akt pathway

LINC00511 exacerbated T-cell acute lymphoblastic leukemia via miR-195-5p/LRRK1 axis

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