<i>Retracted:</i> Metformin versus laparoscopic ovarian drilling in clomiphene‐ and insulin‐resistant women with polycystic ovary syndrome

Hamed, Hossam O.; Hasan, Asmaa F.; Ahmed, Omyma Galal; Ahmed, Marwa A.

doi:10.1016/j.ijgo.2009.08.033

Cited by 40 publications

(51 citation statements)

References 26 publications

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“…Androgen excess in PCOS is believed to be the result of insulin's ability to increase androgen production by ovarian theca cells (22,23). The significant decline in postdrilling serum androgens and LH that is seen more obviously in patients who received an adjusted thermal dose could be explained by adequate thermal destruction of androgen-secreting stroma cells.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: Laparoscopic ovarian drilling in polycystic ovary syndrome: efficacy of adjusted thermal dose based on ovarian volume

Zakherah¹,

Kamal²,

Hamed³

2011

Fertility and Sterility

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Section: Discussionmentioning

confidence: 99%

RETRACTED: Laparoscopic ovarian drilling in polycystic ovary syndrome: efficacy of adjusted thermal dose based on ovarian volume

Zakherah¹,

Kamal²,

Hamed³

2011

Fertility and Sterility

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“…The major pharmacological action of metformin is reduction of glucose production by the liver and improvement of IR. It is widely used for treatment of PCOS‐related infertility symptoms, especially in those with CC resistance . Our metformin data agrees with previous studies, which showed significant decrease in WC, IR and T levels .…”

Section: Discussionsupporting

confidence: 92%

“…All women met the criteria for diagnosis of PCOS according to Rotterdam Consensus Group . CC resistance is defined as failure to ovulate with CC for at least 3 months at a dose of 150 mg/day for 5 days . The exclusion criteria included women under 20 or over 38 years and patients who had received gonadotrophins or hormonal contraception in the 3 months prior to the study.…”

Section: Methodsmentioning

confidence: 99%

Role of adiponectin and its receptor in prediction of reproductive outcome of metformin treatment in patients with polycystic ovarian syndrome

Hamed

2013

J of Obstet and Gynaecol

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Aims: The aim of this study was to examine the effect of metformin on serum adiponectin and adiponectin receptor-1 (AdipoR1) and evaluate their role in prediction of ovulation in patients with polycystic ovarian syndrome (PCOS). Material and Methods:The study cohort included 68 PCOS patients with clomiphene citrate resistance (group 1) and 28 healthy women as controls (group 2). Baseline serum adiponectin, AdipoR1, total testosterone (T), and homeostasis model of insulin resistance (HOMA-IR) were measured in all participants. Group 1 received metformin (1500 mg/day) for 6 months followed by second blood sampling. Results: Group 1 had significantly lower baseline adiponectin and AdipoR1 (P = 0.001) compared to group 2. During treatment, metformin resulted in conception in 5/68 (7%), ovulation in 33/68 (48%) and regular cycles in 41/68 (60%) patients. Group 1 showed post-metformin higher adiponectin and AdipoR1 (P = 0.01) and lower HOMA-IR (P = 0.006) and T (P = 0.001) compared to pre-treatment levels. Post-metformin ovulatory patients had higher adiponectin and AdipoR1 and lower HOMA-IR and T compared to anovulatory patients. Multivariate regression analysis in group 1 showed that only T and HOMA-IR were significant independent factors for predicting ovulatory cycles during metformin treatment (P = 0.04 and P = 0.05, respectively). Conclusions: Metformin treatment enhances both adiponectin activity and insulin sensitivity, resulting in a less hyperandrogenic state in patients with PCOS. Serum adiponectin and AdipoR1 are poor predictors of ovulatory outcome during treatment.

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“…It had no significantly higher chance at pregnancy or higher pregnancy rates in women with PCOS [6]. In patients with clomiphene resistance where it is being advocated, LOD was found to reduce testosterone and Luteinising hormone levels and associated with more regular cycles, higher ovulation and pregnancy rates compared to metformin alone even though metformin results in more attenuation of luteinizing hormone [28]. Emerging evidence shows that unilateral ovarian drilling has similar effects as bilateral ovarian drilling in bringing about ovulation, pregnancy rates, and life birth rates.…”

Section: Surgery and Ovulation Induction 41 Use Of Ovarian Drillingmentioning

confidence: 98%

Ovulation Induction in Women with Polycystic Ovary Syndrome: What is the Optimal Option?

Oriji¹,

Nyengidiki²

2018

Debatable Topics in PCOS Patients

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Infertility is a distressing medical and psychosocial problem afflicting about a quarter of all couples wanting to reproduce their offspring. Majority of the anovulatory problem in the female, as a cause of infertility, is due to polycystic ovary syndrome (PCOS). This condition is a complex interplay of factors, which affect women even beyond their fertility. It has been found to increase the risk of other adverse condit i o n ss u c ha st h em e t a b o l i cs y n d r o m e ,c a r diovascular diseases, type II diabetes mellitus, and endometrial cancer as well as infertility. Different groups have made diagnosis of PCOS with various diagnostic criteria. The Rotterdam criteria used in the diagnosis of PCOS mainly emphasize the reproductive malfunctions of this complex disease. The treatment of anovulatory infertility in PCOS is as enigmatic as the disease itself. Various methods have been deployed to treat the anovulation with variable success. Clomiphene citrate is a traditional first-line drug in treating anovulation in women with PCOS. Weight reduction, letrozole, metformin, folliclestimulating hormone (FSH) and ovarian drilling are some of the other ways in which anovulation has been treated in these women. What method is more likely to succeed in treating the infertility from anovulation in PCOS and in what circumstance are the subject matters of this discussion.

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Retracted: Metformin versus laparoscopic ovarian drilling in clomiphene‐ and insulin‐resistant women with polycystic ovary syndrome

Abstract: Although metformin results in a better attenuation of insulin resistance, laparoscopic ovarian drilling is associated with higher rates of ovulation and pregnancy.

Cited by 40 publications

References 26 publications

RETRACTED: Laparoscopic ovarian drilling in polycystic ovary syndrome: efficacy of adjusted thermal dose based on ovarian volume

RETRACTED: Laparoscopic ovarian drilling in polycystic ovary syndrome: efficacy of adjusted thermal dose based on ovarian volume

Role of adiponectin and its receptor in prediction of reproductive outcome of metformin treatment in patients with polycystic ovarian syndrome

Ovulation Induction in Women with Polycystic Ovary Syndrome: What is the Optimal Option?

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