<i>Retracted:</i> MicroRNA‐575 targets BLID to promote growth and invasion of non‐small cell lung cancer cells

Wang, Hongwei; Yan, Chunhua; Shi, Xiaodong; Zheng, Jian; Deng, Lili; Yang, Lei; Yu, Fangfei; Yang, Yuandi; Shao, Yanping

doi:10.1016/j.febslet.2015.02.013

Cited by 39 publications

(29 citation statements)

References 27 publications

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“…Although the remaining two miRNAs are not reported to have direct relationships with CRC or to affect radiotherapy, they play crucial roles in other cancers. For example, miR-575 contributes to non-small cell lung cancer cell growth and invasion [18], whereas miR-513 combines with 12 other miRNAs as a 13-miRNA signature that participates in regulating tumorigenesis [19]. …”

Section: Resultsmentioning

confidence: 99%

Identification of biomarker microRNAs for predicting the response of colorectal cancer to neoadjuvant chemoradiotherapy based on microRNA regulatory network

et al. 2016

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Preoperative radiotherapy or chemoradiotherapy has become a standard procedure for treatment of patients with locally advanced colorectal cancer (CRC). However, patients’ responses to treatment are different and personalized. MicroRNAs (miRNAs) are promising biomarkers for predicting personalized responses. In this study, we collected 30 publicly reported miRNAs associated with chemoradiotherapy of CRC. We extracted 46 differentially expressed miRNAs from samples of responders and non-responders to preoperative radiotherapy from the Gene Expression Omnibus dataset (Student's t test, p-value < 0.05 and |fold-change| > 2). We performed a systematic and integrative bioinformatics analysis to identify biomarker miRNAs for prediction of CRC responses to chemoradiotherapy. Using the bioinformatics model, miR-198, miR-765, miR-671-5p, miR-630, miR-371-5p, miR-575, miR-202, miR-483-5p and miR-513a-5p were screened as putative biomarkers for treatment response. Literature validation and functional enrichment analysis were exploited to confirm the reliability of the predicted miRNAs. Quantitative polymerase chain reaction showed that seven of the candidates were significantly differentially expressed between radiosensitive and insensitive CRC cell lines. The unique target genes of miR-198 and miR-765 were altered significantly upon transfection of specific miRNA mimics in the radiosensitive cell line. These results demonstrated the predictive power of our model and suggested that miR-198, miR-765, miR-630, miR-371-5p, miR-575, miR-202 and miR-513a-5p could be used for predicting the response of CRC to preoperative chemoradiotherapy.

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Section: Resultsmentioning

confidence: 99%

Identification of biomarker microRNAs for predicting the response of colorectal cancer to neoadjuvant chemoradiotherapy based on microRNA regulatory network

et al. 2016

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“…MiR-575 was located on human chromosome 4q21.22, and functioned as an oncogene in cancer, such as non-small cell lung cancer and gastric cancer [23, 24]. To further explore the potential function of miR-575 in HCC, we determined overexpression and restoration of miR-575 on HCC cell proliferation, migration and invasion.…”

Section: Discussionmentioning

confidence: 99%

“…It is identified that MIR31HG harbors miR-575 binding sites by bioinformatics analysis. In addition, miR-575 was found to exhibit a high expression in non-small cell lung cancer and gastric cancer tissues [23, 24]. However, the expression and biological function of miR-575 in HCC still remain unknown, and the miRNA sponge role of MIR31HG in HCC has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA MIR31HG inhibits hepatocellular carcinoma proliferation and metastasis by sponging microRNA-575 to modulate ST7L expression

Yan

Tang

Chen

et al. 2018

J Exp Clin Cancer Res

100

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BackgroundEmerging evidences have indicated that long noncoding RNAs (lncRNAs) play essential roles in the development and progression of cancers. Dysregulation of lncRNA MIR31HG has recently been reported in several types of cancers, and researches on the function of MIR31HG in cancers suggested that MIR31HG could act as either oncogene or tumor suppressor. But the functional involvement of MIR31HG has not been studied in hepatocellular carcinoma (HCC).MethodsIn this study, MTS assays, colony formation assay, Wound-healing assay, Transwell assy, and tumor xenografts experiments were used to identify biological effects of MIR31HG on HCC cells HCC proliferation and metastasis in vitro and in vivo. Dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay were performed to show the interactions of MIR31HG and miR-575. The bioinformatics methods were completed to find the target genes of miR-575. And Dual-luciferase reporter assay and Western blot analysis were further used to confirm the target gene of miR-575.ResultsWe found that overexpression of MIR31HG obviously suppressed HCC proliferation and metastasis in vitro and in vivo, whereas knockdown of MIR31HG had the opposite effects. Besides, overexpression of MIR31HG significantly decreased the expression of microRNA-575 (miR-575), which plays an oncogenic role in HCC. Moreover, dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay revealed that MIR31HG exerted tumor-suppressive functions by binding directly to miR-575, and there was a reciprocal inhibition between MIR31HG and miR-575 in the same RNA-induced silencing complex (RISC). Furthermore, overexpression of MIR31HG enhanced the expression of suppression of tumorigenicity 7 like (ST7L), which was identified as a downstream target gene of miR-575. Thus, MIR31HG positively regulated ST7L expression through sponging miR-575, and acted as tumor suppressor in HCC.ConclusionsOverall, our study illuminates the role of MIR31HG as a miRNA sponge in HCC, and sheds new light on lncRNA-directed diagnostics and therapeutics in HCC.Electronic supplementary materialThe online version of this article (10.1186/s13046-018-0853-9) contains supplementary material, which is available to authorized users.

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“…The miRNA hsa-miR-575 regulates all mRNAs in the module and mRNA EGFR has interactions with the other five mRNAs. Wang et al [21] demonstrated that hsa-miR-575 is a onco-miRNA. Yang et al [22] described that hsa-miR-3142 regulate cell growth and viability of thyroid cancer cells in part by repressing expression of USF2, RCL1 and SACS.…”

Section: Discussionmentioning

confidence: 99%

Detecting Composite Functional Module in miRNA Regulation and mRNA Interaction Network

Yang

Chu

2017

Algorithms

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Abstract:The detection of composite miRNA functional module (CMFM) is of tremendous significance and helps in understanding the organization, regulation and execution of cell processes in cancer, but how to identify functional CMFMs is still a computational challenge. In this paper we propose a novel module detection method called MBCFM (detecting Composite Function Modules based on Maximal Biclique enumeration), specifically designed to bicluster miRNAs and target messenger RNAs (mRNAs) on the basis of multiple biological interaction information and topical network features. In this method, we employ algorithm MICA to enumerate all maximal bicliques and further extract R-pairs from the miRNA-mRNA regulatory network. Compared with two existing methods, Mirsynergy and SNMNMF on ovarian cancer dataset, the proposed method of MBCFM is not only able to extract cohesiveness-preserved CMFMs but also has high efficiency in running time. More importantly, MBCFM can be applied to detect other cancer-associated miRNA functional modules.

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Retracted: MicroRNA‐575 targets BLID to promote growth and invasion of non‐small cell lung cancer cells

Cited by 39 publications

References 27 publications

Identification of biomarker microRNAs for predicting the response of colorectal cancer to neoadjuvant chemoradiotherapy based on microRNA regulatory network

Identification of biomarker microRNAs for predicting the response of colorectal cancer to neoadjuvant chemoradiotherapy based on microRNA regulatory network

Long noncoding RNA MIR31HG inhibits hepatocellular carcinoma proliferation and metastasis by sponging microRNA-575 to modulate ST7L expression

Detecting Composite Functional Module in miRNA Regulation and mRNA Interaction Network

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