<i>Retracted</i>: MiR‐892a Promotes Hepatocellular Carcinoma Cells Proliferation and Invasion Through Targeting CD226

Jia, Bin; Tan, Ludong; Jin, Zhe; Jiao, Yan; Fu, Yu; Liu, Yahui

doi:10.1002/jcb.25808

Cited by 19 publications

(8 citation statements)

References 23 publications

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“…In recent years, some researches began to pay attention to the expression of CD226 in tumor cells. These studies found that expression of CD226 on hepatoma cells was down-regulated and that expression was related to the survival rate and survival time of patients (Baoxing et al, 2017). In addition, CD226 gene polymorphism was found to be directly related to tumor risk (Shaoqing et al, 2013).…”

Section: Cd226 and Tumorsmentioning

confidence: 97%

CD226: An Emerging Role in Immunologic Diseases

Huang

Miller

et al. 2020

Front. Cell Dev. Biol.

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CD226, a member of the immunoglobulin superfamily, is a functional protein initially expressed on natural killer and T cells. In recent years, the function of CD226 has been increasingly realized and researched. Accumulating evidence shows that CD226 is closely related to the occurrence of autoimmune diseases, infectious diseases, and tumors. Because of the CD226's increasing importance, the author herein discusses the structure, mechanism of action, and role of CD226 in various pathophysiological environments, allowing for further understanding of the function of CD226 and providing the basis for further research in related diseases.

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Section: Cd226 and Tumorsmentioning

confidence: 97%

CD226: An Emerging Role in Immunologic Diseases

Huang

Miller

et al. 2020

Front. Cell Dev. Biol.

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“…Our laboratory has also been committed to the study of cancer biomarkers for patient prognosis. [18][19][20][21] In this study, we found that HK1 participates in the glycolysis of OC cells and may be an independent biomarker for the poor prognosis of OC patients. Glucose metabolism enzymes are associated with cancer prognosis.…”

Section: Discussionmentioning

confidence: 55%

<p>Prognostic Significance and Related Mechanisms of Hexokinase 1 in Ovarian Cancer</p>

Li¹,

Tian²,

Luo³

et al. 2020

OTT

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Purpose Ovarian cancer (OC) has the highest mortality among gynecological malignancies. Therefore, it is urgent to explore prognostic biomarkers to improve the survival of OC patients. One of the most prominent metabolic characteristics of cancer is effective glycolysis. Hexokinase 1 (HK1), as the first rate-limiting enzyme in glycolysis, is closely related to cancer progression. However, the role of HK1 in OC remains unclear. Materials and Methods The Cancer Genome Atlas (TCGA) database was used to detect the expression of HK1 in OC patients. The chi-squared test was performed to examine the correlations between HK1 and patients’ clinical characteristics. Survival analyses were undertaken to determine the relationship between HK1 and patient survival, while the univariate/multivariate Cox model was used to evaluate the role of HK1 in patient prognosis. Gene Set Enrichment Analysis (GSEA) was performed to ascertain the related signaling pathways of HK1. RT-qPCR was implemented to validate the mRNA expression of HK1 in OC cells. MTT was used to detect cell viability after adding 2DG and knocking down HK1 in OC cells. HK1 protein expression was examined by Western blotting. Glucose uptake, lactate production, and ATP assays were undertaken following knockdown of HK1 in OC cells. Colony formation assays were performed to determine OC cell proliferation after HK1 knockdown. Transwell and wound healing assays were carried out to detect the invasion and migration of OC cells after HK1 knockdown. Results We found that HK1 expression was increased in OC tissues and cells, and HK1 was related to the clinical characteristics of OC patients. Survival analysis revealed that OC patients in the HK1 overexpression group had poor survival. Moreover, univariant/multivariate analyses showed that HK1 may be an independent biomarker for the poor prognosis of OC patients. OC cell viability and proliferation decreased after knockdown of HK1 . Consistently, glucose uptake, lactic acid production, ATP production, invasion, and migration were also decreased. Finally, GSEA enrichment analysis and Western blotting showed that HK1 was involved in MAPK/ERK signaling. Conclusion HK1 may be a biomarker for the poor prognosis of OC patients and a potential therapeutic target.

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“…While in HCC-favorable gene set, many genes have been identified to be associated with HCC, such as VIPR1, CPEB3, HTR2A-AS1, ACSM3, ADRA1A, AKR1D1, BHMT, CD226, CD5L, CYP3A4, CYP3A43, DMGDH, ESR1, GLYATL1 and RDH16. Low expression of VIPR1 had an adverse prognostic impact on HCC [20], loss of ACSM3 expression was found to correlate with advanced HCC stages and a poor survival [21], down-regulation of BHMT in HCC associates with poor prognosis [22], low-expressed of CD226 could promote proliferative, migrating, and invasive activities of HCC cells [23], down-regulation of CYP3A4 gene is an independent predictor of early recurrence of HCC [24]. The results of the previous study were consistent with our findings.…”

Section: Discussionmentioning

confidence: 99%

Identification and validation of a ten-gene set variation score as a diagnostic and prognostic stratification tools in hepatocellular carcinoma

Zhao

Lin

et al. 2020

Preprint

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We aimed to identify the progress of hepatocellular carcinoma (HCC)-specific gene set. Using the HCC data set from The Cancer Genome Atlas, we found that 10 genes were gradually up-graduated with the progress of HCC and associated with survival and classed as HCC-unfavorable gene set, while 29 genes were gradually down-graduated and associated with survival and classed as HCC-favorable gene set. Gene Set Variation Analysis (GSVA) was used to score individual samples against the two gene sets. ROC curve analysis showed both of HCC-unfavorable GSVA score and HCC-favorable GSVA score were reliable biomarkers for diagnosing HCC, tROC curve analysis and univariate/multivariate Cox proportional hazards analyses indicated that HCC-unfavorable GSVA score was an independently prognostic biomarkers. Moreover, the results were validated in an external independent data set. In addition, according to mutation and methylation analysis, we proposed that the aberrant expression of HCC-unfavorable gene may be driven by hypomethylation, not mutation.

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Retracted: MiR‐892a Promotes Hepatocellular Carcinoma Cells Proliferation and Invasion Through Targeting CD226

Cited by 19 publications

References 23 publications

CD226: An Emerging Role in Immunologic Diseases

CD226: An Emerging Role in Immunologic Diseases

<p>Prognostic Significance and Related Mechanisms of Hexokinase 1 in Ovarian Cancer</p>

Identification and validation of a ten-gene set variation score as a diagnostic and prognostic stratification tools in hepatocellular carcinoma

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