<i>Retracted:</i> MircoRNA‐1275 promotes proliferation, invasion and migration of glioma cells via SERPINE1

Wu, Dongmei; Wang, Shan; Wen, Xin; Han, Xin‐Rui; Wang, Yongjian; Fan, Shao‐Hua; Zhang, Zi-Feng; Shan, Qun; Lü, Jun; Zheng, Yuxin

doi:10.1111/jcmm.13760

Cited by 25 publications

(20 citation statements)

References 35 publications

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“…Previous study indicated that an increase of SERPINE1 expression protects against programmed cell death ( 45 ). Conversely, studies revealed that SERPINE1 deficiency promotes apoptosis in multiple cancer types, which is consistent with our observation ( 45 – 47 ). The underlying mechanism for SERPINE1 -mediated cell survival may involve activation of the Akt and ERK signaling pathways and suppression of Fas/FasL-dependent apoptosis ( 48 ).…”

Section: Discussionsupporting

confidence: 93%

Knockdown of SERPINE1 reverses resistance of triple‑negative breast cancer to paclitaxel via suppression of VEGFA

Zhang

Jiang

2020

Oncol Rep

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Breast cancer (BC) has a poor prognosis and a high number of visceral metastases. Serine protease inhibitor, clade E member 1 (SERPINE1) is a molecule involved in several human malignancies. However, it remains unknown if SERPINE1 plays a role in the development of taxane resistance in TNBC cells. In the present study, the role and mechanism of SERPINE1 in the development of paclitaxel (PTX) resistance in TNBC cells were investigated. A bioinformatics analysis of gene expression profiles in PTX-resistant cells indicated that SERPINE1 was significantly associated with PTX resistance. Furthermore, the levels of SERPINE1 mRNA and protein were higher in PTX-resistant cells with respect to those in PTX-sensitive parent cells. Knockdown of SERPINE1 significantly inhibited cell survival and induced cell apoptosis in vitro. In addition, SERPINE1 silencing led to downregulation of the key angiogenetic vascular endothelial growth factor A (VEGFA). Furthermore, suppression of SERPINE1 markedly attenuated tumor growth in vivo. Collectively, these findings indicated that SERPINE1 significantly contributed to the proliferation and apoptosis of TNBC cells by regulating VEGFA expression. The present study demonstrated SERPINE1 as an oncogene in PTX drug resistance of breast cancer, and revealed that it may serve as a possible target for treating BC.

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Section: Discussionsupporting

confidence: 93%

Knockdown of SERPINE1 reverses resistance of triple‑negative breast cancer to paclitaxel via suppression of VEGFA

Zhang

Jiang

2020

Oncol Rep

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“…For instance, down-regulation in the expression of AGER is associated with modulation of cell apoptosis, localization of NF-κB, phosphorylation of ERK1/2, and astrocyte reactivity leading toward neurodegeneration (Wang et al, 2002; Ohtaki et al, 2007; Choi et al, 2014; Kim et al, 2015; Gu et al, 2016). Differential expression of other molecules like MMP-2 (Matrix Matalloproteinase-2) and SERPINES 1/2 (Serpin family E member 1 and 2) results in the proteolytic cleavage of pericellular proteins and breakdown of extra-cellular matrix, stalls cell migration and neurite remodeling in the brain, which in turn can impact brain development (Ogier et al, 2006; Hagemann et al, 2012; Kamat et al, 2014; Wu et al, 2018; Yang et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Zika Virus Infection Disrupts Astrocytic Proteins Involved in Synapse Control and Axon Guidance

2019

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The first human Zika virus (ZIKV) outbreak was reported in Micronesia in 2007, followed by one in Brazil in 2015. Recent studies have reported cases in Europe, Oceania and Latin America. In 2016, ZIKV transmission was also reported in the US and the World Health Organization declared it a Public Health Emergency of International Concern. Because various neurological conditions are associated with ZIKV, such as microcephaly, Guillain-Barré syndrome, and other disorders of both the central and peripheral nervous systems, including encephalopathy, (meningo)encephalitis and myelitis, and because of the lack of reliable patient diagnosis, numerous ongoing studies seek to understand molecular mechanisms underlying ZIKV pathogenesis. Astrocytes are one of the most abundant cells in the CNS. They control axonal guidance, synaptic signaling, neurotransmitter trafficking and maintenance of neurons, and are targeted by ZIKV. In this study, we used a newly developed multiplexed aptamer-based technique (SOMAScan) to examine > 1300 human astrocyte cell proteins. We identified almost 300 astrocyte proteins significantly dysregulated by ZIKV infection that span diverse functions and signaling pathways, including protein translation, synaptic control, cell migration and differentiation.

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“…14 , 15 The microarray results showed that 30 miRNAs were differentially expressed, some of which were involved in the formation and metastasis of glioma. 16 …”

Section: Introductionmentioning

confidence: 99%

<p>miR-302e Suppresses Glioma Progression by Targeting VEGFA</p>

Xie¹,

Liu²,

Hu³

et al. 2020

CMAR

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Background MiRNA can be involved in regulating tumor genesis and development by regulating the expression of specific genes and regulating corresponding signaling pathways. In this study, we explored the function and mechanisms of miR-302e in glioma progression. Methods Experimental methods include the following: real-time quantitative PCR, Western Blot Analysis, CCK8 assay and detection of apoptosis. Results MiR-302e was down-regulated in cancer tissues and cell lines, and the expression of miR-302e was negatively correlated with the tumor grade, which indicated poor prognosis in glioma patients. Followed functional analysis showed overexpression of miR-302e inhibited proliferation, migration and invasion but promoted apoptosis of glioma cells, while silencing miR-302e showed the opposite effects. Mechanistic studies have shown that VEGFA was a directed target of miR-302e. Forced expression of VEGFA removed the inhibiting impact of miR-302e on glioma development. In vivo tumorigenesis experiments showed that miR-302e suppressed glioma development by targeting VEGFA. Conclusion Present study emphasized miR-302e suppressed glioma development by targeting VEGFA, which might be a valuable target for glioma treatment.

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Retracted: MircoRNA‐1275 promotes proliferation, invasion and migration of glioma cells via SERPINE1

Cited by 25 publications

References 35 publications

Knockdown of SERPINE1 reverses resistance of triple‑negative breast cancer to paclitaxel via suppression of VEGFA

Knockdown of SERPINE1 reverses resistance of triple‑negative breast cancer to paclitaxel via suppression of VEGFA

Zika Virus Infection Disrupts Astrocytic Proteins Involved in Synapse Control and Axon Guidance

<p>miR-302e Suppresses Glioma Progression by Targeting VEGFA</p>

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