<i>Retracted: </i>New bone formation in bone defects after melatonin and porcine bone grafts: experimental study in rabbits

Calvo-Guirado, José Luís; Gómez‐Moreno, Gerardo; Maté‐Sánchez, José‐Eduardo; López-Marí, Laura; Delgado-Ruíz, Rafael Arcesio; Romanos, Georgios E.

doi:10.1111/clr.12364

Cited by 27 publications

(25 citation statements)

References 43 publications

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“…The use of melatonin to promote bone regeneration in dental implant placement was assessed in several studies, based on different animal models in which the authors employed melatonin alone or in combination with other substances, such as, growth hormone or porcine bone [2,40,41,42,43,44,45,46,47]. The studies using melatonin to promote dental implant stability evaluated in this review are summarised in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Melatonin: A Review of Its Potential Functions and Effects on Dental Diseases

Permuy

López-Peña

González‐Cantalapiedra

et al. 2017

IJMS

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Melatonin is a hormone synthesised and secreted by the pineal gland and other organs. Its secretion, controlled by an endogenous circadian cycle, has been proven to exert immunological, anti-oxidant, and anti-inflammatory effects that can be beneficial in the treatment of certain dental diseases. This article is aimed at carrying out a review of the literature published about the use of melatonin in the dental field and summarising its potential effects. In this review article, an extensive search in different databases of scientific journals was performed with the objective of summarising all of the information published on melatonin use in dental diseases, focussing on periodontal diseases and dental implantology. Melatonin released in a natural way into the saliva, or added as an external treatment, may have important implications for dental disorders, such as periodontal disease, as well as in the osseointegration of dental implants, due to its anti-inflammatory and osseoconductive effects. Melatonin has demonstrated to have beneficial effects on dental pathologies, although further research is needed to understand the exact mechanisms of this molecule.

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Section: Resultsmentioning

confidence: 99%

Melatonin: A Review of Its Potential Functions and Effects on Dental Diseases

Permuy

López-Peña

González‐Cantalapiedra

et al. 2017

IJMS

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“…At the same time, significant osteoid matrix synthesis and mineralization accelerated early cell differentiation. It was observed to increase (Calvo-Guirado et al, 2015).…”

Section: Resultsmentioning

confidence: 91%

Effects of Melatonin on Tibia Bone Defects in Rats

et al. 2016

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KOPARAL, M.; IRTEGÜN, S.; ALAN, H.; DEVECI, E.; GÜLSÜN, B. & PEKTANÇ, G.Effects of melatonin on tibia bone defects in rats. Int. J. Morphol., 34(2):763-769, 2016. SUMMARY:The aim of this study was to evaluate the effects of melatonin healing in a tibial bone defect model in rats by means of histopathological and immunohistochemistry analysis. Twenty one male Wistar albino rats were used in this study. In each animal, bone defects (6 mm length ) were created in the tibias. The animals were divided into three groups. In group 1 control group (rats which tibial defects). Group 2 melatonin (10 mg/kg) + 14 days in the tibial defect group) was administered intraperitoneally to rats. Group 3 melatonin (10 mg/kg) + 28 days in the tibial defect group) was administered intraperitoneally to rats. Histopathological analysis of samples was performed to evaluate the process of osteoblastic activity, matrix formation, trabecular bone formation and myeloid tissue in bone defects. Immunohistochemical and immunoblot analysis demonstrated non-collagenous proteins (osteopontin and osteonectin) differences in tibial bone defects. The expression of osteopontin on tibia was increased by 14 days melatonin treatment. The expression of osteonectin on tibia was dramatically increased by 14 days melatonin treatment.

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“…Besides, MLT was given to CD-1 mice but not to Sprague-Dawley rats in the study of Histing et al [28]. Moreover, It is uncertain that whether MLT regulates NPY and NPY1R expression via MLT receptors because MLT can work by both receptor-dependent and -independent mechanisms [29,30]. Previous studies showed that the level of NPY was increased by MLT treatment [31,32].…”

Section: Discussionmentioning

confidence: 99%

Melatonin Induces Osteoblastic Differentiation of Mesenchymal Stem Cells and Promotes Fracture Healing in a Rat Model of Femoral Fracture via Neuropeptide Y/Neuropeptide Y Receptor Y1 Signaling

Dong

Zhu

et al. 2018

Pharmacology

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The function of melatonin (MLT) in promoting fracture healing has been demonstrated in previous studies. However, the molecular mechanism underlying therapeutic effects of MLT is not entirely clear. In this study, mesenchymal stem cells (MSCs) were isolated from rat bone marrow and identified by flow cytometry. We found that MLT treatment upregulated the neuropeptide Y (NPY) and NPY receptor Y1 (NPY1R) expression, and promoted the proliferation and migration of MSCs, which was suppressed by BIBP3226, an inhibitor of NPY1R. Moreover, the levels of NPY and NPY1R in MSCs undergoing osteoblastic differentiation were upregulated after MLT administration. MLT-induced osteoblastic differentiation of MSCs was suppressed by BIBP3226 treatment, as evidenced by decreased levels of alkaline phosphatase (ALP), collagen type I α1 chain, osteocalcin, and runt-related transcription factor 2, downregulated activity of ALP, as well as reduced calcium nodule formation. Furthermore, we demonstrated that MLT could promote fracture healing in a rat model of femoral fracture, which was accompanied by the elevated expression of NPY and NPY1R. The administration of BIBP3226 inhibited fracture healing mediated by MLT. To sum up, our results show that MLT promotes osteoblastic differentiation of MSCs and fracture healing by NPY/NPY1R signaling.

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Retracted: New bone formation in bone defects after melatonin and porcine bone grafts: experimental study in rabbits

Abstract: Melatonin has proven to regenerate the width and length of cortical bone in tibiae rabbits more quickly than collagenized porcine bone. Melatonin acts as a bone stimulator compared with porcine bone and control sites.

Cited by 27 publications

References 43 publications

Melatonin: A Review of Its Potential Functions and Effects on Dental Diseases

Melatonin: A Review of Its Potential Functions and Effects on Dental Diseases

Effects of Melatonin on Tibia Bone Defects in Rats

Melatonin Induces Osteoblastic Differentiation of Mesenchymal Stem Cells and Promotes Fracture Healing in a Rat Model of Femoral Fracture via Neuropeptide Y/Neuropeptide Y Receptor Y1 Signaling

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