<i>Rhodotorula</i> species fungaemia causes low mortality in haematopoietic stem‐cell transplantation. A case report and review

Forés, Rafael; Ramos, Antonio; Orden, Beatriz; Laiglesia, Almudena de; Bautista, Guiomar; Cabero, Martin; Múñez, Elena; Sánchez-Romero, Isabel; Navarro, Belén; Bravo, Julio; Cabrera, Rafael

doi:10.1111/j.1439-0507.2011.02164.x

Cited by 13 publications

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“…Another important finding of our study is that most cases occurred as breakthrough infections, as 70% of our patients were receiving antifungal prophylaxis with azoles. Such a percentage is higher than those of previous cases reported in literature, ranging from 9% to 45% . In our study, the most frequently adopted azole was posaconazole, while fluconazole was the azole most commonly reported in the literature .…”

Section: Discussioncontrasting

confidence: 74%

“…So far the characterisation of infection by Rhodotorula derived from either overlapping reviews of the literature or smaller monocentric studies . Our study confirms that Rhodotorula infections in haematological patients is associated with the presence of CVC in the majority of cases.…”

Section: Discussionsupporting

confidence: 74%

“…Our study confirms that Rhodotorula infections in haematological patients is associated with the presence of CVC in the majority of cases. Previous publications reported the presence of a CVC in 84.6% (ranging from 62.5% to 100%) . Another important finding of our study is that most cases occurred as breakthrough infections, as 70% of our patients were receiving antifungal prophylaxis with azoles.…”

Section: Discussionsupporting

confidence: 54%

“…Indeed, our study reports one of the largest case series of Rhodotorula infections in alloSCT patients. At the best of our knowledge, only 15 cases of Rhodotorula infections have so far been described in patients undergoing SCT, of which only three undergoing alloSCT . Accordingly, the presence of mucositis, which is a frequent complication in patients with acute leukaemia and in alloSCT recipients, was associated with mortality in our survey.…”

Section: Discussionmentioning

confidence: 65%

“…The risk factors most frequently reported for developing Rhodotorula spp infection overlap with the ones of candidiasis and include neutropenia, administration of immunosuppressive drugs and the presence of cancer either solid or haematologic. Nevertheless, there is a paucity of data regarding invasive Rhodotorula infections in the most vulnerable population,that one of patients with haematological cancer and/or hematopoietic stem cell transplantation . To that end, we report on the largest collection of Rhodotorula cases in haematological patients from tertiary care centres and in order to describe risk factors and treatment outcome.…”

Section: Introductionmentioning

confidence: 99%

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Rhodotorula infection in haematological patient: Risk factors and outcome

Potenza

Chitasombat

Климко

et al. 2018

Mycoses

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Summary Background Rhodotorula spp are uncommon yeasts able to cause infections with high mortality rates. Rhodotorula infections have been associated with the presence of central venous catheter (CVC), immunosuppression, exposure to antifungals and the presence of either solid or haematologic malignancies. However, in this latter setting, only a few cases have so far been reported. Objectives We have conducted a survey for Rhodotorula infections in haematologic patients. Methods Patients’ clinical and microbiological data were collected and correlated to the outcome. Results A total of 27 cases were detected from 13 tertiary care hospitals. About 78% and 89% of patients had acute leukaemia and CVC. About 70% of patients were exposed to prophylaxis with azoles, mainly posaconazole (37%), 59% were severely neutropenic and 37% underwent allogeneic stem cell transplantation (alloSCT). The most frequent treatments were liposomal amphotericin B (L‐AmB) and CVC removal in 17 and 16 patients, respectively. One month post‐diagnosis, mortality was 26% and was associated with the presence of mucositis (P = 0.034). Conclusions Our study shows that Rhodotorula spp should be considered as aetiologic agents of breakthrough infections in acute leukaemia patients with a CVC, mucositis, who receive prophylaxis with azoles, including posaconazole, and/or undergo alloSCT. Prompt measures, such as L‐AmB administration and CVC removal, should be carried out to avoid the high mortality risk of Rhodotorula infections.

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Section: Discussioncontrasting

confidence: 74%

Section: Discussionsupporting

confidence: 74%

Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

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