<i>Rickettsia typhi</i>
            infection in severe fever with thrombocytopenia patients, China

Zhang, Shao‐Fei; Du, Juan; Mi, Xian-Miao; Lu, Qing‐Bin; Bai, Jing; Cui, Ning; Yang, Zhen‐Dong; Wang, Zhibo; Zhang, Xiao-Ai; Zhang, Pan-He; Li, Hao; Liu, Wei

doi:10.1080/22221751.2019.1599696

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease caused by the SFTS virus (SFTSV) and transmitted via bites of the tick Haemaphysalis longicornis. 1,2 Severe fever with thrombocytopenia syndrome virus belongs to the genus Bandavirus and family Phenuiviridae and was first isolated from the specimens of Chinese patients in 2009. 3 This virus is related to, but distinctly different from, the Heartland virus.…”

Section: Introductionmentioning

confidence: 99%

Clinical Progress and Risk Factors for Death from Severe Fever with Thrombocytopenia Syndrome: A Multihospital Retrospective Investigation in Anhui, China

Gong

Zhang²,

et al. 2021

The American Journal of Tropical Medicine and Hygiene

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Knowledge of the clinical progress of severe fever with thrombocytopenia syndrome (SFTS) and the associated predictors of mortality is important for providing appropriate treatment in severe cases. A multihospital retrospective study was conducted in three SFTS-endemic cities, in 2018. Of the 208 SFTS-confirmed cases, there were 189 survivors and 19 deaths. The median age was 64 years; 104 (50.0%) patients were men, and 188 (90.4%) were farmers. Furthermore, 203 (97.6%) patients reported fever and 70 (33.7%) reported fatigue. Most fatal cases had complications including multiple-organ failure, central nervous syndrome (CNS) abnormalities, and disseminated intravascular coagulation. During the fever phase, alanine transaminase, aspartate aminotransferase (AST), blood urea nitrogen (BUN), creatinine, D-dimer, glucose, hydroxybutyrate dehydrogenase, lactate dehydrogenase (LDH), procalcitonin, prothrombin time, and uric acid levels were higher in fatal than in nonfatal cases (P < 0.05). Creatine kinase (CK), CK-MB (CKMB), AST, and LDH levels were significantly lower in nonfatal than in fatal cases (P < 0.05). Central nervous syndrome abnormalities (odds ratio [OR] = 20.9, 95% CI: 4.3, 100), body temperature ≥ 38.5°C (OR = 23.2, 95% CI: 3.4, 158), BUN levels ≥ 6.4 mmol/L (OR = 9.9, 95% CI: 2.2, 44), CKMB levels ≥ 100 U/L (OR = 33.2, 95% CI: 5.8, 192), and LDH levels ≥ 1,000 U/L (OR = 8.3, 95% CI: 1.9, 37) were predictors of mortality. Our findings reveal that the presence of specific complications and laboratory parameters may serve as predictors of mortality and aid in early identification of severe SFTS cases in clinical practice.

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Section: Introductionmentioning

confidence: 99%

Clinical Progress and Risk Factors for Death from Severe Fever with Thrombocytopenia Syndrome: A Multihospital Retrospective Investigation in Anhui, China

Gong

Zhang²,

et al. 2021

The American Journal of Tropical Medicine and Hygiene

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“…According to the nomenclature by the International Committee on Taxonoy of Viruses (ICTV), SFTSV has been classified into the Genus Banyangvirus, Family Phenuivirdae and named as Huaiyangshan banyangvirus [ 1 ]. The disease is mainly transmitted through the bite of Haemaphysalis longicornis [ 2 ]. Human-to-human transmission also occurs through contact with the bodily fluid of an infected person [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical features of severe fever with thrombocytopenia syndrome and analysis of risk factors for mortality

Zheng

Zhang

2021

BMC Infect Dis

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Background To understand the clinical characteristics of and explore the risk factors for mortality in patients with severe fever with thrombocytopenia syndrome (SFTS). Methods Data from SFTS patients diagnosed by laboratory examination at Chaohu Hospital affiliated with Anhui Medical University from June 2017 to January 2021 were retrospectively analysed. According to the clinical results, all confirmed patients were divided into the surviving group (80 patients) and non-surviving group (20 patients). The two groups were compared in terms of general characteristics, clinical symptoms and signs, laboratory indicators and other aspects. The independent risk factors for mortality in SFTS patients were analysed by multivariate binary logistic regression. Results Univariate analysis showed a significant difference in age and the incidence of consciousness disturbance, respiratory failure, haemorrhagic manifestations, renal dysfunction, shock, aspartate aminotransferase (AST) ≥400 U/L, creatine kinase (CK)≥1000 U/L, creatine kinase isoenzymes (CK-MB) ≥100 U/L, lactate dehydrogenase (LDH) ≥1000 U/L, serum creatinine ≥100 mmol/L, blood urea nitrogen ≥7.5 mmol/L and C-reactive protein ≥8 mg/L between the two groups (P < 0.05). Conclusions Consciousness disorder, haemorrhagic manifestations, renal dysfunction, AST ≥ 400 U/L, and LDH ≥ 1000 U/L are independent risk factors for mortality in SFTS patients and merit close attention in clinical treatment to avoid fatal consequences.

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“…Recent cases have also been reported from South America, Mexico, Europe, the Middle East, Africa, Asia, and Australia, [ 12 – 24 ] and travel-acquired cases are not uncommon [ 25 – 27 ]. Murine typhus manifests with fever including severe fever with thrombocytopenia, headache, vomiting, myalgia, malaise, and rash and generally has a low mortality rate [ 6 , 12 – 23 ], but may result in meningoencephalitis, interstitial pneumonia, shock, and respiratory failure in severe cases [ 4 , 22 , 24 – 25 ].…”

Section: Introductionmentioning

confidence: 99%

Genetic typing of isolates of Rickettsia typhi

Kato¹,

Chung²,

Robinson³

et al. 2022

PLoS Negl Trop Dis

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Murine typhus, which is caused by Rickettsia typhi, has a wide range of clinical manifestations. It has a low mortality rate but may result in meningoencephalitis and interstitial pneumonia in severe cases. Comparisons of complete genome sequences of R. typhi isolates from North Carolina, USA (Wilmington), Myanmar (B9991PP), and Thailand (TH1527) identified only 26 single nucleotide polymorphism (SNP) and 7 insertion-deletion (INDEL) sites in these highly syntenic genomes. Assays were developed to further define the distribution of these variant sites among 15 additional isolates of R. typhi with different histories from Asia, the USA, and Africa. Mismatch amplification mutation assays (MAMA) were validated for 22 SNP sites, while the 7 INDEL sites were analyzed directly on agarose gels. Six SNP types, 9 INDEL types, 11 total types were identified among these 18 isolates. Replicate DNA samples as well as comparisons of isolates with different passage and source histories gave consistent genetic typing profiles. Comparison of the SNP and INDEL markers to R. typhi’s nearest neighbor Rickettsia prowazekii demonstrated that the majority of the SNPs represent intra-species variation that arose post divergence of these two species while several INDEL sites also exhibited intraspecies variability among the R. prowazekii genomes that have been completely sequenced. The assays for the presence of these SNP and INDEL sites, particularly the latter, comprise a low technology gel method for consistently distinguishing R. typhi and R. prowazekii as well as for differentiating genetic types of R. typhi.

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Rickettsia typhi infection in severe fever with thrombocytopenia patients, China

Cited by 5 publications

References 23 publications

Clinical Progress and Risk Factors for Death from Severe Fever with Thrombocytopenia Syndrome: A Multihospital Retrospective Investigation in Anhui, China

Clinical Progress and Risk Factors for Death from Severe Fever with Thrombocytopenia Syndrome: A Multihospital Retrospective Investigation in Anhui, China

Clinical features of severe fever with thrombocytopenia syndrome and analysis of risk factors for mortality

Genetic typing of isolates of Rickettsia typhi

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