<i>Robinsoniella peoriensis</i>: An emerging pathogen and rare cause of wound infection in children

Krueger, Carsten; Azad, Marisa Ann; Ramotar, Karam; Deslandes, Vincent; Jessamine, Peter

doi:10.3138/jammi-2021-0038

Cited by 4 publications

(5 citation statements)

References 10 publications

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“…The literature search of the PubMed and Scopus databases yielded 52 non-duplicate studies. After screening all potentially eligible studies and the snowball procedure, only 14 studies met the inclusion criteria and were considered for data extraction [ 11 , 12 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. Figure 1 shows the flow diagram of study inclusion.…”

Section: Resultsmentioning

confidence: 99%

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Robinsoniella peoriensis Infections in Humans—A Narrative Review

Ioannou,

Baliou,

Kofteridis

2024

Antibiotics

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Robinsoniella peoriensis is a Gram-positive, strictly anaerobic, spore-forming, rod-shaped bacterium belonging to the phylum Firmicutes and the family Lachnospiraceae. Until now, R. peoriensis is the only species of its genus. It was first isolated in 2003 during a study into the flora of lagoons and manure pits. Given the rarity of this microorganism and the sparse information in the literature about its way of transmission, the way to diagnose its infections and identify it in the microbiology laboratory, and its public health relevance, the present study aimed to identify all the published cases of Robinsoniella, describe the epidemiological, clinical, and microbiological characteristics, and provide information about its antimicrobial resistance, treatment, and outcomes. A narrative review was performed based on a Pubmed/Medline and Scopus databases search. In total, 14 studies provided data on 17 patients with infections by Robinsoniella. The median age of patients was 63 years and 47% were male. The most common types of infection were bone and joint infections, bacteremia, infective endocarditis, and peritonitis. The only isolated species was R. peoriensis, and antimicrobial resistance to clindamycin was 50%, but was 0% to the combination of piperacillin with tazobactam, aminopenicillin with a beta-lactamase inhibitor, and metronidazole which were the most commonly used antimicrobials for the treatment of these infections. The overall mortality depends on the type of infection and is notable only for bacteremia, while all other infections had an optimal outcome. Future studies should better assess these infections’ clinical and epidemiological characteristics and the mechanisms of the antimicrobial resistance of this microorganism from a mechanistic and genetic perspective.

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Section: Resultsmentioning

confidence: 99%

“…The first one is trauma with fractures, which necessitates orthopedic surgery. Indeed, six such patients were identified in the present review [ 12 , 21 , 22 , 24 , 25 ]. In most of these cases, trauma led to open fractures that could allow the inoculation of environmental pathogens in the patients’ bones or joints.…”

Section: Discussionmentioning

confidence: 99%

Robinsoniella peoriensis Infections in Humans—A Narrative Review

Ioannou,

Baliou,

Kofteridis

2024

Antibiotics

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“…29,30 R. peoriensis is a gram-positive, spore forming, anaerobic bacillus that was characterized in 2003 from a swine manure sample and is an emerging human pathogen. 31 It caused bacteremia in a patient with pancreatic cancer. Upon treatment with intravenous metronidazole the patient died of multiple organ failure within a month of being admitted to the hospital.…”

Section: Discussionmentioning

confidence: 99%

An investigation for phylogenetic characterization of human Pancreatic cancer microbiome by 16SrDNA Sequencing and Bioinformatics techniques

Hunter,

Dia,

Boykins

et al. 2024

Preprint

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Pancreatic cancer is a significant public health concern, with increasing incidence rates and limited treatment options. Recent studies have highlighted the role of the human microbiome, particularly the gut microbiota, in the development and progression of this disease. Microbial dysbiosis, characterized by alterations in the composition and function of the gut microbiota, has been implicated in pancreatic carcinogenesis through mechanisms involving chronic inflammation, immune dysregulation, and metabolic disturbances. Researchers have identified specific microbial signatures associated with pancreatic cancer, offering potential biomarkers for early detection and prognostication. By leveraging advanced sequencing and bioinformatics tools, scientists have delineated differences in the gut microbiota between pancreatic cancer patients and healthy individuals, providing insights into disease pathogenesis and potential diagnostic strategies. Moreover, the microbiome holds promise as a therapeutic target in pancreatic cancer treatment. Interventions aimed at modulating the microbiome, such as probiotics, prebiotics, and fecal microbiota transplantation, have demonstrated potential in enhancing the efficacy of existing cancer therapies, including chemotherapy and immunotherapy. These approaches can influence immune responses, alter tumor microenvironments, and sensitize tumors to treatment, offering new avenues for improving patient outcomes and overcoming therapeutic resistance. Overall, understanding the complex interplay between the microbiome and pancreatic cancer is crucial for advancing our knowledge of disease mechanisms and identifying innovative therapeutic strategies. Here we report phylogenetic analysis of the 16S microbial sequences of the pancreatic cancer mice microbiome and corresponding age matched healthy mice microbiome. We successfully identified differentially abundance of microbiota in the pancreatic cancer.

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“…[29,30] Robinsoniella peoriensis is a gram-positive, spore forming, anaerobic bacillus that was characterized in 2003 from a swine manure sample and is an emerging human pathogen. [31] It caused bacteremia in a patient with pancreatic cancer. Upon treatment with intravenous metronidazole the patient died of multiple organ failure within a month of being admitted to the hospital.…”

Section: Discussionmentioning

confidence: 99%

An investigation for phylogenetic characterization of human pancreatic cancer microbiome by 16S rDNA sequencing and bioinformatics techniques

Hunter,

Dia,

Boykins

et al. 2024

JST

View full text Add to dashboard Cite

Pancreatic cancer is a significant public health concern, with increasing incidence rates and limited treatment options. Recent studies have highlighted the role of the human microbiome, particularly the gut microbiota, in the development and progression of this disease. Microbial dysbiosis, characterized by alterations in the composition and function of the gut microbiota, has been implicated in pancreatic carcinogenesis through mechanisms involving chronic inflammation, immune dysregulation, and metabolic disturbances. Researchers have identified specific microbial signatures associated with pancreatic cancer, offering potential biomarkers for early detection and prognostication. By leveraging advanced sequencing and bioinformatics tools, scientists have delineated differences in the gut microbiota between pancreatic cancer patients and healthy individuals, providing insights into disease pathogenesis and potential diagnostic strategies. Moreover, the microbiome holds promise as a therapeutic target in pancreatic cancer treatment. Interventions aimed at modulating the microbiome, such as probiotics, prebiotics, and fecal microbiota transplantation, have demonstrated potential in enhancing the efficacy of existing cancer therapies, including chemotherapy and immunotherapy. These approaches can influence immune responses, alter tumor microenvironments, and sensitize tumors to treatment, offering new avenues for improving patient outcomes and overcoming therapeutic resistance. Overall, understanding the complex interplay between the microbiome and pancreatic cancer is crucial for advancing our knowledge of disease mechanisms and identifying innovative therapeutic strategies. Here we report phylogenetic analysis of the 16S rDNA microbial sequences of the pancreatic cancer mice microbiome and corresponding age matched healthy mice microbiome. We successfully identified differentially abundant microbiota in pancreatic cancer.

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Robinsoniella peoriensis: An emerging pathogen and rare cause of wound infection in children

Cited by 4 publications

References 10 publications

Robinsoniella peoriensis Infections in Humans—A Narrative Review

Robinsoniella peoriensis Infections in Humans—A Narrative Review

An investigation for phylogenetic characterization of human Pancreatic cancer microbiome by 16SrDNA Sequencing and Bioinformatics techniques

An investigation for phylogenetic characterization of human pancreatic cancer microbiome by 16S rDNA sequencing and bioinformatics techniques

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