<i>Rothia dentocariosa</i>induces TNF-alpha production in a TLR2-dependent manner

Kataoka, Hideo; Taniguchi, Makoto; Fukamachi, Hiromi; Arimoto, Takafumi; Morisaki, Hirobumi; Kuwata, Hirotaka

doi:10.1111/2049-632x.12115

Cited by 32 publications

(27 citation statements)

References 30 publications

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“…In addition, our findings demonstrate for the first time the inhibitory effect of hydroalcoholic pomegranate extracts on R. dentocariosa , isolated from dental plaque, a bacterium considered as one of the main etiological agents of several oral diseases, including tooth decay [ 5 , 48 , 49 ].…”

Section: Discussionmentioning

confidence: 96%

In VitroAntibacterial Activity of Pomegranate Juice and Peel Extracts on Cariogenic Bacteria

Ferrazzano

Scioscia

Sateriale

et al. 2017

BioMed Research International

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Aim To evaluate the antimicrobial activity of hydroalcoholic extracts of pomegranate (Punica granatum L.) peel and juice, against the microorganisms considered the main etiologic agents of dental caries. Methods The values of the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) were determined against Streptococcus mutans Clarke ATCC® 25175™ strain and Rothia dentocariosa clinical isolate. Results Peel extracts inhibit effectively the growth and survival of S. mutans ATCC 25175 strain and R. dentocariosa clinical isolate with MIC and MBC values of 10 μg/μl and 15 μg/μl, respectively. Furthermore, the pomegranate juice extract showed high inhibitory activity against S. mutans ATCC 25175 strain with a MIC value of 25 μg/μl and a MBC value of 40 μg/μl, whereas, against R. dentocariosa, it has displayed a moderate inhibitory activity, with MIC and MBC values of 20 μg/μl and 140 μg/μl, respectively. Conclusions In vitro microbiological tests demonstrate that the hydroalcoholic extracts of pomegranate juice and peel are able to contrast the main cariogenic bacteria involved in tooth decay. Although being preliminary data, our results suggest that pomegranate polyphenolic compounds could represent a good adjuvant for the prevention and treatment of dental caries.

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Section: Discussionmentioning

confidence: 96%

In VitroAntibacterial Activity of Pomegranate Juice and Peel Extracts on Cariogenic Bacteria

Ferrazzano

Scioscia

Sateriale

et al. 2017

BioMed Research International

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“…Earlier studies showed that inflammation, insulin resistance, and impaired glucose tolerance are positively associated with Blautia (14,25), Rothia (26), and Bilophila (27) and negatively associated with Bacteroides, Parabacteroides (28), and Acinetobacter (29). In our study, we found that Blautia, Rothia, and Bilophila were less abundant whereas Bacteroides, Parabacteroides (28), and Acinetobacter were more abundant in T1 than in T2 in normoglycemic women, which is consistent with the increase in insulin resistance seen as pregnancy progressed.…”

Section: Discussionmentioning

confidence: 99%

Gestational Diabetes Mellitus Is Associated with Reduced Dynamics of Gut Microbiota during the First Half of Pregnancy

Zheng

Huang

et al. 2020

mSystems

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Women with gestational diabetes mellitus (GDM) have different gut microbiota in late pregnancy compared to women without GDM. It remains unclear whether alterations of gut microbiota can be identified prior to the diagnosis of GDM. This study characterized dynamic changes of gut microbiota from the first trimester (T1) to the second trimester (T2) and evaluated their relationship with later development of GDM. Compared with the control group (n = 103), the GDM group (n = 31) exhibited distinct dynamics of gut microbiota, evidenced by taxonomic, functional, and structural shifts from T1 to T2. Linear discriminant analysis (LDA) revealed that there were 10 taxa in T1 and 7 in T2 that differed in relative abundance between the GDM and control groups, including a consistent decrease in the levels of Coprococcus and Streptococcus in the GDM group. While the normoglycemic women exhibited substantial variations of gut microbiota from T1 to T2, their GDM-developing counterparts exhibited clearly reduced inter-time point shifts, as corroborated by the results of Wilcoxon signed-rank test and balance tree analysis. Moreover, cooccurrence network analysis revealed that the interbacterial interactions in the GDM group were minimal compared with those in the control group. In conclusion, lower numbers of dynamic changes in gut microbiota in the first half of pregnancy are associated with the development of GDM. IMPORTANCE GDM is one of the most common metabolic disorders during pregnancy and is associated with adverse short-term and long-term maternal and fetal outcomes. The aim of this study was to examine the connection between dynamic variations in gut microbiota and development of GDM. Whereas shifts in gut microbiota composition and function have been previously reported to be associated with GDM, very little is known regarding the early microbial changes that occur before the diagnosis of GDM. This study demonstrated that the dynamics in gut microbiota during the first half of pregnancy differed significantly between GDM and normoglycemic women. Our findings suggested that gut microbiota may potentially serve as an early biomarker for GDM.

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“…dentocariosa [ 63 ], and was first isolated from carious dentin in humans. It is mostly found in the flora of the oral cavity, dental caries, and dental plaque from periodontal patients, but also in blood, respiratory secretions, abscesses, and wounds [ 53 , 62 , 64 ]. R .…”

Section: Discussionmentioning

confidence: 99%

Oral health status in historic population: Macroscopic and metagenomic evidence

et al. 2018

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Recent developments in High-Throughput DNA sequencing (HTS) technologies and ancient DNA (aDNA) research have opened access to the characterization of the microbial communities within past populations. Most studies have, however, relied on the analysis of dental calculus as one particular material type particularly prone to the molecular preservation of ancient microbial biofilms and potential of entire teeth for microbial characterization, both of healthy communities and pathogens in ancient individuals, remains overlooked. In this study, we used shotgun sequencing to characterize the bacterial composition from historical subjects showing macroscopic evidence of oral pathologies. We first carried out a macroscopic analysis aimed at identifying carious or periodontal diseases in subjects belonging to a French rural population of the 18th century AD. We next examined radiographically six subjects showing specific, characteristic dental pathologies and applied HTS shotgun sequencing to characterize the microbial communities present in and on the dental material. The presence of Streptococcus mutans and also Rothia dentocariosa, Actinomyces viscosus, Porphyromonas gingivalis, Tannerella forsythia, Pseudoramibacter alactolyticus, Olsenella uli and Parvimonas micra was confirmed through the presence of typical signatures of post-mortem DNA damage at an average depth-of-coverage ranging from 0.5 to 7X, with a minimum of 35% (from 35 to 93%) of the positions in the genome covered at least once. Each sampled tooth showed a specific bacterial signature associated with carious or periodontal pathologies. This work demonstrates that from a healthy independent tooth, without visible macroscopic pathology, we can identify a signature of specific pathogens and deduce the oral health status of an individual.

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Rothia dentocariosainduces TNF-alpha production in a TLR2-dependent manner

Cited by 32 publications

References 30 publications

In VitroAntibacterial Activity of Pomegranate Juice and Peel Extracts on Cariogenic Bacteria

In VitroAntibacterial Activity of Pomegranate Juice and Peel Extracts on Cariogenic Bacteria

Gestational Diabetes Mellitus Is Associated with Reduced Dynamics of Gut Microbiota during the First Half of Pregnancy

Oral health status in historic population: Macroscopic and metagenomic evidence

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