(S)-Methyl 2-[(3R,4R)-2-benzyl-3-(2-furyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamido]-3-(1H-indol-3-yl)propanoate

Abstract

The title compound, C33H29N3O5, was synthesized by the reaction of racemic trans-2-benzyl-3-(2-fur­yl)-1-oxo-1,2,3,4-tetra­hydro­isoquinoline-4-carboxylic acid, l-tryptophan methyl ester and diisopropylcarbodiimide in dry dichloro­methane. The furan ring is disordered over two positions in a 0.859 (14):0.141 (14) ratio. In the 1,2,3,4-tetra­hydro­iso­quin­oline ring system, the heterocyclic ring is not planar, with puckering parameters Q T = 0.448 (2) Å, θ = 64.9 (3) and ϕ = 268.3 (3)°. The crystal is extended into a three-dimensional supra­molecular architecture through inter­molecular N—H⋯O hydrogen bonds and C—H⋯π inter­actions. The absolute structure was assigned by reference to the chiral starting material.