<i>S</i>-<sup>11</sup>C-Methyl-L-Cysteine: A New Amino Acid PET Tracer for Cancer Imaging

Deng, Hongxin; Tang, Xiaolan; Wang, Hongliang; Tang, Ganghua; Wen, Fuhua; Shi, Xiulin; Chen, Yi; Wu, Kening; Quanfei, Meng

doi:10.2967/jnumed.110.081349

Cited by 27 publications

(38 citation statements)

References 23 publications

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“…5 The radiochemical purity was more than 99% and the enantiomeric purity was more than 90% by highperformance liquid chromatography analysis. The total synthesis time from 11 CO 2 was approximately 12 minutes.…”

Section: Radiopharmaceutical Preparationmentioning

confidence: 99%

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Human Biodistribution and Radiation Dosimetry of S-11C-Methyl-L-Cysteine Using Whole-Body PET

Yao¹,

Tang²,

Tang³

et al. 2015

Clinical Nuclear Medicine

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Section: Radiopharmaceutical Preparationmentioning

confidence: 99%

“…Preliminary studies demonstrated that 11 C-MCYS had high uptake in brain tumor and was superior to 18 F-FDG and 11 C-MET in the differential diagnosis of malignant tumor from inflammatory tissue. 5 However, to our knowledge, the internal radiation dosimetry data of 11 C-MCYS in humans has not been published.…”

mentioning

confidence: 98%

Human Biodistribution and Radiation Dosimetry of S-11C-Methyl-L-Cysteine Using Whole-Body PET

Yao¹,

Tang²,

Tang³

et al. 2015

Clinical Nuclear Medicine

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“…Normal Kunming mice (female, 4-6 weeks old, 20-25g) for biodistrubution studies of [ 18 F]FPGLN and BALB/c nude mice (4-6 weeks old, 18-22g) for tumor-bearing models were obtained from Laboratory Animal Center of Sun Yat-Sen University (Guangzhou, China). The SPC-A-1 and PC-3 tumor-bearing models were made using the previously described methods [11, 23]. Tumor cells (1-2×10 7 ) were injected subcutaneously on left shoulder flank and allowed to grow for 2 to 3 weeks.…”

Section: Methodsmentioning

confidence: 99%

Radiosynthesis and preliminary biological evaluation of N-(2-[18F]fluoropropionyl)-L-glutamine as a PET tracer for tumor imaging

Tang

Gao

et al. 2016

Oncotarget

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In this study, radiosynthesis and biological evaluation of a new [18F]labeled glutamine analogue, N-(2-[18F]fluoropropionyl)-L-glutamine ([18F]FPGLN) for tumor PET imaging are performed. [18F]FPGLN was synthesized via a two-step reaction sequence from 4-nitrophenyl-2-[18F]fluoropropionate ([18F]NFP) with a decay-corrected yield of 30 ± 5% (n=10) and a specific activity of 48 ± 10 GBq/μmol after 125 ± 5 min of radiosynthesis. The biodistribution of [18F]FPGLN was determined in normal Kunming mice and high uptake of [18F]FPGLN was observed within the kidneys and quickly excreted through the urinary bladder. In vitro cell experiments showed that [18F]FPGLN was primarily transported by Na+-dependent system XAG− and was not incorporated into proteins. [18F]FPGLN displayed better stability in vitro than that in vivo. PET/CT studies revealed that intense accumulation of [18F]FPGLN were shown in human SPC-A-1 lung adenocarcinoma and PC-3 prostate cancer xenografts. The results support that [18F]FPGLN seems to be a possible PET tracer for tumor imaging.

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“…Correspondingly, [ S ‐methyl‐ 11 C]methyl‐ l ‐cysteine was recently synthesized according to a solid‐phase 11 C‐methylation method, whereby the precursor l ‐cysteine was loaded onto a C18 column and subsequently reacted with [ 11 C]CH 3 I ( 4 , X = I) …”

Section: C‐labelled Amino Acidsmentioning

confidence: 99%

Methods for ¹¹C‐ and ¹⁸F‐labelling of amino acids and derivatives for positron emission tomography imaging

Neumaier

Coenen

2013

Labelled Comp Radiopharmac

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The different concepts realized for the synthesis of (11) C- and (18) F-labelled amino acids are summarized. Carbon-11 enables principally authentic radiolabelling of natural occurring amino acids by substituting one of the skeleton carbons by the radionuclide. Fluorine-18 is a foreign element for natural amino acids. Because of its advantageous nuclidic properties for positron emission tomography, however, it becomes increasingly important in molecular imaging, also with amino acid analogues. Especially in the last decade, considerable progress has been made with the radiosynthesis of (18) F-labelled amino acids that are now clinically approved, and thus assure their availability. In contrast, the synthetic possibilities with (11) C-labelled amino acids are more limited because of the short half-life of carbon-11 which also hampers their wide spread use.

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S-¹¹C-Methyl-L-Cysteine: A New Amino Acid PET Tracer for Cancer Imaging

Cited by 27 publications

References 23 publications

Human Biodistribution and Radiation Dosimetry of S-11C-Methyl-L-Cysteine Using Whole-Body PET

Human Biodistribution and Radiation Dosimetry of S-11C-Methyl-L-Cysteine Using Whole-Body PET

Radiosynthesis and preliminary biological evaluation of N-(2-[18F]fluoropropionyl)-L-glutamine as a PET tracer for tumor imaging

Methods for ¹¹C‐ and ¹⁸F‐labelling of amino acids and derivatives for positron emission tomography imaging

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S-11C-Methyl-L-Cysteine: A New Amino Acid PET Tracer for Cancer Imaging

Cited by 27 publications

References 23 publications

Human Biodistribution and Radiation Dosimetry of S-11C-Methyl-L-Cysteine Using Whole-Body PET

Human Biodistribution and Radiation Dosimetry of S-11C-Methyl-L-Cysteine Using Whole-Body PET

Radiosynthesis and preliminary biological evaluation of N-(2-[18F]fluoropropionyl)-L-glutamine as a PET tracer for tumor imaging

Methods for 11C‐ and 18F‐labelling of amino acids and derivatives for positron emission tomography imaging

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S-¹¹C-Methyl-L-Cysteine: A New Amino Acid PET Tracer for Cancer Imaging

Methods for ¹¹C‐ and ¹⁸F‐labelling of amino acids and derivatives for positron emission tomography imaging