<i>Salacia crassifolia</i>(Celastraceae): CHEMICAL CONSTITUENTS AND ANTIMICROBIAL ACTIVITY

Rodrigues, Vanessa Gregório; Duarte, Lucienir Pains; Silva, Roqueline R.; Silva, Grácia D. F.; Mercadante-Simões, Maria Olívia; Takahashi, Jacqueline A.; Matildes, Bibiane Lindsay Guimarães; Fonseca, Thaisa Helena Silva; Gomes, Maria Aparecida; Filho, Sidney Augusto Vieira

doi:10.5935/0100-4042.20150001

Cited by 10 publications

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“…Pristimerin ( 2 ) is a naturally occurring quinonemethide triterpenoid, restricted to plants of the Celastraceae [ 16 ]. Previously, it has shown cytotoxic [ 17 ], antimicrobial [ 4 ], anti-inflammatory [ 18 ], and antioxidant [ 9 ] activities. Earlier studies showed that pristimerin is found mainly in the roots of Celastraceae species, while its precursor friedelin, and other similarly cyclized intermediates, are found in the leaves [ 5 , 6 ].…”

Section: Resultsmentioning

confidence: 99%

“…Beyond its use against cancer, S. crassifolia is utilized in traditional medicine as an antimicrobial and anti-inflammatory agent [ 3 ]. Previous phytochemical investigations of the hexane extract of the leaves of S. crassifolia led to the isolation of friedelanes [ 4 ], commonly found in the leaves of Celastraceae species, and known as precursors of quinone methide triterpenoids found in the roots of these species [ 5 , 6 ]. Twenty-one extracts from S. crassifolia , Salacia elliptica (Mart.)…”

Section: Introductionmentioning

confidence: 99%

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Cytotoxic Triterpenes from Salacia crassifolia and Metabolite Profiling of Celastraceae Species

et al. 2018

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The new pentacyclic triterpene 11β-hydroxypristimerin (1), along with the known metabolites pristimerin (2), 6-oxopristimerol (3) and vitideasin (4), were isolated from a Salacia crassifolia root wood extract, following a bioassay-guided fractionation approach. Both the extract and the purified triterpenes displayed pronounced cytotoxic activity against human cancer cell lines. The NCI-60 cell line screen revealed that compound 2 was the most active, with a mean GI50 of 0.17 μM, while compound 1 had a mean GI50 of 8.7 μM. A COMPARE analysis of the screening results showed that pristimerin is likely to be the main compound responsible for the cytotoxic activity of the extract (mean GI50 of 0.3 μg·mL−1). A targeted search for pristimerin and related derivatives using LC-MS/MS revealed the presence of pristimerin (2) and 6-oxopristimerol (3) in all Celastraceae species examined and in all plant parts tested, while vitideasin (4) was only detected in the genus Salacia.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cytotoxic Triterpenes from Salacia crassifolia and Metabolite Profiling of Celastraceae Species

et al. 2018

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“…Species from the genus Salacia are rich in phenolic compounds such as quinonemethide triterpenes and flavonoids, which exhibit potent antioxidant activity, mainly due to their redox properties, absorption or free radicals scavenging that can attack biomolecules such as DNA (Tanabe et al, 2008;Vellosa et al, 2009). Also, in the species S. crassifolia, several phenolic compounds can be found (Lima et al, 1969;Rodrigues et al, 2015), however, further studies evaluating the antioxidant and antigenotoxic activities of these isolated compounds are needed.…”

Section: Resultsmentioning

confidence: 99%

Mutagenicity and antimutagenicity of Salacia crassifolia (mart. Ex. Schult.) G. Don. evaluated by Ames test

et al. 2017

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Salacia crassifolia (Mart. Ex. Schult.) G. Don. is a bush which belongs to Celastraceae family and occurs specially in Brazilian Cerrado. Its leaves, stem, seeds and fruits are popularly used for several medicinal purposes, such as antitumoral, antirheumatic, anti-inflammatory and antimicrobial. In this study, the mutagenic and antimutagenic activities of S. crassifolia stem bark fractions (hexane, ethyl acetate and hydroalcoholic) were evaluated by the Ames mutagenicity assay in Salmonella typhimurium TA98 and TA100 strains. By the obtained results, all S. crassifolia fractions did not significantly increase the number of prototrophic revertants for histidine (His + ) in both S. typhimurium strains tested (p > 0.05), suggesting absence of mutagenicity. Regarding antimutagenicity, the fractions ethyl acetate and hydroalcoholic significantly decreased the number of His + revertants colonies induced by positive control for strain TA98 (p < 0.05), demonstrating protection against mutagenicity induced by 4-nitroquinolile1-oxide, whereas the hexane fraction did not show antimutagenic effect in this strain. In the TA100 strain, all fractions of S. crassifolia protected DNA against the harmful action of sodium azide, and the hexane fraction exhibited the greatest protection in this work. Thus, it's possible conclude that the fractions of S. crassifolia tested in this study could be used in chemoprevention.Keywords: Salacia crassifolia, stem bark fractions, ames test, absence of mutagenicity, antimutagenicity. + induzidas pelo controle positive para a cepa TA98 (p < 0.05), demonstrando sua ação protetora contra a mutagenicidade induzida por 4-nitroquinolile1-oxide, enquanto a fração hexânica não demonstrou efeito antimutagênico nesta cepa. Na cepa TA100, todas as frações de S. crassifolia protegeram o DNA contra a ação lesiva de azida sódica, e a fração hexânica exibiu a maior proteção desse trabalho. Assim, concluímos que as frações de S. crassifolia testadas neste estudo poderiam ser utilizadas em quimioprevenção. Mutagenicitade e antimutagenicidade dePalavras-chave: Salacia crassifólia, frações da casca do caule, teste de ames, ausência de mutagenicidade, antimutagenicidade.

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“…It is estimated that this family comprises a total of 1350 species belonging to 96 different genera . Many Celastraceae species present pharmacological activities such as antitumor, anti‐inflammatory, antimicrobial, antioxidant, antiviral, analgesic, and acetylcholinesterase inhibitor …”

Section: Introductionmentioning

confidence: 99%

Chemodiversity of Essential Oils from Nine Species of Celastraceae

Camargo

Duarte

Vidal

et al. 2020

Chemistry & Biodiversity

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Extracts and compounds obtained from several species of Celastraceae family are reported as potential sources of drugs due to their diverse pharmacological properties. Nevertheless, essential oil composition from these species is still little known. This work aimed at the analysis of essential oils obtained from different Brazilian Celastraceae species. A total of seventeen oils were obtained using hydrodistillation process and analyzed by gas chromatography/mass spectrometry (GC/MS). Principal component analysis (PCA) allowed the identification of a chemical composition pattern among the analyzed essential oils. Some compounds were more frequent among Celastraceae species, such as cis‐ and trans‐linalool oxide (14/17 oil samples), nerylacetone (13/17), linalool (11/17), β‐ionone (10/17), α‐ionone (9/17), nerolidol (10/17), decanal (10/17), and dodecanoic acid (10/17). These results contribute to the chemophenetics of Celastraceae species.

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Salacia crassifolia(Celastraceae): CHEMICAL CONSTITUENTS AND ANTIMICROBIAL ACTIVITY

Cited by 10 publications

References 0 publications

Cytotoxic Triterpenes from Salacia crassifolia and Metabolite Profiling of Celastraceae Species

Cytotoxic Triterpenes from Salacia crassifolia and Metabolite Profiling of Celastraceae Species

Mutagenicity and antimutagenicity of Salacia crassifolia (mart. Ex. Schult.) G. Don. evaluated by Ames test

Chemodiversity of Essential Oils from Nine Species of Celastraceae

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