<i>Salmonella</i>Typhimurium and<i>Salmonella</i>Enteritidis Infections in Sporadic Diarrhea in Children: Source Tracing and Resistance to Third-Generation Cephalosporins and Ciprofloxacin

Wei, Zhongqiu; Xu, Xuebin; Yan, Mei; Chang, Hailing; Li, Yuefang; Kan, Biao; Zeng, Mei

doi:10.1089/fpd.2018.2557

Cited by 34 publications

(29 citation statements)

References 42 publications

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“…strains resistant to ciprofloxacin have been isolated in both animal products and humans (Cosby et al, 2015). The 41% rate of ciprofloxacinresistant strains determined in the present study is in agreement with previous studies, which also found high incidence rates of resistant Salmonella spp., of 25.0% in Ghana (Andoh et al, 2017) and of 35.1% in Shanghai (Wei et al, 2019). These results are a matter of concern, as the emergence of such strains may lead to failure of the treatment of severe bacterial infections in human medicine (Costa et al, 2013;Shang et al, 2018).…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial Resistance in Salmonella Serovars Isolated From an Egg-Producing Region in Brazil

Benevides

Rubio

Alves

et al. 2020

Braz. J. Poult. Sci.

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Fowl paratyphoid infections are caused by different Salmonella serovars that can affect a wide range of hosts. Due to its complex epidemiology, Salmonella serovar identification is crucial for the development and implementation of monitoring and control programs in poultry farms. Moreover, the characterization of the antimicrobial resistance profiles of Salmonella strains isolated from livestock is relevant to public health because they are a common causative agent of foodborne diseases. The objective of this study was to investigate the presence of Salmonella spp. and to identify the antimicrobial resistance profiles of strains isolated in the midwestern region of São Paulo state, which accounts for the highest production of table eggs in Brazil. For this purpose, 2008 fecal samples were collected on 151 commercial layer farms and submitted to microbiological analyses. Twenty-two serovars were isolated from 80 (52.9%) farms, among which S. Mbandaka and S. Braenderup were the most prevalent. All isolates expressed resistance to at least one of the 23 antimicrobials tested, and the highest resistance rates were determined against streptomycin (93.5%) and sulfonamide (84.6%). Moreover, multidrug resistance was observed in 41% of the isolates and the maximum drug resistance profile was against ten different antimicrobials. Therefore, the identification of Salmonella serovars in poultry production provides epidemiological knowledge to develop prevention and control measures in order to ensure poultry health and to prevent human infection by multiresistant strains.

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Section: Resultsmentioning

confidence: 99%

Antimicrobial Resistance in Salmonella Serovars Isolated From an Egg-Producing Region in Brazil

Benevides

Rubio

Alves

et al. 2020

Braz. J. Poult. Sci.

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“…The resistance to ciprofloxacin was mediated by multiple mechanisms [35], and the main mechanism of mutations in QRDRs were investigated in this study. A high frequency of mutations in the gyrA, gyrB, parC, and parE gene were found, indicating the need of long-term surveillance on QRDRs.…”

Section: Discussionmentioning

confidence: 99%

Prevalence, serotypes, and antimicrobial resistance of Salmonella isolates from patients with diarrhea in Shenzhen, China

Shen

Chen²,

Ou³

et al. 2020

Preprint

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Background : Salmonella is one of the main causative agents of diarrhea which results in substantial disease burden. To determine the prevalence, serotype distribution, and antimicrobial resistance profiles of clinical Salmonella isolates in Shenzhen, a 6-year surveillance study was conducted. Methods: Three sentinel hospitals were chosen and patients who visited the gastroenteritis clinics with acute diarrhea were enrolled. Salmonella isolates from the stool samples were subjected to serotyping, antimicrobial susceptibility testing to 24 antibiotics, and detection of resistance genes. Results: A total of 297 (5.7%) Salmonella strains were isolated from stool samples from 5,239 patients. Among the 42 serovars identified, serovar Typhimurium was the most common serotype which represented 39.7% of the isolates (118), followed by serovar Enteritidis (71, 23.9%), London (12, 4.0%), 4, 5, 12: i: - (11, 3.7%), and Senftenberg (8, 2.7%). A high frequency of resistance was found in ampicillin (70.6%), piperacillin (64.5%), tetracycline (63.5%), and streptomycin (54.3%). Resistance to ampicillin and tetracycline was observed in 95.3% of S. Typhimurium isolates; and nalidixic acid in 93.1% of S. Enteritidis isolates. Resistance to 5 or more antimicrobial agents was found in 78.8% of S. Typhimurium and 69.0% of S. Enteritidis isolates. Conclusions: Salmonella is an important cause of acute gastroenteritis and a broad range of serotypes are prevalent in Shenzhen, with Enteritidis and Typhimurium being the most common serovars. The high level of antibiotic resistance is of public health significance and ongoing monitoring combined with rational use of antibiotics are recommended.

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“…The annual prevalence of NTS during 2015-2018 was stable with S. typhimurium and S. enteritidis serovars remaining predominant. Our latest study suggested the transmission sources of S. typhimurium and S. enteritidis in Shanghainese children were diverse, which imposes difficulty to control and prevent NTS infections in Shanghai (27).…”

Section: Discussionmentioning

confidence: 99%

Etiology of acute diarrhea in children in Shanghai, 2015-2018

Chang

Guo

Wei

et al. 2019

Preprint

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Background Diarrhea is still a major cause of childhood morbidity and mortality worldwide. This hospital-based study aimed to monitor the consecutive epidemiological trend of etiology in children with acute diarrhea in Shanghai.Methods Outpatient children with diarrhea were prospectively enrolled within 7 days after onset of diarrheal symptoms during 2015-2018. Fresh stool samples were collected for testing enteropathogens. Enteric bacteria were identified and typed through culture and serotyping. Enteric viruses were identified through real-time PCR assay. hadResults Enteric pathogens were identified in 1572 (58.4%) of the 2692 enrolled children with acute diarrhea. Viruses were more frequently detected than bacteria (41.3% versus 25.0%), and co-infection with 2 or more pathogens was found in 13% of outpatients. Nontyphoidal Salmonella spp . (NTS) was the most common bacteria with 10.3% of isolate rate, followed by enteropathogenic Escherichia coli (EPEC) (6.5%), enteroaggregative Escherichia coli (EAEC) (6.2%), Campylobacter spp . (3.6%), enterotoxigenic Escherichia coli (ETEC) (1.1%), Shigella spp . (0.2%), and enterohemorrhagic Escherichia coli (EHEC) (0.1%). Rotavirus was the most common virus with 16.0% of detection rate, followed by norovirus (15.5%), adenovirus (7.2%), sapovirus (3.0%) and astrovirus (2.7%).Conclusions Infectious diarrhea remains the major cause of diarrhea in children in Shanghai. Rotavirus, norovirus and NTS were the major enteric pathogens responsible for diarrhea in Shanghainese children. Improving uptake of rotavirus vaccine and strengthening prevention of foodborne pathogens will be helpful to reduce the burden of diarrheal diseases in children in Shanghai.

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SalmonellaTyphimurium andSalmonellaEnteritidis Infections in Sporadic Diarrhea in Children: Source Tracing and Resistance to Third-Generation Cephalosporins and Ciprofloxacin

Cited by 34 publications

References 42 publications

Antimicrobial Resistance in Salmonella Serovars Isolated From an Egg-Producing Region in Brazil

Antimicrobial Resistance in Salmonella Serovars Isolated From an Egg-Producing Region in Brazil

Prevalence, serotypes, and antimicrobial resistance of Salmonella isolates from patients with diarrhea in Shenzhen, China

Etiology of acute diarrhea in children in Shanghai, 2015-2018

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