<i>Salvia miltiorrhiza</i>Lipophilic Fraction Attenuates Oxidative Stress in Diabetic Nephropathy through Activation of Nuclear Factor Erythroid 2-Related Factor 2

An, L.; Marikar, Faiz M. M. T.; Hu, Xuewen; Miao, Qiu-Yun; Li, Ping

doi:10.1142/s0192415x17500781

Cited by 19 publications

(9 citation statements)

References 47 publications

(31 reference statements)

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“…Evidence was recently reported that the ethyl acetate extract of Salvia miltiorrhiza (commonly known as Danshen) attenuates oxidative stress in the streptozotocin-treated mouse model of diabetic nephropathy via upregulated expression of Nrf2 (An et al, 2017 ). Triptolide, the main active ingredient of Tripterygium wilfordii Hook.…”

Section: Traditional Chinese Medicines For Treating Ckdmentioning

confidence: 99%

Oxidative Stress and Renal Fibrosis: Recent Insights for the Development of Novel Therapeutic Strategies

et al. 2018

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Chronic kidney disease (CKD) is a significant worldwide healthcare problem. Regardless of the initial injury, renal fibrosis is the common final pathway leading to end stage renal disease. Although the underlying mechanisms are not fully defined, evidence indicates that besides inflammation, oxidative stress plays a crucial role in the etiology of renal fibrosis. Oxidative stress results from an imbalance between the production of free radicals that are often increased by inflammation and mitochondrial dysfunction, and reduced anti-oxidant defenses. Several studies have demonstrated that oxidative stress may occur secondary to activation of transforming growth factor β1 (TGF-β1) activity, consistent with its role to increase nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox) activity. A number of other oxidative stress-related signal pathways have also been identified, such as nuclear factor erythroid-2 related factor 2 (Nrf2), the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP)-cGMP-dependent protein kinase 1-phosphodiesterase (cGMP-cGK1-PDE) signaling pathway, and the peroxisome proliferator-activated receptor gamma (PPARγ) pathway. Several antioxidant and renoprotective agents, including cysteamine bitartrate, epoxyeicosatrienoic acids (EETs), and cytoglobin (Cygb) have demonstrated ameliorative effects on renal fibrosis in preclinical or clinical studies. The mechanism of action of many traditional Chinese medicines used to treat renal disorders is based on their antioxidant properties, which could form the basis for new therapeutic approaches. This review focuses on the signaling pathways triggered by oxidative stress that lead to renal fibrosis and provides an update on the development of novel anti-oxidant therapies for CKD.

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Section: Traditional Chinese Medicines For Treating Ckdmentioning

confidence: 99%

Oxidative Stress and Renal Fibrosis: Recent Insights for the Development of Novel Therapeutic Strategies

et al. 2018

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“…Besides these pharmacological effects, a growing body of data indicated that SMRR potently activated intracellular antioxidant enzymes, upregulated endogenous antioxidants, and scavenged intracellular ROS. Therefore, SMRR demonstrated potential therapeutic effects against oxidative stress-induced diseases, such as cardiovascular diseases, inflammation, and renal disease [ 33 – 35 ].…”

Section: Salviae Miltiorrhizae Radix Et Rhizoma (Smrr)mentioning

confidence: 99%

“…Oxidative stress has been implicated in the onset and promotion of nephropathy, and the modulation of Nrf2 is an efficient strategy for the therapy of renal diseases [ 84 ]. Ethyl acetate extract of SMRR enhanced the expression of Nrf2 and inhibited ROS production in high-glucose-induced mouse mesangial cells (MMCs) [ 33 ]. It reduced albuminuria and alleviated renal damage in streptozocin-induced mice.…”

Section: Nrf2-based Therapeutic Potential Of Smrr and Its Constitumentioning

confidence: 99%

Therapeutic Potential of Salviae Miltiorrhizae Radix et Rhizoma against Human Diseases Based on Activation of Nrf2‐Mediated Antioxidant Defense System: Bioactive Constituents and Mechanism of Action

Jiao

et al. 2018

Oxidative Medicine and Cellular Longevity

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Oxidative stress plays a central role in the pathogenesis of many human diseases. The nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor regulating the intracellular antioxidant response and is an emerging target for the prevention and therapy of oxidative stress-related diseases. Salviae Miltiorrhizae Radix et Rhizoma (SMRR) is a traditional Chinese medicine (TCM) and is commonly used for the therapy of cardiac cerebral diseases. Cumulative evidences indicated that the extract of SMRR and its constituents, represented by lipophilic diterpenoid quinones and hydrophilic phenolic acids, were capable of activating Nrf2 and inhibiting oxidative stress. These bioactive constituents demonstrated a therapeutic potential against human diseases, exemplified by cardiovascular diseases, neurodegenerative diseases, diabetes, nephropathy, and inflammation, based on the induction of Nrf2-mediated antioxidant response and the inhibition of oxidative stress. In the present review, we introduced the SMRR and Nrf2 signaling pathway, summarized the constituents with an Nrf2-inducing effect isolated from SMRR, and discussed the molecular mechanism and pharmacological functions of the SMRR extract and its constituents.

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“… 160 For instance, Tanshinone IIA, a di-terpenoid isolated from SM, showed antioxidant benefit by activating the Nrf2 signaling pathway, improving the metabolic profile and exhibiting potent renoprotective effects, 160 and the lipophilic fraction attenuated oxidative stress in diabetic nephropathy. 161 …”

Section: Resultsmentioning

confidence: 99%

Promoting Plant-Based Therapies for Chronic Kidney Disease

Khan

Kassianos

Hoy

et al. 2022

J Evid Based Complementary Altern Med

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Chronic kidney disease (CKD) is debilitating, increasing in incidence worldwide, and a financial and social burden on health systems. Kidney failure, the final stage of CKD, is life-threatening if untreated with kidney replacement therapies. Current therapies using commercially-available drugs, such as angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers and calcium channel blockers, generally only delay the progression of CKD. This review article focuses on effective alternative therapies to improve the prevention and treatment of CKD, using plants or plant extracts. Three mechanistic processes that are well-documented in CKD pathogenesis are inflammation, fibrosis, and oxidative stress. Many plants and their extracts are already known to ameliorate kidney dysfunction through antioxidant action, with subsequent benefits on inflammation and fibrosis. In vitro and in vivo experiments using plant-based therapies for pre-clinical research demonstrate some robust therapeutic benefits. In the CKD clinic, combination treatments of plant extracts with conventional therapies that are seen as relatively successful currently may confer additive or synergistic renoprotective effects. Therefore, the aim of recent research is to identify, rigorously test pre-clinically and clinically, and avoid any toxic outcomes to obtain optimal therapeutic benefit from medicinal plants. This review may prove to be a filtering tool to researchers into complementary and alternative medicines to find out the current trends of using plant-based therapies for the treatment of kidney diseases, including CKD.

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Salvia miltiorrhizaLipophilic Fraction Attenuates Oxidative Stress in Diabetic Nephropathy through Activation of Nuclear Factor Erythroid 2-Related Factor 2

Cited by 19 publications

References 47 publications

Oxidative Stress and Renal Fibrosis: Recent Insights for the Development of Novel Therapeutic Strategies

Oxidative Stress and Renal Fibrosis: Recent Insights for the Development of Novel Therapeutic Strategies

Therapeutic Potential of Salviae Miltiorrhizae Radix et Rhizoma against Human Diseases Based on Activation of Nrf2‐Mediated Antioxidant Defense System: Bioactive Constituents and Mechanism of Action

Promoting Plant-Based Therapies for Chronic Kidney Disease

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