<i>Saururus chinensis-</i>controlled allergic pulmonary disease through NF-κB/COX-2 and PGE<sub>2</sub> pathways

Song, Mi‐Kyung; Lee, Soon-Young; Kim, Minhee; Park, Sangwoug; Park, Juyeon; Kwon, Yongbum; Park, Dae-Hun

doi:10.7717/peerj.10043

Cited by 5 publications

(3 citation statements)

References 34 publications

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“…Pinus maritime decreased inflammation by enhancing the HO-1 antioxidative system and suppressing the levels of proinflammatory cytokines such as IL-1β and IL-6 [99]. Saururus chinensis, a culinary material, inhibited inflammation by blocking NF-κB activation and the expression of COX-2 and PEG 2 [100].…”

Section: Anti-inflammatory Effectorsmentioning

confidence: 99%

Drug Development from Natural Products Based on the Pathogenic Mechanism of Asthma

Kim,

Bae,

Bok

et al. 2023

IJMS

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Asthma is a chronic inflammatory disease of the pulmonary system associated with many wheeze-to-sleep apnea complications that may lead to death. In 2019, approximately 262 million patients suffered from asthma, and 455 thousand died from the disease worldwide. It is a more severe health problem in children and older adults, and as the aging of society intensifies, the problem will continue to worsen. Asthma inducers can be classified as indoor and outdoor allergens and can cause asthma due to their repeated invasion. There are several theories about asthma occurrence, such as the imbalance between Th1 and Th2, inflammation in the pulmonary system, and the abnormal apoptosis/cell proliferation of cells related to asthma. Although there are many medications for asthma, as it is an incurable disease, the purpose of the drugs is only to suppress the symptoms. The current drugs can be divided into relievers and controllers; however, as they have many adverse effects, such as immune suppression, growth retardation, promotion of cataracts, hyperactivity, and convulsions, developing new asthma drugs is necessary. Although natural products can have adverse effects, the development of asthma drugs from natural products may be beneficial, as some have anti-asthmatic effects such as immune modulation, anti-inflammation, and/or apoptosis modulation.

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Section: Anti-inflammatory Effectorsmentioning

confidence: 99%

Drug Development from Natural Products Based on the Pathogenic Mechanism of Asthma

Kim,

Bae,

Bok

et al. 2023

IJMS

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“…The role of cyclooxygenase in the development of tumors has therefore focused on COX‐2, a protein that is thought to be a proto‐oncoprotein (Consalvi et al, 2015). This protein can promote high expression of PGE‐2, which can stimulate the induction of tumor vascular hyperplasia, inhibit local immune function, regulate a variety of signaling pathways, and affect cell proliferation and promote tumor cell growth (Song et al, 2020). Inhibition of COX‐2 reduces the division of tumor cells, increases their mortality, and inhibits the production of blood vessels in tumor cells, reflecting significant anti‐tumor effects (Dempke et al, 2001; Rizzo, 2011; Yusup et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Recent progress of research on anti‐tumor agents using benzimidazole as the structure unit

Peng

Chen

et al. 2022

Chem Biol Drug Des

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With the development of exploration for disease‐related proteins or receptors, more and more novel structural lead compounds are required to designed and synthesized. The benzimidazole is an effective structural unit in which the benzene ring is fused at the 4 and 5 positions of the imidazole ring and wildly used in drug design. Here, we introduce some recent progress of research for anti‐tumor agents which was target to various target proteins such as DNA topoisomerase, angiogenesis, serine/threonine protein kinase, and tyrosine protein kinase. These anti‐tumor agents are all introduced benzimidazole as the structure unit. Further docking study showed that the benzimidazole group was not only act as a skeleton to expand the structure of molecule but also as an excellent ligand unit to form hydrogen bond or π–π conjugation and hydrophobic interaction with target proteins or receptors. We expect that introducing benzimidazole in the chemical structure could be a reasonable and priority strategy in novel anti‐tumor agents' design.

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“…Moreover, flavonoids play an anti-inflammatory role by inhibiting the activity of inflammatory immune cells, suppressing the production and expression of inflammatory genes and mediators and by regulating inflammation-related signaling pathways [8,9]. In addition, the flavonoid monomeric compound, QUE, could also recover pulmonary epithelial cell hyperplasia, and inflammatory cell infiltration improved via the tNF-κB/COX-2 and PGE2 signaling pathway [10].…”

Section: Introductionmentioning

confidence: 99%

Intervening Effects and Molecular Mechanism of Quercitrin on PCV2-Induced Histone Acetylation, Oxidative Stress and Inflammatory Response in 3D4/2 Cells

et al. 2022

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Porcine circovirus type 2 (PCV2) is the main pathogen causing porcine circovirus-associated diseases (PCVD/PCVADs), and infection of the host induces immunosuppression. Since quercitrin (QUE) has anti-inflammatory and antiviral activity, it is worth exploiting in animal diseases. In this study, the interventional effects and the molecular mechanism of QUE on PCV2-induced oxidative stress and inflammatory responses in 3D4/2 cells and the modulation of histone acetylation modifications were investigated. The ROS production was measured by DCFH-DA fluorescent probes. HAT and HDAC enzyme activity were determined by ELISA. Histone acetylation, oxidative stress and inflammation-related gene expression levels were measured by q-PCR. Histone H3 and H4 (AcH3 and AcH4) acetylation, oxidative stress and inflammation-related protein expression levels were measured by Western blot. The results showed that QUE treatment at different concentrations on PCV2-infected 3D4/2 cells was able to attenuate the production of ROS. Moreover, QUE treatment could also intervene in oxidative stress and decrease the enzyme activity of HAT and the mRNA expression level of HAT1, while it increased the enzyme activity of HDAC and HDAC1 mRNA expression levels and downregulated histone H3 and H4 (AcH3 and AcH4) acetylation modification levels. In addition, QUE treatment even downregulated the mRNA expression levels of IL-6, IL-8, IκB, AKT and p38, but upregulated the mRNA expression levels of IL-10, SOD, GPx1, p65, Keap1, Nrf2, HO-1 and NQO1. As to protein expression, QUE treatment downregulated the levels of iNOS, p-p65 and IL-8 as well as the phosphorylation expression of IκB and p38, while it upregulated the levels of HO-1 and NQO1. It was shown that QUE at 25, 50 or 100 μmol/L regulated p38MAPK and PI3K/AKT signaling pathways by downregulating cellular histone acetylation modification levels while inhibiting the NF-κB inflammatory signaling pathway and activating the Nrf2/HO-1 antioxidant signaling pathway, thus regulating the production of inflammatory and antioxidant factors and exerting both anti-inflammatory and antioxidant effects.

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Saururus chinensis-controlled allergic pulmonary disease through NF-κB/COX-2 and PGE₂ pathways

Cited by 5 publications

References 34 publications

Drug Development from Natural Products Based on the Pathogenic Mechanism of Asthma

Drug Development from Natural Products Based on the Pathogenic Mechanism of Asthma

Recent progress of research on anti‐tumor agents using benzimidazole as the structure unit

Intervening Effects and Molecular Mechanism of Quercitrin on PCV2-Induced Histone Acetylation, Oxidative Stress and Inflammatory Response in 3D4/2 Cells

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Saururus chinensis-controlled allergic pulmonary disease through NF-κB/COX-2 and PGE2 pathways

Cited by 5 publications

References 34 publications

Drug Development from Natural Products Based on the Pathogenic Mechanism of Asthma

Drug Development from Natural Products Based on the Pathogenic Mechanism of Asthma

Recent progress of research on anti‐tumor agents using benzimidazole as the structure unit

Intervening Effects and Molecular Mechanism of Quercitrin on PCV2-Induced Histone Acetylation, Oxidative Stress and Inflammatory Response in 3D4/2 Cells

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Saururus chinensis-controlled allergic pulmonary disease through NF-κB/COX-2 and PGE₂ pathways