<i>Scedosporium apiospermum</i>: changing clinical spectrum of a therapy-refractory opportunist*

Guarro, Josep; Kantarcıoğlu, A. Serda; Horré, R.; Rodríguez-Tudela, Juan Luis; Estrella, Manuel Cuenca; Berenguer, Juan; Hoog, G. Sybren de

doi:10.1080/13693780600752507

Cited by 274 publications

(339 citation statements)

References 295 publications

(322 reference statements)

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“…6,16 Systemic diseases caused by S. apiospermum have been referred to as allescheriasis, graphitosis, monosporiosis, petriellidiosis, pseudallescheria, pseudallescheriasis, or scedosporiosis. 10 This organism is now recognized as a potent and emerging pathogen of severe infection in immunosuppressed human patients.…”

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confidence: 99%

“…17 In humans, the clinical presentation of scedosporiosis is largely dependent on the fungal strain, portal of entry, and immune status of the patient. 3,10 Three clinical syndromes can be distinguished: 1) localized disease after trauma, such as subcutaneous mycetoma, arthritis, osteomyelitis, endophthalmitis, or onychomycosis; 2) large asymptomatic or symptomatic colonization of cavities, mainly pulmonary cases, but also sinusitis or otitis; and 3) invasive systemic diseases such as pneumonia, endocarditis, or central nervous system disorders. 10 Classically, S. apiospermum has been implicated in subcutaneous infections and asymptomatic pulmonary colonization.…”

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confidence: 99%

“…3,10 Three clinical syndromes can be distinguished: 1) localized disease after trauma, such as subcutaneous mycetoma, arthritis, osteomyelitis, endophthalmitis, or onychomycosis; 2) large asymptomatic or symptomatic colonization of cavities, mainly pulmonary cases, but also sinusitis or otitis; and 3) invasive systemic diseases such as pneumonia, endocarditis, or central nervous system disorders. 10 Classically, S. apiospermum has been implicated in subcutaneous infections and asymptomatic pulmonary colonization. Systemic infections are more frequently observed in patients with an impaired immune system or in victims of near drowning 10 ; however, infections also have been documented in immunocompetent patients.…”

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confidence: 99%

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Osteomyelitis and Discospondylitis due to Scedosporium Apiospermum in a Dog

Hugnet¹,

Marrou²,

Dally

et al. 2009

J VET Diagn Invest

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Abstract. A 6-year-old, 30-kg, female German Shepherd Dog, living in a leishmaniasis enzootic area, was presented with a severe rear limb motor disorder and a medical history of acute onset of fever. Routine hematology indicated neutrophilia. Spinal survey radiographs were consistent with osteomyelitis and discospondylitis. Because of the poor clinical prognosis and the painful nature of the lesions, the dog was euthanized at the owners' request. At necropsy, T13-L1 vertebrae had large areas of necrosis within the vertebral bodies. Histopathological findings were consistent with chronic, severe, fungal osteomyelitis and discospondylitis. Polymerase chain reaction identified Scedosporium apiospermum, a eutrophic filamentous fungus now recognized as an emerging agent of severe infections in immunosuppressed human patients.

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Osteomyelitis and Discospondylitis due to Scedosporium Apiospermum in a Dog

Hugnet¹,

Marrou²,

Dally

et al. 2009

J VET Diagn Invest

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“…28,49 Scedosporium apiospermum (Figure 4) also may cause colonization and infection of the respiratory tract in persons with predisposing conditions, systemic invasive disease (usually in immunocompromised hosts) and keratitis, and has rarely been associated with otitis externa. 28,50 Common superficial fungal infections also may rarely result from freshwater exposure. Dermatophytes and other keratinophilic fungi have been reported in freshwater and sources of drinking water.…”

Section: Other Specific Infections Occasionally Linked To Freshwatermentioning

confidence: 99%

Freshwater Fungal Infections

Baumgardner

2017

Journal of Patient-Centered Research and Reviews

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“…The most frequent causing agents of such infections are Candida, Aspergillus species, Cryptococcus neoformans, Mucor and some unusual genera such as Fusarium, Trichosporon, and Scedosporium (Guarro et al, 2006;Nucci & Anaissie, 2007). Furthermore, the most common treatment for these infectious diseases involves azoles and polyene macrolides, which are limited in their spectrum, and presenting severe side effects (Helmerhorst et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of Pterogyne nitens Tul., Fabaceae, against opportunistic fungi

Regasini¹,

Pivatto

Scorzoni³

et al. 2010

Rev. bras. farmacogn.

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RESUMO: "Atividade antimicrobiana de Pterogyne nitens Tul., Fabaceae, contra fungos oportunistas". No contexto de nossas pesquisas por novos agentes antifúngicos obtidos da flora brasileira, oito extratos e doze frações de Pterogyne nitens Tul., Fabaceae, foram submetidos ao ensaio antifúngico pelo método de microdiluição, contra quatro espécies de fungos oportunistas, Candida albicans, Candida krusei, Candida parapsilosis e Cryptococcus neoformans. Este trabalho revelou que os extratos e frações de P. nitens foram mais ativos contra C. krusei e C. parapsilosis quando comparados a C. neoformans, sendo que o crescimento de C. albicans foi moderadamente afetado por todos os extratos e frações. As atividades mais potentes foram observadas para as frações n-butanólica dos galhos (CIM = 15,6 µg/mL) e raízes (CIM = 31,2 µg/mL) contra C. krusei. Adicionalmente, a fração n-butanólica dos galhos foi submetida ao fracionamento cromatográfico, resultando no isolamento de quatro alcaloides guanidínicos, sendo N-1,N-2,N-3-triisopentenilguanidina (1), descrito pela primeira vez em espécies da família Fabaceae e nitensidinas A-C (2-4), os quais apresentaram atividade antifúngica moderada contra C. krusei (CIM = 62,5 µg/ mL) e C. parapsilosis (CIM = 31,2 µg/mL). Unitermos:Pterogyne nitens, alcaloides guanidínicos, antifúngico, fungos oportunistas, Candida spp., Cryptococcus neoformans. ABSTRACT:As part of our ongoing research on antifungal agents from Brazilian flora, eight extracts and twelve fractions from Pterogyne nitens Tul., Fabaceae, were screened for antimicrobial activity against four opportunistic fungi species (Candida albicans, Candida krusei, Candida parapsilosis and Cryptococcus neoformans) using a broth microdilution method. The present investigation reveals that P. nitens extracts and fractions were more effective against C. krusei and C. parapsilosis than against C. neoformans. The growth of C. albicans was moderately affected by all tested extracts and fractions. The strongest effects were observed for n-butanol fractions from branches (MIC = 15.6 µg/mL) and roots (MIC = 31.2 µg/mL) against C. krusei. Additionally, the chromatographic fractionation of the n-butanol fraction from branches afforded four guanidine alkaloids; N-1,N-2,N-3-triisopentenylguanidine (1), described for the first time in the Fabaceae family, and nitensidines A-C (2-4), which showed moderate activity towards C. krusei (MIC = 62.5 µg/mL) and C. parapsilosis (MIC = 31.2 µg/mL).

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Scedosporium apiospermum: changing clinical spectrum of a therapy-refractory opportunist*

Cited by 274 publications

References 295 publications

Osteomyelitis and Discospondylitis due to Scedosporium Apiospermum in a Dog

Osteomyelitis and Discospondylitis due to Scedosporium Apiospermum in a Dog

Freshwater Fungal Infections

Antimicrobial activity of Pterogyne nitens Tul., Fabaceae, against opportunistic fungi

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