<i><scp>H</scp>elicobacter pylori</i> infection associated with high <scp>H</scp>b<scp>A</scp>1c and type 2 diabetes

Hsieh, Ming‐Chia; Wang, Sophie S.W.; Hsieh, Yi‐Ting; Kuo, Fu‐Chen; Soon, Maw–Soan; Wu, Deng‐Chyang

doi:10.1111/eci.12124

Cited by 77 publications

(70 citation statements)

References 38 publications

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“…Hsiech et al found that the HbA1c levels of Hp positive patients were significantly higher than those of Hp negative in their study including 2060 patients in China. Also, in that study, type 2 diabetes frequency was significantly higher in the Hp-positive group [8].…”

Section: Resultsmentioning

confidence: 51%

“…Considering from another respect, DM was observed to be more prevalent in Hp-positive patients in the study by Han et al which included 30810 patients and was completed in 2015 in China (21.3% and 20.2%, p=0.026) [6]. Also, numerous studies including large patient populations revealed that the HbA1c levels of Hp-positive diabetic patients were higher than that of Hp-negative diabetic patients, suggesting that bacterial infection may have had a negative effect on blood glucose regulation in infected patients [7,8]. We investigated whether there is any significant difference in metabolic control namely HbA1c levels among the patients having diabetes with dyspeptic complaints who underwent endoscopy.…”

Section: Introductionmentioning

confidence: 99%

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Dyspeptic Symptoms in Patients with Type 2 Diabetes Mellitus: Helicobacter pylori Infection and Its Associations with Metabolic Control

Böyük¹,

Kilicaslan²,

Çelebi³

et al. 2017

J Gastrointest Dig Syst

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Aim: Helicobacter pylori (Hp) is the causative agent of the most common chronic infection in the world. The close association of Hp with gastric and duodenal ulcer, gastric cancer and MALToma has been proven. Besides, there are numerous studies reporting the coexistence of Hp with diabetes mellitus, coronary artery disease, idiopathic thrombocytopenic purpura, and iron deficiency anemia. Material-Methods:This study was conducted on 205 diabetic patients including 75 male and 130 female individual with dyspeptic complaints. The endoscopic biopsy specimens of these patients were investigated for the presence of Hp. Also, histochemical examinations were carried out. The patients were divided into two groups, namely, Hp-positive and Hp -negative group. The Helicobacter pylori positive group was divided into three subgroups as follows based on their bacterial intensity: Hp density-1, Hp density-2, Hp density-3 groups to compare metabolic parameters between subgroups.Results: A total of 205 diabetic patients enrolled in the study. The mean HbA1c levels of the patients without Hp was 7.59 ± 1.66 while that of the patients with Hp was found to be 7.57 ± 1.77. No statistically significant difference was detected between these two groups. Likewise, no statistically significant difference was observed in terms of HbA1c levels among the groups when they were classified according to Hp density. Conclusion:In this study, we investigated metabolic outcomes of the coexistence of two commonly occurring entities, a chronic infection and a chronic disease. No relationship was detected regarding the presence of Helicobacter pylori and its intensity with the metabolic parameters mainly the HbA1c levels of diabetic people.

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Section: Resultsmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Dyspeptic Symptoms in Patients with Type 2 Diabetes Mellitus: Helicobacter pylori Infection and Its Associations with Metabolic Control

Böyük¹,

Kilicaslan²,

Çelebi³

et al. 2017

J Gastrointest Dig Syst

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“…pylori infection is reported to be associated with insulin resistance, diabetes mellitus and metabolic syndrome [74][75][76] . Compared to non-diabetics with HPI, the levels of oxidative DNA damage (8-OHdG) in type 2 diabetes mellitus could be much higher (p = 0.001).…”

Section: Diabetes Mellitusmentioning

confidence: 99%

“…There were significant differences of fasting blood glucose, high-density lipoprotein cholesterol between HPI patients and healthy controls [75] . Hsieh et al reported that long-term HPI was significantly associated with increased levels of HbA1c and decreased insulin secretion in Chinese population [76] .…”

Section: Diabetes Mellitusmentioning

confidence: 99%

Helicobacter Pylori Infection Associated Diseases – A Systematic Review

2017

Med One

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Helicobacter pylori (H. pylori) infection (HPI) is one of the most widespread diseases. More than half of world population is affected by HPI, especially children in developing countries. The associations between many gastrointestinal diseases and HPI have been found in clinical. Also, there are some diseases whose HPI associations are controversial and unclear. Due to its unclear disease association, H. pylori test is not included in the clinical screening. However, some pre-clinical studies showed possible associations between HPI and these diseases, involving pathological changes of different functional systems of the human body (e.g., Immune system, cerebrovascular system). Therefore, for HPI patients, more attention should be paid to the possible risks of these diseases. In this study, a systematic literature review was conducted to identify and classify H. pylori related diseases. This review identified 175 HPI related diseases belonging to 9 categories, and summarized the corresponding supporting literature reports. In addition, the functional mechanisms underlying the linkages between HPI and 28 well studied diseases were discussed, revealing possible pathogenesis for these diseases. We conclude that HPI is related to many serious diseases affecting multiple important human systems, and clinical HPI treatment and HPI test might help the detection and treatment of these diseases. Our results guarantee further study using more data to testify the possible relations between HPI and these diseases.

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“…Proper screening for Hp infection combined with regular monitoring of blood glucose and HbA1c levels might be effective for the early detection of glucose dysregulation and prevention of T2DM [25]. An analysis performed on 5889 subjects showed that metabolic syndrome was more strongly associated with histologic positivity for Hp than serologic positivity, after adjusting for age, sex, smoking status, alcohol consumption, and economic status.…”

Section: Metabolic Changes In Hp With T2dmmentioning

confidence: 99%

Untitled

2016

Russ. Open Med. J.

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Abstract:The incidence and prevalence of type 2 diabetes mellitus is considered to be one of the most critical problems in the healthcare system. The pathophysiology of the disease has proven to be complicated and multiple factors are involved in its development. Recently Helicobacter pylori was proposed as a new risk factor for developing type 2 diabetes mellitus as well as other disease. This study is a review of the current data involving Helicobacter pylori association with type 2 diabetes mellitus and its complications.

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Helicobacter pylori infection associated with high HbA1c and type 2 diabetes

Cited by 77 publications

References 38 publications

Dyspeptic Symptoms in Patients with Type 2 Diabetes Mellitus: Helicobacter pylori Infection and Its Associations with Metabolic Control

Dyspeptic Symptoms in Patients with Type 2 Diabetes Mellitus: Helicobacter pylori Infection and Its Associations with Metabolic Control

Helicobacter Pylori Infection Associated Diseases – A Systematic Review

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