HLA‐C*12:02 is a susceptibility factor in late‐onset type of psoriasis in Japanese

Abstract

Psoriasis is thought to be a multifactorial disease triggered by both genetic and environmental factors. The HLA-C locus on chromosome 6p21.33 remains the strongest susceptibility candidate locus in psoriasis. The strong association between psoriasis and the HLA-Cw6 allele has been well documented in various races. It is known that psoriatic patients with early onset are more likely to be familial and associated with HLA-Cw6. Familial occurrence of Japanese psoriasis is smaller than other populations. Furthermore, males are predominant over females in Japanese psoriasis. We investigated the relation between HLA-C alleles and age of onset, and in each gender for Japanese psoriasis, and discuss male predominance in the incidence of psoriasis in Japan. Four hundred forty six unrelated Japanese patients with psoriasis vulgaris and 557 sex- and age-matched unrelated Japanese healthy controls were investigated by genotyping. We confirmed the association between early-onset type of psoriasis with HLA-C*06:02 allele in Japanese. In addition, we detected the association between the late-onset type of psoriasis and the HLA-C*12:02 allele in Japanese. No significant differences in allele frequency were observed between females and males. Our results suggest that there is no genetic factor effect on male predominance in Japanese. In contract, the effect of environmental risk factors on the onset of Japanese psoriatic patients is stronger in males than in females. As a result, male predominant in psoriasis may occur in Japan.

Human Leukocyte Antigen-Class I Alleles and the Autoreactive T Cell Response in Psoriasis Pathogenesis

“…This highlights the need to use population-specific reference panels made by deep sequencing to impute MHC alleles and amino acids ( 8 ). The strong psoriasis risk of HLA-C*06:02 allele has been validated in worldwide populations including Europeans ( 17 , 20 ), East ( 6 , 21 ), and South Asians ( 22 ), with odds ratios of as high as 3.0–10.0. HLA fine-mapping analysis using the HLA imputation method successfully identified multiple other less obviously associated HLA-class I and class II variants that confer psoriasis risk independently from HLA-C*06:02 ( 20 ).…”

Cardiovascular and Metabolic Diseases Comorbid with Psoriasis: Beyond the Skin

“…As mentioned above, psoriasis is a chronic inflammatory skin disease driven by the TNF-α/IL-23/IL-17 axis (1, 4, 10). This notion is well supported by the high clinical efficacy of biologics against the TNF-α/IL-23/IL-17 pathway (5, 8, 15, 66).…”

Limited clinical utility of HLA-Cw6 genotyping for outcome prediction in psoriasis patients under ustekinumab therapy: a monocentric, retrospective analysis

“…More than 36 genetic loci are associated with psoriasis, 1 and of these, HLA-C * 06, also known as HLA-Cw6 or PSORS1 (6p21.33), has the strongest disease association. 2 – 4 HLA-Cw6+ patients tend to have an earlier onset of disease and more severe manifestations. 5 – 8 Previous studies have suggested that HLA-Cw6 genotyping could possibly play a role in predicting therapy outcome to the interleukin-12/23 antagonist, ustekinumab, making pharmacogenomics a promising field of research.…”