<i><scp>MYB</scp></i> rearrangement and immunohistochemical expression in adenomyoepithelioma of the breast: a comparison with adenoid cystic carcinoma

Baraban, Ezra; Zhang, Paul J.; Jaffer, Shabnam; Lubin, Daniel; Feldman, Michael D.; Bleiweiss, Ira J.; Nayak, Anupma

doi:10.1111/his.13708

Cited by 14 publications

(21 citation statements)

References 21 publications

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“…Pathologically, they are characterized by a biphasic proliferation of both cell populations. There is a spectrum of histological patterns depending on the distribution of proliferating glandular cells, prominence of the papillary and fibrotic components, and the morphology of the myoepithelial cells [ 9 ]; thus, defining the tumor as papillary, lobulated, tubular, or with mixed architectural pattern [ 11 ]. Biologically, the majority of the tumors are benign, however, either the epithelial or he myoepithelial component or both, might undergo malignant transformation.…”

Section: Discussionmentioning

confidence: 99%

“…In a study conducted by Erza et al the tumor is reported as “AME with malignant transformation”, or “malignant AME” if the tumor exhibited overgrowth of either component, severe atypia, infiltrative growth pattern, increased mitotic activity, and/or necrosis. Tumors that do not possess all features were classified as “Atypical AME” [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

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Breast adenomyoepithelioma, a case report

El-Helou

Terro

Kansoun

et al. 2020

International Journal of Surgery Case Reports

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Highlights Adenomyoepithelioma is a rare tumor of the breast characterized by a biphasic proliferation. Variable spectrum of behavior ranging from benign to malignant, with tendency to local recurrence. Combine sentinel lymph node dissection (SLND), with simple mastectomy. Hematogenous spread is the more common means of spread. Adjuvant chemotherapy for malignant AME cases is recommended.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Breast adenomyoepithelioma, a case report

El-Helou

Terro

Kansoun

et al. 2020

International Journal of Surgery Case Reports

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“…At least 100 non-overlapping interphase tumor cell nuclei per case were counted initially. A case was considered positive only if >15 of 100 cells rearranged ( 14 ).…”

Section: Methodsmentioning

confidence: 99%

Histo- and clinico-pathological analysis of a large series of triple-negative breast cancer in a single center in China: Evidences on necessity of histological subtyping and grading

Zhang

Huang

Zhang

et al. 2020

Chinese Journal of Cancer Research

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Objective To investigate histo-pathological distribution and clinico-pathological significance in a large Chinese triple-negative breast cancer (TNBC) patients serials based on the latest understanding of its clinico-pathological diversity, and to provide more information to clinicians to improve precision of individualized treatment of TNBC. Methods A retrospective analysis was performed on patients with TNBC at Breast Disease Center, Peking University First Hospital between January 2010 and December 2019. Histo- and clinico-pathological characteristics were analyzed by Chi-square test and Student’s t -test, and prognoses were calculated using Kaplan-Meier method and a Cox proportionate hazards model. Bonferroni correction was used to correct for multiple comparison. Results Conventional type of TNBC (cTNBC) were identified in 73.7% of 582 TNBC, while special type of TNBC (sTNBC) were 26.3%, including 71 apocrine carcinoma, 20 medullary carcinoma, 31 metaplastic carcinoma, 18 invasive lobular carcinoma, 7 invasive micropapillary carcinoma, 5 adenoid cystic carcinoma and 1 acinic cell carcinoma. Compared to sTNBC, cTNBC was associated with high histologic grade (P<0.001) and lower androgen receptor (AR) expression (P<0.001). TNM stage of low-grade cTNBC was significantly lower than that of high-grade cTNBC (P=0.002). Although no significant difference, there was a trend that the rate of 5-year disease-free survival (DFS) and 5-year overall survival (OS) were longer in high-grade cTNBC than in high-grade sTNBC (P=0.091 and 0.518), and were longer in low-grade sTNBC than in high-grade sTNBC (P=0.051 and 0.350). Metaplastic carcinomas showed larger tumor size (P=0.008) and higher proliferative Ki67 index (P=0.004) than cTNBCs. Conclusions Results from our cohort imply that sub-categorization or subtyping and histological grading could be meaningful in pathological evaluation of TNBC, and need to be clarified in more large collections of TNBC.

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“…Using a three-tiered approach, AME has been classified by some authors as benign, infiltrating and malignant. 12,[26][27][28] Later, the term 'atypical AME' was proposed as an alternative to infiltrating AME, with stromal infiltration not a diagnostic prerequisite 12,29,30 These atypical AMEs display clinical behaviour intermediate between benign and malignant AME 30,31 and show an intermediate immunoprofile, termed 'borderline AME' by some authors. 6 However, precise categorisation of AME remains challenging.…”

Section: Adenomyoepithelioma H I S T O R I C a L O V E R V I E Wmentioning

confidence: 99%

Adenomyoepithelioma of the breast: a proposal for classification

et al. 2021

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Breast lesions with a prominent myoepithelial cell component constitute a heterogeneous group of benign and malignant neoplastic proliferations. These lesions are often dual epithelial-myoepithelial, but may be purely myoepithelial cell in nature. Benign epithelial-myoepithelial lesions typically maintain the morphology and immunophenotype of the normal bilayer epithelial myoepithelial structures. However, the distinction between the two cell components is not always clear-cut in malignant lesions in which the histogenesis of myoepithelial cells remains uncertain. Neoplastic biphasic epithelial-myoepithelial lesions of the breast include adenomyoepithelioma (AME), pleomorphic adenoma and adenoid cystic carcinoma. Four histological patterns of classical AME have been described: tubular, lobulated, spindle-cell and adenosis variants. Overlapping patterns occur and some AMEs display an intraductal papillary pattern that may represent a fifth variant. AME can be benign or malignant. Classical AME may show atypical features, which are not sufficient for the diagnosis of malignancy (atypical AME). Atypical AME is recognised as a lesion of uncertain malignant potential with limited metastatic capability. Based on the histological features, we propose a classification of malignant AME (M-AME) into three variants: M-AME in situ, M-AME invasive and AME with invasive carcinoma. In this review, we provide an overview of myoepithelial lesions of the breast focusing on the classification of AME to improve not only the consistency of reporting but also help to guide further management decision-making.

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MYB rearrangement and immunohistochemical expression in adenomyoepithelioma of the breast: a comparison with adenoid cystic carcinoma

Cited by 14 publications

References 21 publications

Breast adenomyoepithelioma, a case report

Breast adenomyoepithelioma, a case report

Histo- and clinico-pathological analysis of a large series of triple-negative breast cancer in a single center in China: Evidences on necessity of histological subtyping and grading

Adenomyoepithelioma of the breast: a proposal for classification

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