<scp>TLR</scp>2,<scp>TLR</scp>4 and <scp>CD</scp>86 gene polymorphisms in recurrent aphthous stomatitis

Karasneh, Jumana; Hani, Maisoun Bani; Alkhateeb, Asem; Hassan, Ahmed; Alzoubi, Firas

doi:10.1111/jop.12298

Cited by 24 publications

(18 citation statements)

References 31 publications

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“…These authors also identified a correlation between the serotonin transcriptase encoding gene polymorphisms and recurrent aphthous ulceration, implicating the potential role of stress and psychogenic stimuli in ulcer development 35. Karasneh and colleagues recently demonstrated the likely relationship between toll‐like receptor 4 rs10759931 polymorphism and recurrent aphthous ulceration 36. They note that future studies would be valuable relative to potentially targeting the toll‐like receptor as a treatment strategy for the lesion 36.…”

Section: Phenotype Incidence and Pathobiology Of Mtor Inhibitor–assmentioning

confidence: 99%

“…Until further research determines the molecular basis of mIAS, it is thus biologically plausible to conceptualize a pathobiologic model of mIAS in relation to the multifactorial mechanistic basis and clinical profile of recurrent aphthous ulceration as defined in the literature (Table 2) 7, 9, 10, 30, 31, 32, 33, 34, 35, 36, 37. Possible risk factors for recurrent aphthous ulceration have classically included anxiety and stress, hormonal alteration, and/or nutritional deficiency.…”

Section: Phenotype Incidence and Pathobiology Of Mtor Inhibitor–assmentioning

confidence: 99%

“…Karasneh and colleagues recently demonstrated the likely relationship between toll‐like receptor 4 rs10759931 polymorphism and recurrent aphthous ulceration 36. They note that future studies would be valuable relative to potentially targeting the toll‐like receptor as a treatment strategy for the lesion 36.…”

Section: Phenotype Incidence and Pathobiology Of Mtor Inhibitor–assmentioning

confidence: 99%

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Oral mucosal injury caused by mammalian target of rapamycin inhibitors: emerging perspectives on pathobiology and impact on clinical practice

et al. 2016

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In recent years oral mucosal injury has been increasingly recognized as an important toxicity associated with mammalian target of rapamycin (mTOR) inhibitors, including in patients with breast cancer who are receiving everolimus. This review addresses the state‐of‐the‐science regarding mTOR inhibitor‐associated stomatitis (mIAS), and delineates its clinical characteristics and management. Given the clinically impactful pain associated with mIAS, this review also specifically highlights new research focusing on the study of the molecular basis of pain. The incidence of mIAS varies widely (2–78%). As reported across multiple mTOR inhibitor clinical trials, grade 3/4 toxicity occurs in up to 9% of patients. Managing mTOR‐associated oral lesions with topical oral, intralesional, and/or systemic steroids can be beneficial, in contrast to the lack of evidence supporting steroid treatment of oral mucositis caused by high‐dose chemotherapy or radiation. However, steroid management is not uniformly efficacious in all patients receiving mTOR inhibitors. Furthermore, technology does not presently exist to permit clinicians to predict a priori which of their patients will develop these lesions. There thus remains a strategic need to define the pathobiology of mIAS, the molecular basis of pain, and risk prediction relative to development of the clinical lesion. This knowledge could lead to novel future interventions designed to more effectively prevent mIAS and improve pain management if clinically significant mIAS lesions develop.

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Section: Phenotype Incidence and Pathobiology Of Mtor Inhibitor–assmentioning

confidence: 99%

Section: Phenotype Incidence and Pathobiology Of Mtor Inhibitor–assmentioning

confidence: 99%

Section: Phenotype Incidence and Pathobiology Of Mtor Inhibitor–assmentioning

confidence: 99%

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Oral mucosal injury caused by mammalian target of rapamycin inhibitors: emerging perspectives on pathobiology and impact on clinical practice

et al. 2016

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“…Up to my best knowledge by the time of writing this manuscript (08/11/2019), no articles were found in Pubmed-NCBI data base when searching for key words as 'TLR4 SNP Iraq'. Although, when searched for 'TLR4 polymorphism Iraq' only one article was published that was about TLR4 Asp299Gly SNP (rs4986790) and the samples were taken from Jordanian populations but one of its authors is from Iraq [15] . Similarly, no data were found for TLR4 SNP in Syria as a country of having Kurdish populations.…”

Section: Resultsmentioning

confidence: 99%

Genetic Polymorphism of Toll-Like Receptor 4 Thr399Ile Variant in Iraqi Kurdish Population: Sulaymaniyah Province

Niranji

2020

passer

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Toll-like receptors (TLRs), encoded by innate immune genes, functions to detect microbial ligands. Studies found that polymorphisms in TLR genes among populations are associated with diseases. Among the classes of TLRs, TLR-4 is important for exploring bacterial lipopolysaccharide. TLR-4 Thre399Ile is one of the most important non-synonymous variant which varies among different background populations. Kurds, an ethnic population descended mainly from indigenous inhabitants of Zagros mountain survived for millennia, with nearly 40 million populations, are distributed in Iraq, Turkey, Iran and Syria. There are no studies on genetic variations of TLR4 in this population, particularly in Iraqi Kurdistan. The aim of this study is to find the percentage frequency of TLR4 Thr399Ile variant in Kurdish populations in Iraq, particularly in Sulaymaniyah province. The percentage of single nucleotide polymorphisms (SNPs) of the TLR4 gene was determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). The results showed that the heterozygous variant of TLR4 Thr399Ile is 7.1% (n=85) in Sulaymaniyah populations. However, no homozygous mutant variant was found; this suggests that it is either absent or seldom among Kurds in the region. This study emphasises the perceptiveness of the TLR SNP in Sulaymaniyah populations that recommends future study for linking this genetic variation with both infectious and immunological diseases, in addition to historical, anthropological and archaeological studies.

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“…[4][5][6][7] Predispozan faktörlerin aksine sigara ve dumansız tütün kullanımının RAS oluşumunu engellediği düşünülmektedir.…”

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Rekürrent aftöz stomatit oluşumunda sigara kullanımı ve nikotin bağımlılığının etkisi

Akarslan¹,

Peker²

2016

Acta Odontol Turc

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BULGULAR: 167 hasta (%33.2) RAS hikayesi olduğunu belirtti. Lezyon oluşma hikayesi ile cinsiyet ve eğitim seviyesi arasında anlamlı fark bulunmadı (p=0.100 ve p=0.906). Lezyon oluşumunu en fazla tetikleyen faktörün stres olduğu (%60.9), bunu nezle/grip'in takip ettiği (%47.5) bulgulandı. Hiç sigara kullanmamış hastalardaki RAS hikayesinin sigara içenlere ve içip bırakanlara göre anlamlı olarak daha yüksek olduğu saptandı (p=0.000). RAS hikayesi olan hastaların FNBT skor ortalamasının RAS hikayesi olmayan hastalarınkine göre daha yüksek olduğu belirlendi (p=0.011). SONUÇ:Hastaların yaklaşık üçte birinde RAS hikayesi olduğu ve lezyonların oluşumunu etkileyen faktörler arasında en fazla stresin bildirildiği saptandı. Sigara içmeyen bireylerde lezyon oluşum hikayesinin daha yüksek oranda rapor edildiği belirlendi. Sigara içen bireylerde nikotin bağımlılığının lezyon gelişiminde etkisi olduğu saptandı.

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TLR2,TLR4 and CD86 gene polymorphisms in recurrent aphthous stomatitis

Abstract: This is the first study to investigate the association of TLR and CD86 with RAS. We found a significant association between TLR4 rs10759931 polymorphism and RAS. Confirmatory studies in other populations and functional investigations are needed to determine the role of TLR4 in RAS.

Cited by 24 publications

References 31 publications

Oral mucosal injury caused by mammalian target of rapamycin inhibitors: emerging perspectives on pathobiology and impact on clinical practice

Oral mucosal injury caused by mammalian target of rapamycin inhibitors: emerging perspectives on pathobiology and impact on clinical practice

Genetic Polymorphism of Toll-Like Receptor 4 Thr399Ile Variant in Iraqi Kurdish Population: Sulaymaniyah Province

Rekürrent aftöz stomatit oluşumunda sigara kullanımı ve nikotin bağımlılığının etkisi

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