<i>Serenoa repens</i>for Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia: Current Evidence and Its Clinical Implications in Naturopathic Medicine

Ooi, Soo Liang; Pak, Sok Cheon

doi:10.1089/acm.2016.0302

Cited by 24 publications

(20 citation statements)

References 36 publications

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“…Equisetum arvense extract 5α-reductase inhibitor [44] Fenugreek oil Trigonella foenumgraecum oil Anti-inflammatory, antioxidant, antifungal, and antibacterial properties [45] Tall oil fatty acids Tall oil fatty acid β-Sitosterol component may be an effective 5-alpha reductase inhibitor [46] Green tea extract with 95% EGCG Camellia sinensis leaf extract Phytoconstituent epigallocatechin 3-gallate is a 5-α reductase inhibitor [47] Saw palmetto Serenoa serrulata Inhibits both isoforms of 5-α reductase, preventing conversion of testosterone to its active form, DHT, and also promotes hair follicle vascularization [48,49] Eclipta alba oil Eclipta alba (bhringraj oil)…”

Section: Horsetail Extractmentioning

confidence: 99%

A Multimodal Hair-Loss Treatment Strategy Using a New Topical Phytoactive Formulation: A Report of Five Cases

Umar

Carter

2021

Case Reports in Dermatological Medicine

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Introduction. Current approved medications for hair loss, such as topical minoxidil and oral finasteride, may have suboptimal efficacy or side effects precluding continued use in some patients. Thus, we report an evaluation of the efficacy, safety, and tolerability of a new topical botanical formulation -GASHEE containing over 12 phytoactive ingredients that affect multiple targets in the cascade of pathophysiologic events that cause hair loss. Five patients with various hair-loss conditions, including cases of previous treatment failures, are presented. Case Presentation. This is a case series of four women and one man with hair loss due to various causes, four of whom had failed minoxidil treatment for over a year. All patients used the topical treatment as a sole therapy for at least 3 months before the documentation of outcomes, which involved interval changes noted through each patient’s account, direct observation, and photography. Discussion. In all patients, we observed significant improvements in hair regrowth in the nape, crown, vertex, and temple areas after 3–15 months of treatment. All patients were highly satisfied with their results and reported no adverse events. Although the use of botanicals in the treatment of hair loss is in an infant stage, the new formulation used in this study demonstrated a good efficacy related to hair growth, warranting further evaluation.

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Section: Horsetail Extractmentioning

confidence: 99%

A Multimodal Hair-Loss Treatment Strategy Using a New Topical Phytoactive Formulation: A Report of Five Cases

Umar

Carter

2021

Case Reports in Dermatological Medicine

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“…On the contrary, some authors described that Serenoa repens extracts have not shown more effectiveness than placebo in the treatment of BPH [24][25][26]. However, more recent data favor the use of Serenoa repens extracts in milder BPH cases with promising results [27].…”

Section: Discussionmentioning

confidence: 99%

Effects of Serenoa repens Alcohol Extract on Benign Prostate Hyperplasia

Saidi

Stavridis

Stankov

et al. 2017

Prilozi

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An increasing tendency has recently emerged for the use of phytotherapeutic agents as alternative to commercial pharmacological agents for the treatment of benign prostate hyperplasia (BPH). The purpose of this study is to evaluate the effects of Serenoa repens alcohol extract treatment on BPH patients' symptoms and major parameters during one-year follow-up. The study was performed on 70 men aged 40 -79 years (mean 60.58) with symptomatic BPH that were divided into a group of 40 patients treated with Serenoa repens extract (SRT) and a control group of 30 patients that received no treatment and were observed only. The following parameters were determined at the time of diagnosis (baseline), and after 6 and 12 months: prostate size, serum prostate-specific antigen (PSA) and uroflowmetry parameters including maximum flow rate (MFR), average flow rate (AFR) and post-voiding residual volume (PVRV). In addition, the relevant patient symptoms were evaluated using the International Prostate Symptom Score (IPSS) system. The patients in the SRT group showed a statistically significant increment of the average MFR and AFR values and reduction of PV relative to the control group (p<0.05). The significant differences between the proportion of patients with prostate volume >40 ml in the SRE treated group vs. control group was observed (p<0.05). The mean IPSS score was highly significantly reduced in the SRT group (p<0.01). The mild improvements of the urine flow, prostate size and IPSS score during 12 months treatment with the Serenoa repens extract indicate possible efficiency of this phytotherapeutic agent in patients with BPH.

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“…S. repens'in aktif bileşikleri ağırlıklı olarak serbest yağ asitleri (laurik asit, oleik asit, miristik asit, palmitik asit ve linoleik asit) ve fitosterollerdir (betasitosterol, kampesterol ve stigmasterol) [45]. [6].…”

Section: Bph'de Kullanılan Fitoterapötikler Veunclassified

Effects of Phytoterapeutics on Benign Prostate Hyperplasia

Çalişkan¹,

Durbilmez²,

Memiş³

2019

Ankara Universitesi Eczacilik Fakultesi Dergisi

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Amaç: İyi huylu prostat büyümesi (Benign Prostat Hiperplazisi=BPH), elli yaş üstü erkeklerin ortalama üçte birinde görülen hem idrar depolama, boşaltma ve boşaltma sonrası semptomlara yol açan, hem de olguların yaşam kalitesini bozan bir durumdur. BPH'ye bağlı alt üriner sistem hastalıklarının tedavisinde fitoterapötikler uzun zamandan beri klinik uygulamalarda yer almaktadır. Bu çalışmanın amacı BPH tedavisinde en sık kullanılan fitoterapötikler olan Cucurbita pepo, Epilobium sp., Hypoxis rooperi, Lycopersicon esculentum Mill., Pinus pinaster Aiton, Pygeum africanum, Roystonea regia (Kunth) O.F. Cook, Secale cereale, Serenoa repens, Urtica dioica'nın etkinlikleri ve yapılan önemli klinik çalışmaları derlemektir. Sonuç ve Tartışma: Kanıta dayalı tıp zemininde BPH'ye yönelik alt üriner sistem hastalıklarının tedavisinde fitoterapötiklerin birçok semptomda düzelme sağladığı söylenmekle birlikte çalışmalar daha fazla plasebo kontrollü, çift-kör randomize çalışmalara ihtiyaç duyulduğunu göstermektedir.

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Serenoa repensfor Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia: Current Evidence and Its Clinical Implications in Naturopathic Medicine

Abstract: The totality of evidence includes favorable patients' response from clinical experience, impact of placebo effect, early positive studies, subjective nature of symptom reporting, pharmacological properties of S. repens, and potential synergistic effects when combined with other therapies.

Cited by 24 publications

References 36 publications

A Multimodal Hair-Loss Treatment Strategy Using a New Topical Phytoactive Formulation: A Report of Five Cases

A Multimodal Hair-Loss Treatment Strategy Using a New Topical Phytoactive Formulation: A Report of Five Cases

Effects of Serenoa repens Alcohol Extract on Benign Prostate Hyperplasia

Effects of Phytoterapeutics on Benign Prostate Hyperplasia

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