<i>Serratia marcescens</i>endogenous endophthalmitis in an immunocompetent host

Memon, Muhammad; Raman, Vasant

doi:10.1136/bcr-2015-209887

Cited by 6 publications

(2 citation statements)

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“…In our patient, the stomach, lung, and eye were involved. Serratia is a rare cause of endogenous endophthalmitis, accounting for 4% of cases [ 9 , 10 ]. In the last 5 years, 6 cases of Serratia endogenous endophthalmitis in adults have been reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

“…IV drug use was reported in 2 patients who described “needle licking” behavior and poor dental hygiene was the likely source [ 4 ]. Other patients had chronic medical illnesses that resulted in use of hemodialysis, ventilator dependency, or chronic urinary catheters, which suggests that chronic comorbidities are risk factors [ 10 – 13 ]. The most common clinical presentation is a decrease in vision, as in our patient.…”

Section: Discussionmentioning

confidence: 99%

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Serratia marcescens Infection-Associated Loss of Vision: A Case Report in a Patient with a History of Intravenous Drug Use

et al. 2021

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Patient: Male, 53-year-old Final Diagnosis: Disseminated Serratia marcescens infection Symptoms: Loss of vision Medication: — Clinical Procedure: Enucleation of the eye • tricuspid valve replacement Specialty: Infectious Diseases Objective: Rare disease Background: Serratia marcescens infections have historic association with injection drug use. The present report is about a 53-year-old man with a history of intravenous (IV) drug use who presented with acute loss of vision due to endophthalmitis associated with disseminated S. marcescens infection. Case Report: A 53-year-old man with a history of active illicit IV drug use presented with a chief complaint of loss of vision in his left eye for 5 days. He also reported having a fever, chills, and shortness of breath. While in the Emergency Department, he became hypotensive and hypoxic. He needed to be intubated and was started on vasopressor support. An ophthalmological examination was suspicious for endophthalmitis. The patient underwent a vitreous tap with injection of intravitreal antibiotics on the day of admission. An echocardiogram showed severe tricuspid endocarditis requiring valve replacement. He also was found to have a left lung/pleural abscess, which was surgically drained. Later, a left eye vitrectomy was performed and the intravitreal antibiotics were repeated; the treatment was unsuccessful and enucleation eventually was required. In addition, the patient had gastric bleeding and underwent esophagogastroduodenoscopy, which showed ischemic stomach ulcers suggestive of septic emboli. Cultures of the patient’s blood, tricuspid valve, lung abscess, and vitreous fluid revealed S. marcescens . He was treated long term with a 2-drug antibiotic regimen and discharged in stable condition. Conclusions: We have presented a rare case of acute loss of vision due to endophthalmitis in a patient with a history of IV drug use, which was associated with disseminated infection with the Gram-negative saprophyte S. marcescens .

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Serratia marcescens Infection-Associated Loss of Vision: A Case Report in a Patient with a History of Intravenous Drug Use

et al. 2021

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Neuroimaging of ocular involvement in patients with sickle cell disease and review of the literature

et al. 2017

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Endophthalmitis is a rare cause of ocular infection that can be associated with immunocompromising conditions and, more rarely, with sickle cell disease. In this case report and review of the literature, we present a case of a young male with sickle cell disease who presented with rapidly progressive ocular pain, edema, erythema, and decreased visual acuity. The key radiological findings to suggest endophthalmitis were demonstrated using computed tomography and magnetic resonance imaging.

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Antimicrobial Treatment of Serratia marcescens Invasive Infections: Systematic Review

Zarić

Sekulic

et al. 2023

Antibiotics

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Background: Serratia marcescens (SM) is a Gram-negative pathogen discovered by Italian pharmacist, Bizio, in 1819. According to the literature, S. marcescens is resistant to a wide range of antibiotics, including penicillin, cephalosporin, tetracycline, macrolide, nitrofurantoin, and colistin. We conducted a systematic review of published reports, determined what invasive infections could cause SM, and established the most appropriate antibiotic therapy. Methods: We registered this systematic review on the PROSPERO registry of systematic reviews–meta-analyses before we started our research (registration number CRD42022323159). The online searches of published studies were implemented via MEDLINE, the Cochrane Central Register of Controlled Trials, EBSCO, Scopus, Google Scholar, SCIndex, and the registry of clinical studies of human participants (ClinicalTrials.gov). Results: Our study included 32 published articles (9 case series and 23 case reports). There were 57 individual cases, respectively. The oldest patient was 97 years and the youngest patient was a newborn. S. marcescens was, in most cases, isolated from blood followed by urine and cerebrospinal fluid. In most cases, sensitivity was tested to cotrimoxazole (from 27 isolates, 10 showed resistance) followed by gentamicin (from 26 isolates, 3 showed resistance) as well as amikacin (from 21 isolates, none showed resistance). Patients died from an infection in 21 cases (31%). Conclusions: Treatment of SM infections should include carbapenems or aminoglycosides in combination with third-generation (and eventually fourth-generation) cephalosporin. Cotrimoxazole should be considered in cases of uncomplicated urinary infections.

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Serratia marcescensendogenous endophthalmitis in an immunocompetent host

Cited by 6 publications

References 5 publications

Serratia marcescens Infection-Associated Loss of Vision: A Case Report in a Patient with a History of Intravenous Drug Use

Serratia marcescens Infection-Associated Loss of Vision: A Case Report in a Patient with a History of Intravenous Drug Use

Neuroimaging of ocular involvement in patients with sickle cell disease and review of the literature

Antimicrobial Treatment of Serratia marcescens Invasive Infections: Systematic Review

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