<i>Solanum trilobatum</i>in the management of atopy: Through inhibition of mast cell degranulation and moderation of release of interleukins

Ranjith, M. S.; Ranjitsingh, A. J. A.; Vijayalaksmi, G. S.; Kumari, Deepa; Babu, K. K. Raja; Sidhu, Harcharan Singh

doi:10.4103/0974-8490.60581

Cited by 13 publications

(6 citation statements)

References 11 publications

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“…Similar studies with Anti-inflammatory and antimicrobial properties of aqueous and organic solvent extracts of S. trilobatum exists with positive results. 9 Correspondingly, antifungal mechanism of S. trilobatum against Aspergillus brasiliensis-MTCC1344 and Aspergillus fumigatus-MTCC 343 was demonstrated to be good. 10 Reports with Solanum trilobatum cation sensitive heat-stable antifungal protein from the leaves with a molecular mass of 31 KDa showing stability for a wide range of pH between 5 and 8.5 has been proved to delay the hyphal extension making the fungi static.…”

Section: Discussionmentioning

confidence: 92%

A Study of Folklore Antifungal Medicinal Herbs among the Tribal Groups of Western Ghats, Coimbatore, Tamil Nadu

Rangasamy,

Jeyarajan,

Gunasekaran

2023

Int J. Pharm. Investigation

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Background: The present study has been carried out to explore antifungal property of folklore medicinal herbs Solanum trilobatum, Spathodea campanulata, Syzygium jambos and Tylophora indica prevalent among the tribal communal in the Western Ghats of Coimbatore district. Materials and Methods:The aqueous and organic leaf extracts obtained by cold maceration method was confirmed for its antifungal activity against Aspergillus flavus and Aspergillus fumigatus by agar plate dilution method. Results: The methanolic extracts of S. trilobatum, S. jambos and T. indica exhibited substantial (p<0.001) fungal growth inhibition against A. flavus with IC 50 values 40.63, 94.56 and 84.52 µg/mL respectively. The ethanolic extracts of S. trilobatum, S. campanulata, S. jambos and T. indica also revealed (p<0.01) inhibitory activity against A. flavus with IC 50 values ranging between 102.34-146.79 µg/mL, whereas the S. campanulata methanolic and chloroform fractions of S. jambos influenced mycelial inhibition against A. flavus with a IC 50 values at 147.92 and 111.08 µg/mL respectively. Furthermore, the methanolic extracts of S. campanulata exposed highly significant antifungal activity against A. fumigatus, (p<0.001) with IC 50 value at 95.3 µg/mL. Analogous antifungal significances were also observed among methanolic extracts of S. jambos and T. indica against A. fumigatus with IC 50 values at 131.52 and 114.51 µg/mL respectively. The other extracts were not up to the pronounceable level of fungal growth control against the two fungal strains used in the assay. Conclusion: The alcoholic leaf extracts of selected plants were more active against tested fungal strains when compared to the chloroform and aqueous extracts. Further surveys and findings have to be fixed to recognize the antifungal metabolites present in the chosen herbs.

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Section: Discussionmentioning

confidence: 92%

A Study of Folklore Antifungal Medicinal Herbs among the Tribal Groups of Western Ghats, Coimbatore, Tamil Nadu

Rangasamy,

Jeyarajan,

Gunasekaran

2023

Int J. Pharm. Investigation

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“…(Benny et al, 2004;Kripa et al, 2011;Sunila & Kuttan, 2004). We have established the immunoprotective/immunomodulating effect can be achieved using polyherbal formulation earlier in our studies (Ranjith et al, 2010). Polyherbal formulation increases the phagocytosis index to several times over control when tested against murine phagocytes in vitro (Ranjith et al, 2008).…”

Section: Resultsmentioning

confidence: 97%

An Overview of Management of URTI and a Novel Approach Towards RSV Infection

Krishnamoorthy¹,

Ranjith²,

Gokulshankar³

et al. 2012

Respiratory Diseases

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“…[ 19 20 ] Furthermore, some plant resources which possess antioxidant activity demonstrate a potential for an effective management of atopic disease. [ 21 22 ] Therefore, it is assumed that the inhibitory effect of natsumikan on chronic allergic dermatitis in our mouse model may be mediated, at least in part, by its antioxidative properties, but further studies are required to confirm this.…”

Section: Discussionmentioning

confidence: 99%

Extract from peel of Citrus natsudaidai alleviates experimental chronic allergic dermatitis in mice

Nakayama¹,

Yamaura²,

Shimada³

et al. 2011

Phcog Res

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Background:Citrus natsudaidai (natsumikan) is a typical citrus fruit containing several antioxidative nutrients which are found in higher concentration in the peel than in the pulp of the fruit. In this study, we examined whether extract from immature natsumikan peel prevents development of chronic allergic dermatitis in mice.Materials and Methods:Chronic allergic dermatitis was induced by repeated application of 2, 4, 6-trinitro-1-chlorobenzene in BALB/c mice and natsumikan was administrated orally for 30 days. Ear swelling and dermatitis score were measured after each challenge. The level of derivative-reactive oxygen metabolites (d-ROM) in serum was measured on day 30.Results:Treatment of natsumikan significantly attenuated the increase in ear swelling and improved dermatitis scores. In addition, increases in serum d-ROM were attenuated by a treatment of natsumikan. Although the routine treatment with dexamethasone resulted in a clear and significant reduction in body weight, natsumikan treatment did not have such effects.Conclusion:Immature natsumikan peel is beneficial for the treatment of chronic allergic dermatitis.

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Solanum trilobatumin the management of atopy: Through inhibition of mast cell degranulation and moderation of release of interleukins

Cited by 13 publications

References 11 publications

A Study of Folklore Antifungal Medicinal Herbs among the Tribal Groups of Western Ghats, Coimbatore, Tamil Nadu

A Study of Folklore Antifungal Medicinal Herbs among the Tribal Groups of Western Ghats, Coimbatore, Tamil Nadu

An Overview of Management of URTI and a Novel Approach Towards RSV Infection

Extract from peel of Citrus natsudaidai alleviates experimental chronic allergic dermatitis in mice

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