<i>SOX4</i> as biomarker in hepatitis B virus-associated hepatocellular carcinoma

Huang, Jianlv; Wang, Xiangkun; Liao, Xiwen; Han, Chuangye; Yu, Tingdong; Huang, Ketuan; Yang, Chengkun; Liu, Xiaoguang; Liu, Yu; Zhu, Guangzhi; Su, Hao; Han, Quanfa; Liu, Zheng-Qian; Zhou, Xin; Liu, Junqi; Ye, Xinping; Peng, Tao

doi:10.7150/jca.46579

Cited by 12 publications

(9 citation statements)

References 59 publications

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“…We also discovered that miR-381 might suppress SOX4 expression in renal cell CSCs for several potential genes. SOX4 has been demonstrated to be dysregulated in several malignancies [ 34 ]. Recent studies showed an important role for SOX4 in epithelial–mesenchymal transition (EMT) [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

miRNA-381 regulates renal cancer stem cell properties and sunitinib resistance via targeting SOX4

Lu,

Gao,

et al. 2023

Biochemistry and Biophysics Reports

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Section: Discussionmentioning

confidence: 99%

miRNA-381 regulates renal cancer stem cell properties and sunitinib resistance via targeting SOX4

Lu,

Gao,

et al. 2023

Biochemistry and Biophysics Reports

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“…Many SOX members show significant clinical implications in HCC. For instance, the overexpressed SOX4 or SOX12 is positively associated with the poor survival of HCC, while low SOX6 or SOX7 expression predicts shorter disease-free survival and overall survival, which provide potential diagnostic and prognostic markers for HCC [ 56 , 57 , 58 , 59 , 79 , 87 , 127 ]. In addition to serving as the predictors of diagnosis and prognosis, many SOX members are also potential therapeutic targets for HCC.…”

Section: Discussion and Outlookmentioning

confidence: 99%

“…Convincing evidence has shown that SOX4, as the direct transcription target of Smad2 and Smad3 downstream of TGFβ, plays a master role in TGFβ-induced EMT, invasion, and metastasis of tumors [ 51 , 52 ]. In HCC, the SOX4 expression is remarkably increased in tumor tissues, especially in metastatic and recurrent HCC samples [ 53 , 54 , 55 , 56 , 57 , 58 , 59 ]. The overexpressed SOX4 is positively associated with higher intratumoral microvessel density, distant metastasis, and poor survival of HCC cases, which provides a potential diagnostic and prognostic marker for HCC [ 56 , 57 , 58 , 59 ].…”

Section: Sox Transcription Factors In Hepatocellular Carcinomamentioning

confidence: 99%

“…In HCC, the SOX4 expression is remarkably increased in tumor tissues, especially in metastatic and recurrent HCC samples [ 53 , 54 , 55 , 56 , 57 , 58 , 59 ]. The overexpressed SOX4 is positively associated with higher intratumoral microvessel density, distant metastasis, and poor survival of HCC cases, which provides a potential diagnostic and prognostic marker for HCC [ 56 , 57 , 58 , 59 ]. As a crucial metastasis-associated regulator, SOX4 induces the chemotaxis of human umbilical vein endothelial cells, angiogenesis, and tumor growth in HCC by activating CXCL12, therefore facilitating HCC metastasis [ 58 ].…”

Section: Sox Transcription Factors In Hepatocellular Carcinomamentioning

confidence: 99%

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Advance of SOX Transcription Factors in Hepatocellular Carcinoma: From Role, Tumor Immune Relevance to Targeted Therapy

Luo

Xie

et al. 2022

Cancers

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Sex determining region Y (SRY)-related high-mobility group (HMG) box (SOX) factors belong to an evolutionarily conserved family of transcription factors that play essential roles in cell fate decisions involving numerous developmental processes. In recent years, the significance of SOX factors in the initiation and progression of cancers has been gradually revealed, and they act as potential therapeutic targets for cancer. However, the research involving SOX factors is still preliminary, given that their effects in some leading-edge fields such as tumor immune microenvironment (TIME) remain obscure. More importantly, as a class of ‘undruggable’ molecules, targeting SOX factors still face considerable challenges in achieving clinical translation. Here, we mainly focus on the roles and regulatory mechanisms of SOX family members in hepatocellular carcinoma (HCC), one of the fatal human health burdens worldwide. We then detail the role of SOX members in remodeling TIME and analyze the association between SOX members and immune components in HCC for the first time. In addition, we emphasize several alternative strategies involved in the translational advances of SOX members in cancer. Finally, we discuss the alternative strategies of targeting SOX family for cancer and propose the opportunities and challenges they face based on the current accumulated studies and our understanding.

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“…Although there are several approaches to address this limitation, there is still an urgent need for effective, noninvasive, and highly sensitive and specific biomarkers to accurately detect early HCC [12]. In recent years, more and more studies have found that many genes can be used as biomarkers for the early screening and diagnosis of liver cancer, such as NEK2, SOX4, CTHRC1, SLC25A11, and Laminin-γ2 [13][14][15][16][17]. In addition, there are many molecules that can be used as drug targets for HCC, providing new ideas for drug treatment of HCC [18,19].…”

Section: Introductionmentioning

confidence: 99%

Overexpression of Aurora Kinase B Is Correlated with Diagnosis and Poor Prognosis in Hepatocellular Carcinoma

Zhang,

Ma,

et al. 2024

IJMS

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Aurora kinase B (AURKB) overexpression promotes tumor initiation and development by participating in the cell cycle. In this study, we focused on the mechanism of AURKB in hepatocellular carcinoma (HCC) progression and on AURKB’s value as a diagnostic and prognostic biomarker in HCC. We used data from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) to analyze AURKB expression in HCC. We found that the expression levels of AURKB in HCC samples were higher than those in the corresponding control group. R packages were used to analyze RNA sequencing data to identify AURKB-related differentially expressed genes (DEGs), and these genes were found to be significantly enriched during the cell cycle. The biological function of AURKB was verified, and the results showed that cell proliferation was slowed down and cells were arrested in the G2/M phase when AURKB was knocked down. AURKB overexpression resulted in significant differences in clinical symptoms, such as the clinical T stage and pathological stage. Kaplan–Meier survival analysis, Cox regression analysis, and Receiver Operating Characteristic (ROC) curve analysis suggested that AURKB overexpression has good diagnostic and prognostic potential in HCC. Therefore, AURKB may be used as a potential target for the diagnosis and cure of HCC.

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SOX4 as biomarker in hepatitis B virus-associated hepatocellular carcinoma

Cited by 12 publications

References 59 publications

miRNA-381 regulates renal cancer stem cell properties and sunitinib resistance via targeting SOX4

miRNA-381 regulates renal cancer stem cell properties and sunitinib resistance via targeting SOX4

Advance of SOX Transcription Factors in Hepatocellular Carcinoma: From Role, Tumor Immune Relevance to Targeted Therapy

Overexpression of Aurora Kinase B Is Correlated with Diagnosis and Poor Prognosis in Hepatocellular Carcinoma

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