2020
DOI: 10.1101/2020.11.06.371740
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SPHERIOUSLY?The challenges of estimating spherical pore size non-invasively in the human brain from diffusion MRI

Abstract: The Soma and Neurite Density Imaging (SANDI) three-compartment model was recently proposed to disentangle cylindrical and spherical geometries, attributed to neurite and soma compartments, respectively, in brain tissue. The approach could also enable estimation of microstructure parameters such as the apparent size (radius) of the soma. There are some recent advances in diffusion-weighted MRI signal encoding and analysis (including the use of multiple so-called ‘b-tensor’ encodings and analysing the signal in … Show more

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“…Moreover, the precise structural measurements of the manufactured phantom may be not fully known, defeating the purpose of using such phantoms. Numerical phantoms are of particular interest in this context and have become the standard de facto for evaluating novel DW-MRI signal processing methods [7,21,4,14,1,13,6]. The realism of phantoms is a fundamental aspect.…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, the precise structural measurements of the manufactured phantom may be not fully known, defeating the purpose of using such phantoms. Numerical phantoms are of particular interest in this context and have become the standard de facto for evaluating novel DW-MRI signal processing methods [7,21,4,14,1,13,6]. The realism of phantoms is a fundamental aspect.…”
Section: Introductionmentioning
confidence: 99%