<i>Spirulina platensis</i>ameliorates arsenic-mediated uterine damage and ovarian steroidogenic disorder

Khatun, Shamima; Maity, Moulima; Perveen, Hasina; Dash, Moumita; Chattopadhyay, Sandip

doi:10.1139/facets-2017-0099

Cited by 16 publications

(6 citation statements)

References 61 publications

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“…In addition, Bashandy et al (2016) revealed that S. platensis recovered the decreased testosterone level in Sodium Arsenite toxicity. In addition, our result concerning oestrogen was in harmony with Khatun et al (2018), in which they confirmed that S. platensis recovered the gonadotropins and estradiol low signalling induced by arsenic.…”

Section: Discussionsupporting

confidence: 91%

Arthrospira platensisnanoparticles defeat against diabetes‐induced testicular injury in rat targeting, oxidative, apoptotic, and steroidogenesis pathways

et al. 2022

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Varieties of studies have been used to investigate the health benefits of Spirulina (Arthrospira platensis); however, more research is needed to examine if its nano form may be utilized to treat or prevent several chronic diseases. So, we designed this study to explore the effect and the cellular intracellular mechanisms by which Arthrospira platensis Nanoparticles (NSP) alleviates the testicular injury induced by diabetes in male Wistar rats. Eighty Wistar male rats (n = 80) were randomly allocated into eight groups. Group 1 is untreated rats (control), Group 2 including STZinduced diabetic rats with 65 mg/kg body weight STZ (STZ-diabetic), Group 3-5: including diabetic rats treated with NSP1, NSP2, and NSP3 at 0.25, 0.5, and 1 mg/kg body weight, respectively, once daily orally by the aid of gastric gavage for 12 consecutive weeks and groups 6-8 include normal rats received NSP (0.25, 0.5, and 1 mg/kg body weight once daily orally. The identical volume of normal saline was injected into both control and diabetic rats. After 12 weeks of diabetes induction, the rats were killed. According to our findings, NSP administration to diabetic rats enhances the total body weight and the weight of testes and accessory glands; in addition, NSP significantly reduced nitric oxide and malondialdehyde in testicular tissue improved sperm parameters. Intriguingly, it raises testicular GSH and SOD activity by a significant amount (p < 0.05). As well, Oral administration of NSP to diabetic rats resulted in a decrease in the blood glucose levels, HA1C, induced in the diabetic group, which overcame the diabetic complications NSP caused down-regulation of apoptotic genes with upregulation of BCL-2 mRNA expression (p < 0.05) and prominent up-regulation of steroidogenesis genes expression level in testes in comparison to the diabetic rats which resulted in improving the decreased levels of testosterone hormone, FSH, and LH induced by diabetes. In the same way, our histopathological findings support our biochemical and molecular findings; in conclusion, NSP exerted a protective effect against reproductive dysfunction induced by diabetes not only through its high antioxidant and hypoglycemic action but also through its down-regulation of Apoptotic genes and up-regulation of steroidogenesis regulatory genes expression level in diabetic testes.

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Section: Discussionsupporting

confidence: 91%

Arthrospira platensisnanoparticles defeat against diabetes‐induced testicular injury in rat targeting, oxidative, apoptotic, and steroidogenesis pathways

et al. 2022

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“…Increased uterine MDA and CD levels in arsenic fed rats (Table 2) directed an increase in lipid peroxidation. The inhibitory effects of spirulina on lipid peroxidation were in conformity with the previous result 19 . Other investigators explored the therapeutic effects of spirulina on arsenic-induced male reproductive toxicity 20 .…”

Section: Discussionsupporting

confidence: 92%

Combined Dietary Action of Spirulina and Probiotics Mitigates Female Reproductive Ailments in Arsenicated Rats

Khatun¹,

Chatterjee²,

Chattopadhyay³

2019

J Pure Appl Microbiol

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Heavy metals contaminations in food and water are increased due to the environmental pollution. Managing arsenic toxicosis by dietary therapy is yet to be explored, although the conventional therapeutic strategy emphasizes the invasive chelating therapy. In this present study we elucidated the ameliorative effect of Spirulina and probiotics against arsenic-mediated female gonadal injury. The treatment was continued for 8 days (2 estrus cycles) on rats with sodium arsenite (1.0 mg/ 100g body weight) orally, but spirulina (40 mg/100g body weight) and commercially available probiotics mixture (2 mg/ 100g body weight) were added in rat chow, fresh daily. Uterine and ovarian tissue experienced a significant impairment of antioxidant status, while a pronounced ovarian follicular degeneration was apparent from the increased number of follicular atresia in arsenic treated rats. All these deleterious effects of sodium arsenite were diminished significantly by spirulina and probiotics in arsenic fed rat. Moreover, an increase in the serum levels of of homocysteine (Hcy) in association with reduced serum levels of vitamin B 12 and folic acid were mitigated in arsenic fed rats following spirulina and probiotics dietary co-administration. However, the outcome of this study may indicate that spirulina and probiotics may be incorporated in the meal as nutraceuticals in limiting arsenic-mediated health hazards.

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“…Polyphenol-rich apple ( Malus domestica ) peel extract attenuates arsenic trioxide-induced cardiotoxicity in h9c2 cells via its antioxidant activity [ 116 ]. Extract of Spirulina ( Cyanobacteria ) can remove As from isolated liver tissues [ 117 ]. Flavonolignan, silibinin, present in Silybum marianum , has positive impacts in As-exposed rats, which are attributed to its antioxidant potential [ 118 ].…”

Section: Approaches To the Treatment Of Diseases Caused By Toxic Effe...mentioning

confidence: 99%

Natural Dietary Compounds in the Treatment of Arsenic Toxicity

et al. 2022

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Chronic exposure to arsenic (As) compounds leads to its accumulation in the body, with skin lesions and cancer being the most typical outcomes. Treating As-induced diseases continues to be challenging as there is no specific, safe, and efficacious therapeutic management. Therapeutic and preventive measures available to combat As toxicity refer to chelation therapy, antioxidant therapy, and the intake of natural dietary compounds. Although chelation therapy is the most commonly used method for detoxifying As, it has several side effects resulting in various toxicities such as hepatotoxicity, neurotoxicity, and other adverse consequences. Drugs of plant origin and natural dietary compounds show efficient and progressive relief from As-mediated toxicity without any particular side effects. These natural compounds have also been found to aid the elimination of As from the body and, therefore, can be more effective than conventional therapeutic agents in ameliorating As toxicity. This review provides an overview of the recently updated knowledge on treating As poisoning through natural dietary compounds. This updated information may serve as a basis for defining novel prophylactic and therapeutic formulations.

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Spirulina platensisameliorates arsenic-mediated uterine damage and ovarian steroidogenic disorder

Cited by 16 publications

References 61 publications

Arthrospira platensisnanoparticles defeat against diabetes‐induced testicular injury in rat targeting, oxidative, apoptotic, and steroidogenesis pathways

Arthrospira platensisnanoparticles defeat against diabetes‐induced testicular injury in rat targeting, oxidative, apoptotic, and steroidogenesis pathways

Combined Dietary Action of Spirulina and Probiotics Mitigates Female Reproductive Ailments in Arsenicated Rats

Natural Dietary Compounds in the Treatment of Arsenic Toxicity

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