<i>Staphylococcus argenteus</i>
            Infections, Brazil

Balzan, Lisiane da Luz Rocha; Rossato, Adriana Medianeira; Riche, Cezar Vinícius Würdig; Cantarelli, Vlademir Vicente; d’Azevedo, Pedro Alves; Andrade-Lima, Aluísio; Rodrigues, Beatriz Quental; Silva, Ivan Leonardo Avelino França e; Dias, Cícero Armídio Gomes; Sampaio, Julliane Messias Cordeiro

doi:10.1128/spectrum.01179-22

Cited by 3 publications

(4 citation statements)

References 10 publications

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“…Both ST-2250 and ST-1223 were confirmed as the predominant genotypes in Hong Kong. Additionally, the ST-2250 strain was also identified in other Asian cities, where it caused various forms of infections [6,8,20,21,24]. The ST-1223 is another emerging genotype that has associations with human infections.…”

Section: Discussionmentioning

confidence: 99%

“…It was later proposed to become a new species in 2015 [4]. An increasing number of cases have been reported in different countries across Oceania, Africa, America, Asia, and Europe between 2015-2023 [5][6][7][8][9][10]. Southeast Asia, the Amazon, and remote regions in Australia have shown a high prevalence of S. argenteus [11].…”

Section: Introductionmentioning

confidence: 99%

“…According to the PubMLST database, over 60 MLST types of S. argenteus have been reported in different geographical regions, with the ST-2250 variant being most frequently reported genotype [11]. Other MLSTs, including ST-1223, ST-1850, ST-2198, ST-2793, ST-2854, and ST-3261, have also been associated with human infections worldwide [8,9,12,21,31,[35][36][37][38][39][40]. Different MLST genotypes carry distinct virulence genes and antimicrobial resistance (AMR) genes [40].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and Characteristics of Invasive Staphylococcus argenteus among Patients with Bacteremia in Hong Kong

Chen,

Leung,

Wong

et al. 2023

Microorganisms

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Staphylococcus argenteus is a novel Staphylococcus species derived from Staphylococcus aureus. Information on the prevalence and genetic characteristics of invasive S. argenteus in Asia is limited. In this study, 275 invasive S. aureus complex strains were retrieved from blood culture specimens in Hong Kong and re-analyzed using MALDI-TOF mass spectrometry and an in-house multiplex real-time PCR for S. argenteus. The prevalence of invasive S. argenteus in Hong Kong was found to be 4.0% (11/275). These strains were primarily susceptible to commonly used antibiotics, except penicillin. Whole-genome sequencing revealed the circulation of three S. argenteus genotypes (ST-2250, ST-1223, and ST-2854) in Hong Kong, with ST-2250 and ST-1223 being the predominant genotypes. The local ST-2250 and ST-1223 strains showed close phylogenetic relationships with isolates from mainland China. Antimicrobial-resistant genes (fosB, tet-38, mepA, blaI, blaZ) could be found in nearly all local S. argenteus strains. The ST-1223 and ST-2250 genotypes carried multiple staphylococcal enterotoxin genes that could cause food poisoning and toxic shock syndrome. The CRISPR/Cas locus was observed only in the ST-2250 strains. This study provides the first report on the molecular epidemiology of invasive S. argenteus in Hong Kong, and further analysis is needed to understand its transmission reservoir.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence and Characteristics of Invasive Staphylococcus argenteus among Patients with Bacteremia in Hong Kong

Chen,

Leung,

Wong

et al. 2023

Microorganisms

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“…[3] Subsequently, several studies reported sporadic cases of infections caused by S argenteus in Asia, Oceania, the Pacific Islands, Latin America, Europe, and Africa. [3–6] Here, we describe a fatal case of bacteremia caused by S argenteus isolated from bloodstream of a comatose patient.…”

Section: Introductionmentioning

confidence: 99%

Fatal bacteremia caused by Staphylococcus argenteus: A case report

Zhan,

Tang,

Zhang

et al. 2023

Medicine

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Rationale: Staphylococcus argenteus (S argenteus) is a novel and emerging species that is part of the Staphylococcus aureus (S aureus) complex. Fatal cases of bloodstream infection caused by S argenteus are rarely reported and should be considered in medical practice. Patient concerns: A 44-year-old male was admitted to our hospital with reduced appetite, high fever and unconsciousness. Laboratory tests indicated infection, muscle damage, and alkalosis in the patient. Brain computed tomography (CT) demonstrated small hematoma in left frontal lobe with peripheral cerebral edema. Chest CT demonstrating chronic bronchitis, emphysema, and bullae in the right lung. Blood culture was collected on the first day of hospitalization for microbial culture and pathological examination. Diagnosis: The isolate from blood culture was identified as S argenteus by MALDI-TOF MS after the patient death. Interventions: The patient was subjected to empirical antibiotic treatment with piperacillin/tazobactam. Outcomes: After 48 hours of hospitalization, the patient died after ineffective rescue. Lessons: The patient had long-term heavy drinking and smoking as well as chronic malnutrition, which may account for his immune deficiency. The immunocompromised people are more vulnerable to infection by S argenteus and then develop bacteremia. The use of piperacillin/tazobactam may have contributed to the patient death.

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Sex differences and testosterone interfere with the structure of the gut microbiota through the bile acid signaling pathway

Duan,

Nie,

Xie

et al. 2024

Front. Microbiol.

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BackgroundThe gut microbiome has a significant impact on human wellness, contributing to the emergence and progression of a range of health issues including inflammatory and autoimmune conditions, metabolic disorders, cardiovascular problems, and psychiatric disorders. Notably, clinical observations have revealed that these illnesses can display differences in incidence and presentation between genders. The present study aimed to evaluate whether the composition of gut microbiota is associated with sex-specific differences and to elucidate the mechanism.Methods16S-rRNA-sequencing technology, hormone analysis, gut microbiota transplantation, gonadectomy, and hormone treatment were employed to investigate the correlation between the gut microbiome and sex or sex hormones. Meanwhile, genes and proteins involved bile acid signaling pathway were analyzed both in the liver and ileum tissues.ResultsThe composition and diversity of the microbiota from the jejunum and feces and the level of sex hormones in the serum differed between the sexes in young and middle-aged Sprague Dawley (SD) rats. However, no similar phenomenon was found in geriatric rats. Interestingly, whether in young, middle-aged, or old rats, the composition of the microbiota and bacterial diversity differed between the jejunum and feces in rats. Gut microbiota transplantation, gonadectomy, and hormone replacement also suggested that hormones, particularly testosterone (T), influenced the composition of the gut microbiota in rats. Meanwhile, the mRNA and protein level of genes involved bile acid signaling pathway (specifically SHP, FXR, CYP7A1, and ASBT) exhibited gender-specific differences, and T may play a significant role in mediating the expression of this pathway.ConclusionSex-specific differences in the structure of the gut microbiota are mediated by T through the bile acid signaling pathway, pointing to potential targets for disease prevention and management techniques by indicating that sex differences and T levels may alter the composition of the gut microbiota via the bile acid signaling pathway.

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Staphylococcus argenteus Infections, Brazil

Cited by 3 publications

References 10 publications

Prevalence and Characteristics of Invasive Staphylococcus argenteus among Patients with Bacteremia in Hong Kong

Prevalence and Characteristics of Invasive Staphylococcus argenteus among Patients with Bacteremia in Hong Kong

Fatal bacteremia caused by Staphylococcus argenteus: A case report

Sex differences and testosterone interfere with the structure of the gut microbiota through the bile acid signaling pathway

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