<i>Staphylococcus aureus</i>colonization in atopic dermatitis and its therapeutic implications

Abeck,; Mempel,

doi:10.1046/j.1365-2133.1998.1390s3013.x

Cited by 146 publications

(111 citation statements)

References 24 publications

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“…The inflammation development mechanism was another aspect under discussion. Staphylococcal proteins and toxins are listed here, especially those which are superantigens [4]. The study by Goh et al resulted in the following findings: S. aureus was isolated in 69.7% of eczematous lesions and 42% of cases of apparently healthy skin in AD patients.…”

Section: Discussionmentioning

confidence: 90%

“…There are elaborate descriptions of disorders in the structure and function of the epidermal barrier [3]. The significance of microbiological factors in the pathogenesis of eczema and the resulting therapeutic implications have been under discussion for over 100 years [4]. It is widely known that inflammation in the course of AD is stimulated by the antigens of skin-colonising microorganisms.…”

Section: Introductionmentioning

confidence: 99%

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Skin and nasal vestibule colonisation by Staphylococcus aureus and its susceptibility to drugs in atopic dermatitis patients

Wróbel¹,

Tomczak²,

Jenerowicz³

et al. 2018

Ann Agric Environ Med.

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Introduction. Atopic dermatitis (AD) is a chronic and recurrent disease with an inflammatory background. Genetic and environmental factors are responsible for the occurrence and development of this dermatosis. Objective. The aim of the study was to assess the frequency of colonisation of the nasal vestibule and apparently healthy skin by S. aureus, and to assess dermal lesions for superinfection with S. aureus in AD patients. Materials and method. The research was performed on a population of 100 AD patients. Three smears were collected for microbiological investigations: from the anterior nares, from apparently healthy skin and from lesioned skin. On collection, the material was cultured on mediums provided by the bioMerieux and Argenta companies. The strains were identified and their sensitivity to antibiotics assessed by means of the Vitek2 system (bioMerieux). Results. S. aureus was present in at least one location in 90%. 44% presented S. aureus colonization of apparently healthy skin and within skin lesions. In the case of 23%, this particular pathogen was detected only in skin lesions, whereas 6% had a positive result within the area of apparently healthy skin. In total, S. aureus was detected in the skin of 73%. In 61%, apparently healthy skin had been colonized with S. aureus, whereas in 81% colonization was proved within the skin lesions. S. aureus was detected in the nasal vestibule of 85%. Among the group with S. aureus in their anterior nares, the pathogen was also found on the skin surface of 77%. Conclusions. S. aureus colonises skin in most AD patients. Most AD patients carry S. aureus in their nasal vestibules. S. aureus does not seem to colonise healthy skin as often as skin lesions in young people. The vast majority of S. aureus strains were sensitive to local antibiotics. Most S. aureus strains produced penicillinase.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Skin and nasal vestibule colonisation by Staphylococcus aureus and its susceptibility to drugs in atopic dermatitis patients

Wróbel¹,

Tomczak²,

Jenerowicz³

et al. 2018

Ann Agric Environ Med.

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“…Upon exacerbation of skin lesions, staphylococci may be cultured from most of these skin lesions, and many of these staphylococcus strains are potent producers of staphylococcal superantigens (91,92). On one hand, these superantigens are presented as`o rdinary'' antigens in the peptide-presenting groove of the MHC complex to the respective antigen-speci®c T cell.…”

Section: S H Staphylococcal Superantigensmentioning

confidence: 99%

Atopic dermatitis: from the genes to skin lesions

Wollenberg

Bieber

2000

Allergy

118

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“…Whereas skin infections caused by Gram-negative bacteria are rather rare, S. aureus is a major cause for skin and lung infections, in particular in atopic dermatitis (23). The high abundance of hBD-2 in skin (16) might explain its high resistance against Gram-negative bacterial infection.…”

mentioning

confidence: 99%

Isolation and Characterization of Human μ-Defensin-3, a Novel Human Inducible Peptide Antibiotic

Harder

Bartels

Christophers

et al. 2001

Journal of Biological Chemistry

1,236

1,190

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The growing public health problem of infections caused by multiresistant Gram-positive bacteria, in particular Staphylococcus aureus, prompted us to screen human epithelia for endogenous S. aureus-killing factors. A novel 5-kDa, nonhemolytic antimicrobial peptide (human ␤-defensin-3, hBD-3) was isolated from human lesional psoriatic scales and cloned from keratinocytes. hBD-3 demonstrated a salt-insensitive broad spectrum of potent antimicrobial activity against many potentially pathogenic microbes including multiresistant S. aureus and vancomycin-resistant Enterococcus faecium. Ultrastructural analyses of hBD-3-treated S. aureus revealed signs of cell wall perforation. Recombinant hBD-3 (expressed as a His-Tag-fusion protein in Escherichia coli) and chemically synthesized hBD-3 were indistinguishable from naturally occurring peptide with respect to their antimicrobial activity and biochemical properties. Investigation of different tissues revealed skin and tonsils to be major hBD-3 mRNA-expressing tissues. Molecular cloning and biochemical analyses of antimicrobial peptides in cell culture supernatants revealed keratinocytes and airway epithelial cells as cellular sources of hBD-3. Tumor necrosis factor ␣ and contact with bacteria were found to induce hBD-3 mRNA expression. hBD-3 therefore might be important in the innate epithelial defense of infections by various microorganisms seen in skin and lung, such as cystic fibrosis.

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Staphylococcus aureuscolonization in atopic dermatitis and its therapeutic implications

Cited by 146 publications

References 24 publications

Skin and nasal vestibule colonisation by Staphylococcus aureus and its susceptibility to drugs in atopic dermatitis patients

Skin and nasal vestibule colonisation by Staphylococcus aureus and its susceptibility to drugs in atopic dermatitis patients

Atopic dermatitis: from the genes to skin lesions

Isolation and Characterization of Human μ-Defensin-3, a Novel Human Inducible Peptide Antibiotic

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