<i>Staphylococcus epidermidis</i> role in the skin microenvironment

Leonel, Caroline; Sena, Isadora F. G.; Silva, Walison N.; Prazeres, Pedro H. D. M.; Fernandes, Gabriel R.; Agresti, Pamela Mancha; Drumond, Mariana Martins; Mintz, Akiva; Azevedo, Vasco; Birbrair, Alexander

doi:10.1111/jcmm.14415

Cited by 35 publications

(25 citation statements)

References 93 publications

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“…As described above, skin commensal organisms are in constant crosstalk with the immune system and are thus also involved in wound healing. Leonel et al [ 33 ] synthetized the current knowledge of this topic, which appears to be conflicting. For example, the absence of commensal skin microorganisms has been shown to have a positive effect on wound closure during healing [ 34 ].…”

Section: Role Of the Skin Microbiomementioning

confidence: 99%

Challenges in exploring and manipulating the human skin microbiome

Cenizo²,

et al. 2021

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The skin is the exterior interface of the human body with the environment. Despite its harsh physical landscape, the skin is colonized by diverse commensal microbes. In this review, we discuss recent insights into skin microbial populations, including their composition and role in health and disease and their modulation by intrinsic and extrinsic factors, with a focus on the pathobiological basis of skin aging. We also describe the most recent tools for investigating the skin microbiota composition and microbe-skin relationships and perspectives regarding the challenges of skin microbiome manipulation.

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Section: Role Of the Skin Microbiomementioning

confidence: 99%

Challenges in exploring and manipulating the human skin microbiome

Cenizo²,

et al. 2021

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“…The disease is commonly originated as a consequence of the stepwise agglomeration of genetic and epigenetic alterations in melanocytes; nonetheless the tumour microenvironment plays a dynamic role in regulating the subsequent tumour growth 5 . Physiologically, the skin microenvironment in healthy people is a physical and chemical barrier that protects from tumorigenesis; nevertheless, cancer cells evoke numerous changes to transform the adjacent normal cells into pathological entities 6 . The orchestration of such events implicates expansion, migration and contribution of various cell types 7 .…”

Section: Introductionmentioning

confidence: 99%

Ablation of sensory nerves favours melanoma progression

Prazeres

Leonel

Silva

et al. 2020

J Cellular Molecular Medi

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The tumour mass is composed not only of heterogeneous neoplastic cells, but also a variety of other components that may affect cancer cells behaviour. The lack of detailed knowledge about all the constituents of the tumour microenvironment restricts the design of effective treatments. Nerves have been reported to contribute to the growth and maintenance of numerous tissues. The effects of sensory innervations on tumour growth remain unclear. Here, by using state‐of‐the‐art techniques, including Cre/loxP technologies, confocal microscopy, in vivo‐tracing and chemical denervation, we revealed the presence of sensory nerves infiltrating within the melanoma microenvironment, and affecting cancer progression. Strikingly, melanoma growth in vivo was accelerated following genetic ablation or chemical denervation of sensory nerves. In humans, a retrospective analysis of melanoma patients revealed that increased expression of genes related to sensory nerves in tumours was associated with better clinical outcomes. These findings suggest that sensory innervations counteract melanoma progression. The emerging knowledge from this research provides a novel target in the tumour microenvironment for therapeutic benefit in cancer patients.

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“…Using swab samples, we found some albeit small differences and trends in differential abundance of microbial composition between healthy and vitiligo skin swabs; the largest differences seen in depletion of commensal Staphylococcus and Acinetobacter and enrichment of pathogenic Paracoccus ( Proteobacteria) in lesional skin. Staphylococcus epidermidis is a known important symbiont in the skin which directly interacts with cutaneous immune cells to regulate skin homeostasis [21]. Staphylococcus spp are also known to colonise lesions in a number of dermatological diseases including atopic dermatitis and presents propensity to form biofilms; adhesive surface-attached colonies that become highly resistant to antibiotics and immune responses [22].…”

Section: Discussionmentioning

confidence: 99%

Deep skin dysbiosis in vitiligo patients: link with mitochondrial and immune changes

Bzioueche

West

et al. 2020

Preprint

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Rationale: Vitiligo is an autoimmune-disease characterized by patchy, white skin due to melanocyte loss. Commensal cutaneous or gut dysbiosis have been linked to various dermatological disorders. Here, we studied skin and gut microbiota of vitiligo patients compared to healthy controls. Methods: We recruited 20 subjects and obtained swabs and biopsies from lesional and non-lesional skin, stool and blood from each individual (total 100 samples). Results: We detected reduced richness and distribution of microbiota in stool of vitiligo subjects compared to controls (P<0.01). Skin swabs had greater alpha-diversity than skin biopsies (P<0.001), however only trends were seen between groups when examining microbiota at the skin surface. This was in contrast to sampling deeper layers of skin from the same patients which showed decreased richness and distribution of species (P<0.01) but greater phylogenetic diversity (P<0.01) in lesional compared to non-lesional sites. Biopsy microbiota from the lesional skin had distinct microbiota composition which was depleted of protective Bifidobacterium and enriched in Terenicutes, Streptococcus, Mycoplasma and mitochondrial DNA (P<0.001); the latter was linked with increased innate immunity and stress markers in the blood of the same patients (P<0.05). Conclusion: These data describe vitiligo-specific cutaneous and gut microbiota and, for the first time in humans, a link between mitochondrial alteration, innate immunity and skin microbiota.

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Staphylococcus epidermidis role in the skin microenvironment

Cited by 35 publications

References 93 publications

Challenges in exploring and manipulating the human skin microbiome

Challenges in exploring and manipulating the human skin microbiome

Ablation of sensory nerves favours melanoma progression

Deep skin dysbiosis in vitiligo patients: link with mitochondrial and immune changes

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