<i>Stevia rebaudiana</i>extract attenuate metabolic disorders in diabetic rats<i>via</i>modulation of glucose transport and antioxidant signaling pathways and aquaporin‐2 expression in two extrahepatic tissues

Bayat, Elahe; Rahpeima, Zahra; Dastghaib, Sanaz; Gholizadeh, Fatemeh; Erfani, Mehran; Asadikaram, Gholamreza; Mokarram, Pooneh

doi:10.1111/jfbc.13252

Cited by 7 publications

(3 citation statements)

References 55 publications

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“…Our initial hypothesis, that both stevia leaf extracts and pure stevia glycosides could possess antioxidant activity, though to different extents, appears to have a biological basis. Polyphenolic compounds from a plethora of plant resources have repeatedly been shown to display antioxidant potential [79][80][81] in direct assays [20,82] and exert effective antioxidant activity in vivo, including cell lines [20], experimental animals [83], or even humans [84]. Our findings suggest that stevia glycosides do possess a limited antioxidant activity.…”

Section: Meta-analysis Of Lipid Peroxidation (Mda) Assay Datasetsmentioning

confidence: 68%

Antioxidant Activity of Leaf Extracts from Stevia rebaudiana Bertoni Exerts Attenuating Effect on Diseased Experimental Rats: A Systematic Review and Meta-Analysis

et al. 2023

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Stevia (Stevia rebaudiana Bertoni) is an aromatic plant known for its high sweetening power ascribed to its glycosides. Stevia also contains several bioactive compounds showing antioxidant, antiproliferative, antimicrobial, and anti-inflammatory activities. Since inflammation and oxidative stress play critical roles in the pathogenesis of many diseases, stevia emerges as a promising natural product that could support human health. In this study we set out to investigate the way stevia affects oxidative stress markers (e.g., SOD, CAT, GPx, GSH, MDA) in diseased rats administered stevia leaf extracts or glycosides. To this end, we performed an inclusive literature search, following PRISMA guidelines, and recruited multivariate meta-analysis and meta-regression to synthesize all available data on experimental animal models encountering (a) healthy, (b) diseased, and (c) stevia-treated diseased rats. From the 184 articles initially retrieved, 24 satisfied the eligibility criteria, containing 104 studies. Our results demonstrate that regardless of the assay employed, stevia leaf extracts restored all oxidative stress markers to a higher extent compared to pure glycosides. Meta-regression analysis revealed that results from SOD, CAT, GSH, and TAC assays are not statistically significantly different (p = 0.184) and can be combined in meta-analysis. Organic extracts from stevia leaves showed more robust antioxidant properties compared to aqueous or hydroalcoholic ones. The restoration of oxidative markers ranged from 65% to 85% and was exhibited in all tested tissues. Rats with diabetes mellitus were found to have the highest restorative response to stevia leaf extract administration. Our results suggest that stevia leaf extract can act protectively against various diseases through its antioxidant properties. However, which of each of the multitude of stevia compounds contribute to this effect, and to what extent, awaits further investigation.

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Section: Meta-analysis Of Lipid Peroxidation (Mda) Assay Datasetsmentioning

confidence: 68%

Antioxidant Activity of Leaf Extracts from Stevia rebaudiana Bertoni Exerts Attenuating Effect on Diseased Experimental Rats: A Systematic Review and Meta-Analysis

et al. 2023

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“…Aktivitas antidiabetes menurut Ahmad [7] dan Bayat [8] atau pengkelat yang dapat mengkerutkan membran epitel usus halus sehingga mengurangi penyerapan sari makanan akibatnya menghambat asupan glukosa dan laju peningkatan glukosa tidak terlalu tinggi.…”

Section: Aktivitas Stevia Rebaudiana Bertoni Sebagai Antidiabetesunclassified

“…Kandungan steviosida diduga mampu mengatur kadar glukosa darah akhir dengan meningkatkan sekresi dan sensitivitas insulin. Hal ini sejalan dengan penelitian Bayat[8] yang menyebutkan bahwa ekstrak air Stevia rebaudiana mengandung steviol dan steviosida yang mampu meningkatkan transkip mRNA GLUT4 dalam kultur myotub dan adiposit. Serta penurunan ekspresi gen Fosfoenolpiruvat karboksikinase (PEPCK) di hati tikusAktivitas Vernonia amygdalina Del Sebagai AntidiabetesMenurut penelitian Tuldjanah[6] dan Ong[9] ekstrak etanol daun Vernonia amygdalina memiliki aktivitas antidiabetes dengan menunjukkan kadar penurunan glukosa darah pada tikus diabetes.…”

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Studi Literatur Aktivitas Antidiabetes pada Tiga Tanaman Suku Asteraceae Secara In Vivo

Yudita

Choesrina

2022

JRF

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Abstract. Diabetes Mellitus or often referred to as diabetes is a chronic disease that arises when the body is unable to produce enough insulin or cannot use insulin (insulin resistance) which is characterized by hyperglycemia. Plants originating from the Asteraceae tribe can be used as traditional medicine because they have components of bioactive compounds, such as sesquiterpenes, lactones, pentacyclic triterpenes, alkaloids, tannins, polyphenols, saponins, and sterols that can be used for medicinal purposes. The purpose of this study was to determine the activity and content of compounds as well as the mechanism of action as antidiabetic from the Asteraceae tribe. This study uses a systematic literature review method derived from 6 articles. The plant extracts used in this study consisted of 3 types of plants, namely Stevia rebaudiana Bertoni, Vernonia amygdalina Del, and Cosmos caudatus Kunth. Stevia rebaudiana Bertoni contains stevioside which regulates final blood glucose levels by increasing insulin secretion and sensitivity as well as its ability to regulate protein expression. Meanwhile, Vernonia amygdalina Del, and Cosmos caudatus Kunth contain flavonoid compounds, alkaloids, saponins, and tannins that play a role in reducing glucose levels. This content is able to regenerate damaged pancreatic cells and improve insulin receptor sensitivity. Abstrak. Diabetes Melitus atau yang sering disebut dengan kencing manis yaitu suatu penyakit kronik yang timbul saat tubuh tidak mampu memproduksi insulin yang cukup atau tidak dapat menggunakan insulin (resistensi insulin) yang ditandai dengan terjadinya hiperglikemia. Tanaman yang berasal dari suku Asteraceae dapat dimanfaatkan sebagai obat tradisional karena memiliki komponen senyawa bioaktif, seperti seskuiterpen, lakton, triterpen pentasiklik, alkaloid, tanin, polifenol, saponin, dan sterol yang dapat digunakan untuk bahan pengobatan. Tujuan dari penelitian ini yaitu untuk mengetahui aktivitas, dan kandungan senyawa serta mekanisme kerja sebagai antidiabetes dari suku Asteraceae. Penelitian ini menggunakan metode systematic literature review yang berasal dari 6 artikel. Ekstrak yang digunakan dalam penelitian ini terdiri dari 3 jenis tanaman yaitu daun Stevia rebaudiana Bertoni, Vernonia amygdalina Del, dan Cosmos caudatus Kunth. Stevia rebaudiana Bertoni memiliki kandungan steviosida yang mengatur kadar glukosa darah akhir dengan meningkatkan sekresi dan sensitivitas insulin serta kemampuannya untuk mengatur ekspresi protein. Sedangkan untuk Vernonia amygdalina Del, dan Cosmos caudatus Kunth mengandung senyawa flavonoid, alkaloid, saponin, tannin yang berperan pada penurunan kadar glukosa. Kandungan ini yang mampu meregenerasi sel β pankreas yang rusak dan memperbaiki sensitivitas reseptor insulin.

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Targeting apoptosis and unfolded protein response: the impact of β-hydroxybutyrate in clear cell renal cell carcinoma under glucose-deprived conditions

Roohy,

Siri,

Kohansal

et al. 2024

Mol Biol Rep

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Stevia rebaudianaextract attenuate metabolic disorders in diabetic ratsviamodulation of glucose transport and antioxidant signaling pathways and aquaporin‐2 expression in two extrahepatic tissues

Cited by 7 publications

References 55 publications

Antioxidant Activity of Leaf Extracts from Stevia rebaudiana Bertoni Exerts Attenuating Effect on Diseased Experimental Rats: A Systematic Review and Meta-Analysis

Antioxidant Activity of Leaf Extracts from Stevia rebaudiana Bertoni Exerts Attenuating Effect on Diseased Experimental Rats: A Systematic Review and Meta-Analysis

Studi Literatur Aktivitas Antidiabetes pada Tiga Tanaman Suku Asteraceae Secara In Vivo

Targeting apoptosis and unfolded protein response: the impact of β-hydroxybutyrate in clear cell renal cell carcinoma under glucose-deprived conditions

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