<i>Streptococcus agalactiae</i> Serotype IV in Humans and Cattle, Northern Europe1

Lyhs, Ulrike; Kulkas, Laura; Katholm, J.; Waller, Karin Persson; Saha, Kerttu; Tomusk, Richard J.; Zadoks, Ruth N.

doi:10.3201/eid2212.151447

Cited by 70 publications

(115 citation statements)

References 36 publications

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“…It is the major cause of infectious disease in neonates in western countries and it is recognized as emerging pathogen in adults worldwide. People can also be asymptomatic carriers of the organism (Brochet et al, 2006;Lyhs et al, 2016). Streptococcus agalactiae is a very common pathogen of dairy cattle in several regions of Colombia, with prevalence estimates of 11 to 60% at the herd level (Keefe et al, 2011) and 35% at the cow level (Ramírez et al, 2014).…”

Section: Short Communicationmentioning

confidence: 99%

Short communication: Molecular epidemiology of Streptococcus agalactiae differs between countries

Reyes

Chaffer

Rodríguez-Lecompte

et al. 2017

Journal of Dairy Science

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Group B Streptococcus or Streptococcus agalactiae continue to be challenging for milk quality programs in countries with emerging dairy industries, such as Colombia, where high prevalence has been reported. Molecular typing of isolates is needed to understand the variability and epidemiology of this pathogen and to develop effective control and eradication programs. We characterized the molecular profile of Strep. agalactiae isolated from cows with subclinical mastitis in 21 Colombian dairy herds and measured diversity within and between herds using multilocus sequence typing. Isolates belonged to sequence type 248 [clonal complex (CC) 103; n = 30), ST1 (CC1; n = 6) or ST22 (CC22; n = 4)], whereas members of CC67/61, the dominant type in North America, were not detected. Presence of multiple clonally unrelated sequence type within a herd was common, which contrasts with the situation in European countries and suggests introduction from multiple sources. Our results demonstrate that conclusions from molecular epidemiological studies in 1 region cannot necessarily be extrapolated to other regions, and no single bovine-adapted CC of Strep. agalactiae exists in Colombia. Improvements in internal and external biosecurity will be needed to reduce Strep. agalactiae prevalence in Colombian dairy herds.

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Section: Short Communicationmentioning

confidence: 99%

Short communication: Molecular epidemiology of Streptococcus agalactiae differs between countries

Reyes

Chaffer

Rodríguez-Lecompte

et al. 2017

Journal of Dairy Science

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“…ST196 is a successful coloniser [3] as well as an essential cause of invasive disease in adults [20]. This clone has also been linked to transmission between humans and cattle [21]. Several studies have associated ST196 with serotype IV [22].…”

Section: Discussionmentioning

confidence: 99%

Within-Host Diversity and Vertical Transmission of Group B Streptococcus Among Mother-infant Dyads in The Gambia

Foster-Nyarko

Senghore

Kwambana-Adams

et al. 2019

Preprint

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IntroductionUnderstanding mother-to-infant transmission of Group B Streptococcus (GBS) is vital to the prevention and control of GBS disease. We investigated the transmission and phylogenetic relationships of mothers colonised by GBS and their infants in a peri-urban setting in The Gambia. MethodsWe collected nasopharyngeal swabs from 35 mother-infant dyads at weekly intervals from birth until six weeks post-partum. GBS was isolated by conventional microbiology techniques. Whole-genome sequencing was performed on GBS isolates from one motherinfant dyad (dyad 17). ResultsWe recovered 85 GBS isolates from the 245 nasopharyngeal swabs. GBS was isolated from 16.33% and 18.37% of sampled mothers and infants, respectively. In 87% of cultured swabs, the culture status of an infant agreed with that of the mother (Kappa p-value <0.001). In dyad 17, phylogenetic analysis revealed within-host strain diversity in the mother and clone to her infant. ConclusionGBS colonisation in mothers presents a significant risk of colonisation in their infants. We confirm vertical transmission from mother to child in dyad 17, accompanied by within-host diversity.

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“…Despite some level of host adaptation, e.g. association of sequence type (ST) 67 with cattle 14 and association of ST7, ST283 and clonal complex (CC) 552 with poikilothermic animals 15 , host-association is not absolute and interspecies transmission between people, cattle and fish may occur 12,16,17 .…”

Section: Introductionmentioning

confidence: 99%

Galleria mellonellaas an infection model for the multi-host pathogenStreptococcus agalactiaereflects hypervirulence of ST283

Kranjangwong

Crumlish

et al. 2018

Preprint

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Streptococcus agalactiae, or group B streptococcus (GBS), infects diverse hosts including humans, economically important livestock and fishes. In the context of human health, GBS is a major cause of neonatal infections and an emerging cause of invasive disease in adults. Here we show that GBS is able to establish a systemic infection in G. mellonella larvae that is associated with extensive bacterial replication and dose dependent larval survival. This infection model is suitable for use with GBS isolates from both homeothermic and poikilothermic hosts and a hypervirulent sequence type (ST) associated with invasive human disease, ST283, shows increased virulence in this model, indicating it may be useful in studying GBS virulence determinants. In addition, we demonstrate that larval survival can be afforded by antibiotic treatment and so the model may also be useful in the development of novel anti-GBS strategies.The use of G. mellonella in GBS research has the potential to provide a low cost infection model that could reduce the number of vertebrates used in the study of GBS infection.

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Streptococcus agalactiae Serotype IV in Humans and Cattle, Northern Europe1

Abstract: Cattle may be a reservoir for this emerging pathogen of humans.

Cited by 70 publications

References 36 publications

Short communication: Molecular epidemiology of Streptococcus agalactiae differs between countries

Short communication: Molecular epidemiology of Streptococcus agalactiae differs between countries

Within-Host Diversity and Vertical Transmission of Group B Streptococcus Among Mother-infant Dyads in The Gambia

Galleria mellonellaas an infection model for the multi-host pathogenStreptococcus agalactiaereflects hypervirulence of ST283

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