<i>Streptococcus gordonii</i>-associated infective endocarditis in a girl with Barlow’s mitral valve disease

Komorovsky, Roman; Boyarchuk, Oksana; Synytska, Vira O

doi:10.1017/s1047951119001434

Cited by 12 publications

(19 citation statements)

References 10 publications

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“…There is a correlation between the severity of destructive processes in the connective tissue and antibody formation, which explains the higher frequency of development of autoimmune reactions, including rheumatic diseases, in children with HDCT [21]. Patients with degenerative mitral valve disease are more likely to develop bacterial endocarditis, and RHD [6,22]. A dysplastic valve or other structural heart abnormalities can lead to changes in blood flow or development of blood flow turbidity, which makes the valves even more susceptible to inflammatory and degenerative lesions.…”

Section: Discussionmentioning

confidence: 99%

“…Heritable disorders of connective tissue is often associated with heart abnormalities such as: mitral valve prolapse, mildly dilated aortic root, bilateral stenosis of the carotids, and aortic dilation [5]. These patients are Reumatologia 2020; 58/1 have high probability of developing bacterial endocarditis and rheumatic heart disease (RHD) [6].…”

Section: Introductionmentioning

confidence: 99%

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Features of heritable disorders of connective tissue in children with acute rheumatic fever and rheumatic heart disease

Boyarchuk

2020

Reumatologia

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Objectives: Heritable disorders of connective tissue (HDCT) are associated with morphological and functional disorders of different organs and systems. The aim of our study was to determine the clinical signs of heritable disorders of connective tissue and oxyproline levels in children with acute rheumatic fever (ARF) and rheumatic heart disease (RHD). Material and methods: A total of 155 patients aged 4 to 17 years participated in the study: 23 with ARF, 78 with RHD, and 54 healthy patients with a history of ARF. All patients underwent a standardized examination protocol, which consisted of a detailed medical history recorded by the physician, general and special laboratory tests, electrocardiogram, echocardiography, and Doppler echocardiography. Special attention was paid to the clinical signs of HDCT. The intensity of the metabolic processes in the connective tissue was evaluated by serum oxyproline levels. Results: The signs of HDCT were revealed in 121 (78.1%) of the patients with ARF and RHD. Among cardiovascular manifestations, we observed mitral valve prolapse most often-in 91 (58.7%) patients. Musculoskeletal anomalies were observed in 94 (60.7%) patients. Both groups of patients with ARF and RHD had elevated mean serum oxyproline levels. Conclusions: Children with acute rheumatic fever and rheumatic heart disease presented with a number of signs characteristic of heritable connective tissue disorders. The cardiovascular and musculoskeletal system changes are the most frequent among all features of HDCT. Elevated levels of serum oxyproline in patients with ARF and RHD confirm connective tissue disorders. Children with manifestations of HDCT are at the risk of ARF and RHD development.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Features of heritable disorders of connective tissue in children with acute rheumatic fever and rheumatic heart disease

Boyarchuk

2020

Reumatologia

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“…Rhd developed in 40%-50% of ARF patients (8). Poor secondary prophylaxis is one of the main reasons for recurrent RF (2,9), although recent literature shows that poor secondary prophylaxis is not associated with an increased risk of Rhd in developed countries (10). Some social and environmental factors in GAS infection and progression of ARF and Rhd have been studied comprehensively (2,9,11,12).…”

Section: Introductionmentioning

confidence: 99%

“…Poor secondary prophylaxis is one of the main reasons for recurrent RF (2,9), although recent literature shows that poor secondary prophylaxis is not associated with an increased risk of Rhd in developed countries (10). Some social and environmental factors in GAS infection and progression of ARF and Rhd have been studied comprehensively (2,9,11,12). Among them, household crowding, poor hygiene, living in a rural area, unemployed status, illiteracy, low monthly income, maternal employment, and less access to good quality healthcare are pointed out (10,11,13).…”

Section: Introductionmentioning

confidence: 99%

The correlation between cytokine concentrations and IgG/IgM antibodies to viruses of the Herpesviridae family in children with rheumatic heart disease

Boyarchuk¹

2021

Paediatr Croat

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Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) are still urgent medical issues in developing countries and in some communities of high-income countries. The aim of our study was to evaluate plasma cytokine concentrations in children with RHD and their correlation with antibody concentrations to viruses of the Herpesviridae family. Sixty-two patients with RHD aged 8 to 17 years were included in the study. The concentrations of TNF-α, IL-4, IL-8, IL-10 and IFN-γ were evaluated; IgG and IgM antibodies to cytomegalovirus (CMV), herpes simplex virus (HSV) groups I-II and Epstein-Barr virus (EBV) in serum were determined by ELISA method. A significant increase of cytokine concentrations (TNF-α, IL-8, IL-4 and IL-10) was recorded in RHD patients. Antibodies to intracellular Herpesviridae family viruses were detected in all children with RHD. Children with RHD were significantly more likely to have IgG HSV I-II antibodies, and IgG and IgM EBV antibodies compared to controls (p<0.05). The concentration of IgM antibody to CMV showed positive correlation with TNF-α; the concentration of IgG antibody to EBV showed negative correlation with TNF-α; and the concentration of IgG and IgM antibodies to EBV showed positive correlation with IL-10 levels. Considering positive correlation of IL-10 concentration with IgG and IgM antibody concentrations to EBV, and the significance of IL-10 in the progression of RHD, the possible predisposing role of EBV in the progression of RHD can be postulated, which needs further study.

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“…Systemic arthritis differs from the other categories of JIA and is characterized by an autoinflammatory fenotype [1][2][3]. Fever may be the main manifestation in the onset of the disease and it may frequently get misdiagnosed as a bacterial or viral infection, malignancy, or another systemic disease [1,6]. The diagnosis is previously based on clinical data [1,3].…”

Section: Introductionmentioning

confidence: 99%

Clinical variability of the systemic juvenile idiopathic arthritis course: literature review based on case series

Boyarchuk¹,

Kovalchuk²,

Kovalchuk³

et al. 2020

Reumatologia

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Systemic juvenile idiopathic arthritis (sJIA) is a heterogeneous category of arthritis that frequently leads to disability and severe complications. The clinical cause of sJIA is very variable, which results in difficulties of disease recognition.<br /> In this literature review based on case series we outline the main challenges in diagnostic of sJIA and macrophage activation syndrome (MAS). Using the 2016 criteria for MAS diagnostic allowed to consider MAS in the diagnostically challenging cases, that confirms their sensitivity in pediatric patients. The reviewed literature showed last updates for the improvement of classification, diagnostic of sJIA and its complication. The modification of JIA criteria, initiated by Paediatric Rheumatology International Trials Organisation, will allow to improve detection and treatment of JIA. <br /> The presentation of this clinical cases and the discussion may be useful for understanding the disease cause and will help to differentiate sJIA and MAS from other disorders, and to improve treatment outcomes.

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Streptococcus gordonii-associated infective endocarditis in a girl with Barlow’s mitral valve disease

Cited by 12 publications

References 10 publications

Features of heritable disorders of connective tissue in children with acute rheumatic fever and rheumatic heart disease

Features of heritable disorders of connective tissue in children with acute rheumatic fever and rheumatic heart disease

The correlation between cytokine concentrations and IgG/IgM antibodies to viruses of the Herpesviridae family in children with rheumatic heart disease

Clinical variability of the systemic juvenile idiopathic arthritis course: literature review based on case series

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