<i>Streptococcus pyogenes</i> Infective Endocarditis—Association With Injection Drug Use: Case Series and Review of the Literature

Rebechi, Melanie; Heil, Emily L.; Luethy, Paul M.; Schmalzle, Sarah

doi:10.1093/ofid/ofab240

Cited by 4 publications

(1 citation statement)

References 37 publications

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“…Streptococcus pyogenes или Streptococcus группы A ранее считались достаточно редкими возбудителями ИЭ как в общей популяции, так и у ПИН. Однако в сообщении M. Rebechi et al (2021) отмечен рост случаев ИЭ, вызванных S. pyogenes или S. группы A, причем из 18 пациентов с ИЭ указанной этиологии, 16 (89 %) -принимали инъекционные наркотики [25].…”

Section: инфекционный эндокардит у лиц применяющих внутривенные нарко...unclassified

Etiological Structure of Infective Endocarditis in Certain Categories of Patients (Literature Review)

Ракитская

Тарадин

Ponomareva

et al. 2023

Arhivʺ vnutrennej mediciny

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The review contains information about the most common pathogens of infective endocarditis (IE) in certain categories of patients. Basing on analysis of current national and foreign sources concerning IE study there are description of conditions favoring to dominance of various microorganisms in intravenous drug users, HIV-infected patients, patients on hemodialysis, with valve prostheses, diabetes mellitus and malignant neoplasm patients, elderly patients, and pregnant women.Distribution of both as typical for IE (staphylococci, streptococci, enterococci) and rare microorganisms as well polymicrobial endocarditis in mentioned above groups is considered. There is discussion about possible reasons of prevalence of methicillin-sensitive or methicillin-resistant Staphylococcus aureus species in different IE patient categories, disease development initiated by rare forms of microbial agents in immunosuppressive patients, microbial flora features depending on terms valvular infection after valve prosthetics. Despite on consideration about predominance of one or another microorganism as an etiologic agent of IE in given clinical situation, during medical help providing it should strive for precise verification of an etiologic factor for choice of effective antibacterial treatment.

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Section: инфекционный эндокардит у лиц применяющих внутривенные нарко...unclassified

Etiological Structure of Infective Endocarditis in Certain Categories of Patients (Literature Review)

Ракитская

Тарадин

Ponomareva

et al. 2023

Arhivʺ vnutrennej mediciny

View full text Add to dashboard Cite

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Advancing engineered approaches for sustainable wound regeneration and repair: Harnessing the potential of green synthesized silver nanoparticles

Nandhini,

Karthikeyan,

Elizabeth Rani

et al. 2024

Engineered Regeneration

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Streptococcus pyogenes Bacteremia at a Large Teaching Hospital

Rich,

Hatch,

Oravec

et al. 2025

Infect Dis Clin Pract

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Objectives The aims of the study were to review Streptococcus pyogenes bacteremia (SPB) at our 570-bed teaching hospital from 2018 to 2022 and to report epidemiology, source of SPB, comorbidities, treatment, and mortality. Methods This was deemed to be an institutional review board–exempt quality improvement project of our internal medicine residency. We reviewed records of adults (≥16 years) with SPB admitted to hospital during 5-year period from 2018 to 2022. Age, gender, date and source of bacteremia, comorbidities, antimicrobial therapy, and mortality were recorded for each patient. Comparisons to data from our 2007–2016 study were performed using Fisher's exact test with 2-tailed P value. Results There were 102 episodes of SPB during the 5-year period: 64 men (62.7%) and 38 women (37.3%). Incidence was 4.39/104 hospital discharges (HD) in 2018, 6.79/104 HD in 2019, 6.67/104 HD in 2020, 6.16/104 HD in 2021 and 5.83/104 HD in 2022. Age range was 21–94 years with mean = 56.5 years. Sources of bacteremia: skin/soft tissue infection in 52/102 (51.0%), pneumonia in 15/102 (14.7%), bone/joint infection in 13/102 (12.7%), and primary infection in 8/102 (7.8%) episodes. Other sources were as follows: endometritis (3 patients), intra-abdominal infection (3 patients), mastoiditis (2 patients), endocarditis (1 patient), and miscellaneous (4 patients). Diabetes mellitus (36.2%), injection drug use (IDU) (29.8%), chronic obstructive pulmonary disease (24.5%), and chronic liver disease (23.4%) were the most common comorbidities. The mortality rate was 15.7%. All patients received appropriate/timely initial antimicrobial therapy. Conclusions SPB was more frequent in this 5-year period than during the preceding 10-year period. Skin/soft tissue infection (51.0%) and bone/joint infection (12.7%) were expected sources of SPB but pneumonia (14.7%) was an unexpectedly frequent cause. There was more episodes of bacteremia IDU-related, 29.8% in this study, than the 7.4% in our prior study (P = 0.0004). Mortality was higher (15.7%) than in our prior study (10.3%) but this difference did not achieve statistical significance (P = 0.3663). SPB is not uncommon, is frequently associated with IDU, causes pneumonia more often than expected, and has a 15.7% mortality rate.

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Streptococcus pyogenes Infective Endocarditis—Association With Injection Drug Use: Case Series and Review of the Literature

Cited by 4 publications

References 37 publications

Etiological Structure of Infective Endocarditis in Certain Categories of Patients (Literature Review)

Etiological Structure of Infective Endocarditis in Certain Categories of Patients (Literature Review)

Advancing engineered approaches for sustainable wound regeneration and repair: Harnessing the potential of green synthesized silver nanoparticles

Streptococcus pyogenes Bacteremia at a Large Teaching Hospital

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