I2/DMSO Promoted Metal Free Oxidative Reaction: Facile Synthesis of α‐Amido Hydroxyketones
Satish Bhoge,
Prabal Pratap Singh,
Deepak K. Das
et al.
Abstract:Abstractα‐Amido ketones play a crucial role in the pharmaceutical industry due to their significance. The synthesis of these compounds under metal‐free conditions has been successfully achieved. An efficient hydrogen bond‐assisted method for synthesizing α‐amido hydroxyketones was developed using I2/dimethyl sulphoxide (DMSO) to promote oxidative reactions between various acetophenones and amides. This reaction occurs under mild metal‐free conditions, resulting in the production of the corresponding α‐amido hy… Show more
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