Survivin Gene Polymorphism Association with Tongue Squamous Cell Carcinoma

Abstract

Presence of the C allele was significantly associated with tumor stage and size; therefore, survivin might be an important marker in the prognosis of tongue SCC that requires further investigation.

Survivin Promoter Polymorphism (-31 C/G): A Genetic Risk Factor for Oral Cancer

“…In our study, CG genotype was seen more commonly in oral cancer patients (OR=1.4317 at 95% CI= 0.7513 -2.8658, p-value= 0.31) as compared to GG (OR= 0.4709 at 95% CI= 0.2323-0.9546, p-value= 0.0367) and CC (OR=9.395 at 95% CI= 1.0202-86.5251, p-value= 0.04) genotype. A similar study in Iran also reported the same results, further supporting our findings (Mostaan et al, 2013). Survivin C allele is also reported as a risk factor in colorectal and nasopharyngeal carcinomas (Gazouli et al, 2009;Ma et al, 2011).…”

“…Its expression correlates with translation and transcription level of survivin . A study done in Iran showed that GC and CC genotypes were significantly higher in stage III and IV of OSCC as compared to stage I and II, but it failed to find out any association between survivin -31 SNP and grading of OSCC (Mostaan et al, 2013). Given the fact that survivin is a prognostic marker in many cancers, it seems that there are some therapeutic implications which need to be worked upon in relation to conventional chemotherapy (Kim et al, 2010) .Therefore, we compared the prevalence of -31 SNP of survivin in oral cancer patients and normal healthy adults with no prior history or family history of cancer.…”

BIRC5 Gene Polymorphisms Are Associated with a Higher Stage of Local and Regional Disease in Oral and Oropharyngeal Squamous Cell Carcinomas

“…It has been associated with susceptibility (oral [15,32], esophageal [16,33], colorectal [17,34,35], lung [14], and urinary tract cancers [22,31,[36][37][38][39][40]), survival (colorectal [17] and lung cancers [41]), and age of onset (ovarian [19] and prostate cancers [42]). As in this study, an association was also found with stage and lymph node status (oral [43,44], esophageal [33], pancreatic [45], urinary [36,38,39], lung [46], and colorectal cancers [34]). On the other hand, although Ma et al found that the CC genotype was significantly increased in Chinese nasopharyngeal carcinoma patients, they found no significant association with TNM stage [47].…”

The role of human antigen R (HuR) in modulating proliferation, senescence and radiosensitivity of skin cells

“…Thus, HuR can protect mRNAs from nuclease degradation in the process of translocation from the nucleus to the cytoplasm and increase the stability of mRNAs. HuR has been shown to serve important roles in tumorigenesis and malignant transformation and to regulate oncogenes, the cell cycle, apoptosis, inflammatory factors, invasion, metastasis and related molecules by binding to the target genes (15)(16)(17)(18). In addition, several studies have shown that HuR contributes to the development of resistance to chemotherapy in multiple types of cancer (14,19,20).…”