<i>Sutherlandia frutescens</i>: The Meeting of Science and Traditional Knowledge

Aboyade, Oluwaseyi Mayode; Styger, Gustav; Gibson, Diana; Hughes, Gail

doi:10.1089/acm.2012.0343

Cited by 31 publications

(33 citation statements)

References 36 publications

(52 reference statements)

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“…Sutherlandia is a medicinal plant indigenous to southern Africa and used in folk and contemporary remedies for stress, chronic diseases, cancer, and HIV/AIDS (van Wyk and Albrecht, 2008, Aboyade et al, 2014). In vitro and in vivo studies with extracts prepared from the leaf and whole plant have provided evidence for its anti-proliferative, anti-viral, anti-stress, anti-diabetic, anti-inflammatory, anti-mutagenic, anti-bacterial, anti-oxidant, and immunostimulatory properties (van Wyk and Albrecht, 2008, Aboyade et al, 2014, Tobwala et al, 2014, Lei et al, 2015b).…”

Section: Discussionmentioning

confidence: 99%

“…In vitro and in vivo studies with extracts prepared from the leaf and whole plant have provided evidence for its anti-proliferative, anti-viral, anti-stress, anti-diabetic, anti-inflammatory, anti-mutagenic, anti-bacterial, anti-oxidant, and immunostimulatory properties (van Wyk and Albrecht, 2008, Aboyade et al, 2014, Tobwala et al, 2014, Lei et al, 2015b). Our previous studies with microglial cells showed that ethanol extracts of Sutherlandia suppressed LPS- and IFNγ-induced ROS and NO production by inhibition of the JAK/STAT and ERK1/2 signaling pathways (Jiang et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

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Phytochemicals and botanical extracts regulate NF-κB and Nrf2/ARE reporter activities in DI TNC1 astrocytes

Ajit

Simonyi

Zhao

et al. 2016

Neurochemistry International

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The increase in oxidative stress and inflammatory responses associated with neurodegenerative diseases has drawn considerable attention towards understanding the transcriptional signaling pathways involving NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) and Nrf2 (Nuclear Factor Erythroid 2-like 2). Our recent studies with immortalized murine microglial cells (BV-2) demonstrated effects of botanical polyphenols to inhibit lipopolysaccharide (LPS)-induced nitric oxide (NO) and enhance Nrf2-mediated antioxidant responses (Sun et al., 2015). In this study, an immortalized rat astrocyte (DI TNC1) cell line expressing a luciferase reporter driven by the NF-κB or the Nrf2/Antioxidant Response Element (ARE) promoter was used to assess regulation of these two pathways by phytochemiscals such as quercetin, rutin, cyanidin, cyanidin-3-O-glucoside, as well as botanical extracts from Withania somnifera (Ashwagandha), Sutherlandia frutescens (Sutherlandia) and Euterpe oleracea (Açaí). Quercetin effectively inhibited LPS-induced NF-κB reporter activity and stimulated Nrf2/ARE reporter activity in DI TNC1 astrocytes. Cyanidin and the glycosides showed similar effects but only at much higher concentrations. All three botanical extracts effectively inhibited LPS-induced NF-κB reporter activity. These extracts were capable of enhancing ARE activity by themselves and further enhanced ARE activity in the presence of LPS. Quercetin and botanical extracts induced Nrf2 and HO-1 protein expression. Interestingly, Ashwagandha extract was more active in inducing Nrf2 and HO-1 expression in DI TNC1 astrocytes as compared to Sutherlandia and Açaí extracts. In summary, this study demonstrated NF-kB and Nrf2/ARE promotor activities in DI TNC1 astrocytes, and further showed differences in ability for specific botanical polyphenols and extracts to down-regulate LPS-induced NF-kB and up-regulate the NRF2/ARE activities in these cells.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Phytochemicals and botanical extracts regulate NF-κB and Nrf2/ARE reporter activities in DI TNC1 astrocytes

Ajit

Simonyi

Zhao

et al. 2016

Neurochemistry International

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“…sharing of innovations, solutions to problems and product designs as well as models) between the personnel from formal university research institution and informalsector in Kampala (Uganda). In South Africa, most commercialised geographical indications and pharmaceutical products [44,[53][54][55][56][57][58][59][60] invented/developed by academic researchers were either inspired by traditional knowledge in informal sectors or developed with the help of people in this sector. It therefore makes sense that participants in the current study perceive IP awareness amid academics and students within the university and informal sectors as having potential to ensure that newly formed TTOs receive commercialisable IP and innovative disclosures from people affiliated to the university and those who are not.…”

Section: Intellectual Property Awareness Within and Outside The Univementioning

confidence: 99%

Activities Pivotal for the Sustainability of Newly Established Technology Transfer Offices: A Case Study of Publicly Financed South African Universities

Semenya¹

2020

Intellectual Property Rights - Patent

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The activities with potential to sustain new technology transfer offices (TTOs) within the publicly financed South African universities (PFSAU) and elsewhere are poorly examined. The current chapter thus aims to lay out a series of simple strategic activities which the referred universities can execute to ensure the sustainability of their newly formed TTOs. Data were collected via strategic conversations with intellectual property (IP) experts, and active academic researchers from PFSAU. The activities considered vital for the sustainability of newly formed TTOs in this study encompass extensive training of TTOs staff, IP awareness within and outside the universities, compliance with relevant legislations, learning from well-established TTOs, establishment of IP and innovation policy as well as IP and innovation modules, collaboration with formal and informal sectors outside the universities, execution of applied and industry-driven research by academics and finally, protection and commercialisation of IP. Overall, efficacious executions and implementations of these activities as discussed in the present study will not only contribute towards the sustainability of newly established TTOs within PFSAU but also aid in achieving some of this universities' shared goals such as community engagement, research with economic impact, teaching and learning. However, some of the referred activities can be achieved either over a short or medium periods, but together are crucial stepping stones to continual achievements of long-term goals of TTOs in PFSAU.

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“…Lessertia montana (previously Sutherlandia montana), a member of the Fabaceae family is a South African indigenous plant whose ethnobotanical attributes and indigenous uses were well reported in the work of Ashafa et al (2019). The pharmacological potentials of the leaf and whole plant as an anticancer, anti-stress, antidepressant, anti-HIV, antioxidant and antidiabetic are adequately submitted in the different reports and/ or reviews (van Wyk and Albrecht 2008;Aboyade et al 2014). In fact, the phytochemical determination, antioxidative and antidiabetic properties of the seeds, pods and leaf extracts of the plant were evaluated in our laboratory (Alimi and Ashafa, 2018;Ashafa et al 2019) and these studies revealed the superior pharmacological benefits of the leaves than other parts.…”

Section: Introductionmentioning

confidence: 99%

Potentials of synthesised Lessertia montana zinc oxide nanoparticles on free radicals-mediated oxidative stress and carbohydrate-hydrolysing enzymes

Balogun

Ashafa

2021

Acta Biol Szeged

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The study evaluated the effects of green absorbed zinc oxide nanostructures on oxidative stress-mediated free radicals and carbohydrate-hydrolysing enzymes. The synthesised Lessertia montana zinc oxide nanoparticles were characterised using different spectroscopic, microscopic, and diffraction techniques. The activity of L. montana ZnONPs against 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethyl-benzothiazoline-6-sulfonic acid (ABTS), metal chelating assay, alpha-amylase and alphaglucosidase were determined using standard methods. L. montana ZnONPs were stable nanoparticles (NPs), appeared cubical (predominantly) in shape, and in nanometre range sizes. The synthesised NPs are very active (p < 0.05) against DPPH and alpha-glucosidase (0.120 and 0.037 g/L, respectively) when compared with other samples and controls, quercetin (0.349 g/L) and acarbose (0.065 g/L). However, their interaction with quercetin revealed a good ABTS (0.093 g/L) scavenging and an excellent metal chelating (0.027 g/L) effect compared to other samples. The mode of inhibition of alpha-amylase and alpha-glucosidase enzymes by L. montana ZnONPs was competitive and non-competitive, respectively. The study outcomes revealed that the synthesised ZnONPs possessed the potential to mitigate oxidative stress and diabetes in vitro.

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Sutherlandia frutescens: The Meeting of Science and Traditional Knowledge

Cited by 31 publications

References 36 publications

Phytochemicals and botanical extracts regulate NF-κB and Nrf2/ARE reporter activities in DI TNC1 astrocytes

Phytochemicals and botanical extracts regulate NF-κB and Nrf2/ARE reporter activities in DI TNC1 astrocytes

Activities Pivotal for the Sustainability of Newly Established Technology Transfer Offices: A Case Study of Publicly Financed South African Universities

Potentials of synthesised Lessertia montana zinc oxide nanoparticles on free radicals-mediated oxidative stress and carbohydrate-hydrolysing enzymes

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