<i>Syzygium aromaticum</i>– Role in Oral Health and Dental Care

Askari, Vahid Reza; Najafi, Zohre; Rahimi, Vafa Baradaran

doi:10.1002/9781394167197.ch26

Cited by 2 publications

(1 citation statement)

References 113 publications

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“…Studies have been conducted on the metabolism and pharmacokinetics of eugenol in humans. With its diverse range of bene cial effects, eugenol holds great promise for multifaceted applications, and the development of new drugs based on its pharmacological effects can be advantageous [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of a Novel Nanofibrous Chitosan Dressing with Eugenol and Iodoform for Treating Alveolar Osteitis

Arabi,

Kamali,

Abbaspour

et al. 2024

Preprint

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Objective: Dry socket or alveolar osteitis is the most common complication following bone exposure. Alveolus, after the dissolution of the blood clot in the tooth socket, is accompanied by severe and persistent pain, bad breath, foul taste in the mouth, or localized lymphadenitis. The treatment of dry socket is based on pain relief to facilitate its healing process. One of the commonly used treatments for dry socket is Alvogyl, which is produced by combining indigenous red fibers from South Asia with active ingredients such as eugenol and iodoform. Since access to these fibers is challenging, finding a suitable alternative for this material is essential. Chitosan is a polymeric substance with remarkable antimicrobial properties and is considered safe for human consumption. On the other hand, the production of nanofibers offers desirable characteristics such as an increased surface-to-volume ratio, which, along with other advantages of chitosan use, such as availability and antimicrobial properties, justifies the necessity of this research. Methods and Materials: Based on the properties of chitosan, iodoform, and eugenol, formulations were prepared, including a drug-free formulation, a formulation containing 0.24% iodoform, 0.02% eugenol, and a formulation containing 0.24% iodoform with 0.02% eugenol, using an electrospinning apparatus to produce nanofibers. The characteristics of the polymeric solution, such as viscosity, pH, and electrical conductivity, were examined. The diameter, morphology, and diameter distribution of the nanofibers were investigated using SEM. XRD, DSC, and FT-IR tests were conducted to assess the crystalline properties and interaction of the materials. Drug delivery features, including tensile strength, drug loading, drug release profile, as well as cellular toxicity and minimum inhibitory concentration (MIC) of the nanofiber membrane, were evaluated. Results: Nanofibers were successfully prepared using the electrospinning method, with average fiber diameters of 64 ± 335 nm, 80 ± 360 nm, 97 ± 355 nm, and 59 ± 214 nm for drug-free fibers, fibers containing 0.24% iodoform, 0.02% eugenol, and fibers containing 0.24% iodoform with 0.02% eugenol, respectively. The addition of iodoform and eugenol to the polymer increased the electrical conductivity of the solution and the fibers but decreased the pH and tensile strength. The desired drug loading percentage was achieved for drug-free fibers and fibers containing 0.24% iodoform, 0.02% eugenol, and fibers containing 0.24% iodoform with 0.02% eugenol. FT-IR, DSC, and XRD analyses confirmed the absence of interactions between the drug and excipients in the polymeric membrane. According to the cellular toxicity tests conducted, none of the nanofibers exhibited cytotoxicity against fibroblast cells. Conclusion: Based on the conducted investigations, it can be concluded that iodoform and eugenol can be successfully loaded into chitosan and polyethylene oxide nanofibers. The obtained fibers possess mechanical strength and controlled drug release profiles, making them suitable for dry socket dressings, which should be further evaluated in in vivo tests.

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Section: Introductionmentioning

confidence: 99%

Development and Evaluation of a Novel Nanofibrous Chitosan Dressing with Eugenol and Iodoform for Treating Alveolar Osteitis

Arabi,

Kamali,

Abbaspour

et al. 2024

Preprint

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Development and Evaluation of Oromucosal Spray Formulation Containing Plant-Derived Compounds for the Treatment of Infectious and Inflammatory Diseases of the Oral Cavity

Maslii,

Herbina,

Dene

et al. 2024

Polymers

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According to data in the literature, natural products and essential oils are often used in dental practice. To develop a new oromucosal spray for the treatment of infectious and inflammatory diseases of the oral cavity, clove CO2 extract and essential oils of lavender and grapefruit were used as active pharmaceutical ingredients. Clove extract was obtained by the method of subcritical extraction from various raw materials, the choice of which was based on the yield of the CO2 extract and the study of its phytochemical and microbiological properties. Based on the results of microscopic and diffraction analyses, the rational time of ultrasonic exposure for the emulsion of active pharmaceutical ingredients was established. Mucoadhesive polymers were used as stabilizers of the two-phase system and prolongators. This article discusses the impact of the type and concentration of mucoadhesive polymers on the stability of the emulsion system; the viscous, textural, adhesive, and film characteristics of oromucosal spray; and the parameters determining sprayability.

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Syzygium aromaticum– Role in Oral Health and Dental Care

Cited by 2 publications

References 113 publications

Development and Evaluation of a Novel Nanofibrous Chitosan Dressing with Eugenol and Iodoform for Treating Alveolar Osteitis

Development and Evaluation of a Novel Nanofibrous Chitosan Dressing with Eugenol and Iodoform for Treating Alveolar Osteitis

Development and Evaluation of Oromucosal Spray Formulation Containing Plant-Derived Compounds for the Treatment of Infectious and Inflammatory Diseases of the Oral Cavity

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