<i>Talaromyces (Penicillium) marneffei</i>infection in non-HIV-infected patients

Chan, Jasper Fuk‐Woo; Lau, Susanna K.P.; Yuen, Kwok‐Yung; Woo, Patrick C. Y.

doi:10.1038/emi.2016.18

Cited by 207 publications

(269 citation statements)

References 113 publications

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“…1994). Nowadays the epidemiology of T. marneffei infection has changed significantly with the improved treatment of HIV, and an increasing number and proportion of cases have been reported in non-HIV-infected patients, who had other immunocompromising conditions (Tang et al., 2010, Lee et al., 2012, Lee et al., 2014, Chan et al., 2016). In our survey of indoor fungi in China we did not detect T. marneffei .…”

Section: Discussionmentioning

confidence: 99%

New Talaromyces species from indoor environments in China

Chen¹,

Sun²,

Houbraken³

et al. 2016

Studies in Mycology

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Talaromyces contains both asexual and sexually reproducing species. This genus is divided in seven sections and currently has 105 accepted species. In this study we investigated the Talaromyces isolates that were obtained during a study of indoor air collected in Beijing, China. These indoor Talaromyces strains are resolved in four sections, seven of them are identified as T. islandicus, T. aurantiacus, T. siamensis and T. albobiverticillius according to BenA sequences, while 14 isolates have divergent sequences and are described here as nine new species. The new species are placed in four sections, namely sections Helici, Islandici, Talaromyces and Trachyspermi. They are described based on sequence data (ITS, BenA, CaM and RPB2) in combination with phenotypic and extrolite characters. Morphological descriptions and notes for distinguishing similar species are provided for each new species. The recently described T. rubrifaciens is synonymised with T. albobiverticillius based on presented phylogenetic results.

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Section: Discussionmentioning

confidence: 99%

New Talaromyces species from indoor environments in China

Chen¹,

Sun²,

Houbraken³

et al. 2016

Studies in Mycology

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“…Only small proportion of disseminated T. marneffei infection occurs in patients with secondary immunodeficiencies (22, 23, 83, 84). It is otherwise rare in healthy persons, especially in children.…”

Section: Pids In Endemic Mycoses: Needles In a Haystack?mentioning

confidence: 99%

Cellular and Molecular Defects Underlying Invasive Fungal Infections—Revelations from Endemic Mycoses

Lee

Lau

2017

Front. Immunol.

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The global burden of fungal diseases has been increasing, as a result of the expanding number of susceptible individuals including people living with human immunodeficiency virus (HIV), hematopoietic stem cell or organ transplant recipients, patients with malignancies or immunological conditions receiving immunosuppressive treatment, premature neonates, and the elderly. Opportunistic fungal pathogens such as Aspergillus, Candida, Cryptococcus, Rhizopus, and Pneumocystis jiroveci are distributed worldwide and constitute the majority of invasive fungal infections (IFIs). Dimorphic fungi such as Histoplasma capsulatum, Coccidioides spp., Paracoccidioides spp., Blastomyces dermatiditis, Sporothrix schenckii, Talaromyces (Penicillium) marneffei, and Emmonsia spp. are geographically restricted to their respective habitats and cause endemic mycoses. Disseminated histoplasmosis, coccidioidomycosis, and T. marneffei infection are recognized as acquired immunodeficiency syndrome (AIDS)-defining conditions, while the rest also cause high rate of morbidities and mortalities in patients with HIV infection and other immunocompromised conditions. In the past decade, a growing number of monogenic immunodeficiency disorders causing increased susceptibility to fungal infections have been discovered. In particular, defects of the IL-12/IFN-γ pathway and T-helper 17-mediated response are associated with increased susceptibility to endemic mycoses. In this review, we put together the various forms of endemic mycoses on the map and take a journey around the world to examine how cellular and molecular defects of the immune system predispose to invasive endemic fungal infections, including primary immunodeficiencies, individuals with autoantibodies against interferon-γ, and those receiving biologic response modifiers. Though rare, these conditions provide importance insights to host defense mechanisms against endemic fungi, which can only be appreciated in unique climatic and geographical regions.

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“…In recent decades, penicilliosis has emerged in HIV-infected and other immunocompromised patients in various countries (3)(4)(5)(6). Since the disease carries a high mortality rate and is associated with relapse, finding ways to improve diagnosis and treatment is crucial (7,8).…”

mentioning

confidence: 99%

In Vitro Activity of Posaconazole against Talaromyces marneffei by Broth Microdilution and Etest Methods and Comparison to Itraconazole, Voriconazole, and Anidulafungin

Lau

Lam

et al. 2017

Antimicrob Agents Chemother

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We determined the susceptibilities of 57 Talaromyces marneffei strains to anidulafungin, itraconazole, voriconazole, and posaconazole with MICs of 2 to 8, 0.002 to 0.004, 0.016 to 0.063, and 0.001 to 0.002 g/ml by broth microdilution and Ͼ32, Յ0.002 to 0.008, Յ0.002 to 0.008, and Յ0.002 g/ml by Etest, respectively, at yeast phase; MICs at mycelial phase for anidulafungin and posaconazole were 1 to 2 and 0.004 to 0.063 g/ml, respectively. The results suggest promising activities of posaconazole. Etest can be used for testing of azoles against T. marneffei.

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Talaromyces (Penicillium) marneffeiinfection in non-HIV-infected patients

Cited by 207 publications

References 113 publications

New Talaromyces species from indoor environments in China

New Talaromyces species from indoor environments in China

Cellular and Molecular Defects Underlying Invasive Fungal Infections—Revelations from Endemic Mycoses

In Vitro Activity of Posaconazole against Talaromyces marneffei by Broth Microdilution and Etest Methods and Comparison to Itraconazole, Voriconazole, and Anidulafungin

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