<i>TBXA2R</i> gene polymorphism and responsiveness to leukotriene receptor antagonist in children with asthma

Kim, Jae-Hoon; Lee, Soo-Youn; Kim, HB; Hs, Jin; Yu, Jianping; Kim, BJ; Bs, Kim; Mj, Kang; So, Jang; Sj, Hong

doi:10.1111/j.1365-2222.2007.02874.x

Cited by 33 publications

(24 citation statements)

References 38 publications

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“…In these populations, polymorphisms in TBXA2R have been associated with asthma, atopy, asprin sensitivity, and blood levels of specific IgE (Ober and Hoffjan 2006;Kim et al 2008). We provide evidence demonstrating that TBXA2R is associated with both atopy and AHR in Caucasians ( Table 2).…”

Section: Discussionmentioning

confidence: 66%

Analyses of associations with asthma in four asthma population samples from Canada and Australia

et al. 2009

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Asthma, atopy, and related phenotypes are heterogeneous complex traits, with both genetic and environmental risk factors. Extensive research has been conducted and over hundred genes have been associated with asthma and atopy phenotypes, but many of these findings have failed to replicate in subsequent studies. To separate true associations from false positives, candidate genes need to be examined in large well-characterized samples, using standardized designs (genotyping, phenotyping and analysis). In an attempt to replicate previous associations we amalgamated the power and resources of four studies and genotyped 5,565 individuals to conduct a genetic association study of 93 previously associated candidate genes for asthma and related phenotypes using the same set of 861 single-nucleotide polymorphisms (SNPs), a common genotyping platform, and relatively harmonized phenotypes. We tested for association between SNPs and the dichotomous outcomes of asthma, atopy, atopic asthma, and airway hyperresponsiveness using a general allelic D. Daley and M. Lemire contributed equally to this manuscript. Electronic supplementary materialThe online version of this article

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Section: Discussionmentioning

confidence: 66%

Analyses of associations with asthma in four asthma population samples from Canada and Australia

et al. 2009

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“…Conflicting results about the genetic alteration of TBXA2R in the involvement of asthma have been reported in an Asian population (13)(14)(15). Genetic alteration of CRTH2 has been correlated to allergic asthma in African-American and Chinese populations (18), but not in a Japanese population (19).…”

Section: Discussionmentioning

confidence: 97%

“…TBXA 2 exerts its action, such as bronchoconstriction and bronchial hyper responsiveness (10,11), by interacting with the G protein- (13) showed a positive association between the TBXA2R polymorphism and the development of atopy and asthma. On the other hand, Kim et al (14) showed that the TBXA2R polymorphism was not associated with asthma susceptibility and the clinical parameters of asthma. In a Japanese population, Unoki et al (15) found that the synonymous +924T>C polymorphism in the TBXA2R gene was associated with a diagnosis of asthma in adult asthmatic patients, but not in children.…”

Section: Introductionmentioning

confidence: 99%

Thromboxane A2 receptor +795T>C and chemoattractant receptor-homologous molecule expressed on Th2 cells -466T>C gene polymorphisms in patients with aspirin-exacerbated respiratory disease

Kohyama¹,

Hashimoto²,

Abe³

et al. 2011

Mol Med Report

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Abstract.It is well known that aspirin-exacerbated respiratory disease (AERD) is more common in women than in men, however, whether gene polymorphisms of the thromboxane A 2 receptor (TBXA2R) and chemoattractant receptorhomologous molecules expressed on Th2 cells (CRTH2) are associated with the susceptibility of AERD remains unknown. In this study, we examined the gene polymorphisms in a Japanese population. DNA specimens were obtained from the following three groups: 96 patients with AERD, 500 patients with aspirin-tolerant asthma (ATA) and 100 normal controls. The target DNA sequence of each gene was amplified, and an allelic discrimination assay for single nucleotide polymorphisms relating to expression of each gene was carried out. The frequencies of the CC/CT genotype of TBXA2R +795T>C were higher than those of the TT genotype in AERD patients compared to ATA patients (P=0.015). In female AERD patients, but not in males, frequencies of the CC/CT genotype were higher than those of the TT genotype of TBXA2R +795T>C compared to female ATA patients (P=0.013). Also, frequencies of the TT genotype of CRTH2 -466T>C were higher than those of the CC/CT genotype in AERD patients compared to ATA patients (P=0.034). In female AERD patients, but not in male, frequencies of the TT genotype were higher than those of the CC/CT genotype of CRTH2 -466T>C in AERD patients compared to female ATA patients (P=0.046). Based on our investigations, no significant relationship was found between the genotype and the clinical characteristics according to these gene polymorphisms in AERD patients. Our results suggest that an association between the TBXA2R and CRTH2 gene polymorphisms with AERD may exist in the Japanese population.

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“…Trials of montelukast have provided variable results [45][46][47][48]. In one trial, montelukast provided measurable protection against EIB in asthma patients 15 to 44 years of age, with onset of action within 2 hours [46].…”

Section: Therapymentioning

confidence: 97%

An update on exercise-induced bronchoconstriction with and without asthma

Randolph

2009

Curr Allergy Asthma Rep

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Exercise-induced bronchoconstriction (EIB) is defined as transient, reversible bronchoconstriction that develops after strenuous exercise. It is a heterogeneous syndrome made up of a spectrum of phenotypes ranging from the asymptomatic military recruit whose condition is detected by diagnostic exercise challenge to the athlete with known asthma to the elite athlete for whom EIB represents an overuse or injury syndrome. If exercise is the only identified trigger for bronchoconstriction, it is called EIB. However, when it is associated with known asthma, then it is defined as EIB with asthma. This review discusses the pathogenesis, presentation, diagnosis, and management of EIB and EIB with asthma.

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TBXA2R gene polymorphism and responsiveness to leukotriene receptor antagonist in children with asthma

Abstract: A combined effect of TBXA2R+795T>C and +924T>C risk alleles may be linked to IgE production, eosinophilic inflammation, and severity of asthma. In addition, the TBXA2R+795T>C genotype may be a predictive marker of a clinical response to the LTRA in Korean asthmatic children with EIB.

Cited by 33 publications

References 38 publications

Analyses of associations with asthma in four asthma population samples from Canada and Australia

Analyses of associations with asthma in four asthma population samples from Canada and Australia

Thromboxane A2 receptor +795T>C and chemoattractant receptor-homologous molecule expressed on Th2 cells -466T>C gene polymorphisms in patients with aspirin-exacerbated respiratory disease

An update on exercise-induced bronchoconstriction with and without asthma

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