<i>The Cochrane Library</i> and chronic cough in children: an umbrella review

Bialy, Liza; Domino, Frank J.; Chang, Anne B.; Thomson, Denise; Becker, Lorne A

doi:10.1002/ebch.66

Cited by 7 publications

(4 citation statements)

References 34 publications

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“…The search strategy was similar to the one published in the previous version of this overview (33). The CDSR was searched using the terms 'specific cough', 'nonspecific cough', 'moist cough' and 'chronic cough' in the record title.…”

Section: Search Methods For Identification Of Reviewsmentioning

confidence: 99%

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The Cochrane Library and the Treatment of Chronic Cough in Children: An Overview of Reviews

Russell

Chang

Foisy

et al. 2010

Evid.‐Based Child Health

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BackgroundChronic cough is a universal condition of childhood that affects approximately one in ten children. Chronic cough can be either specific (‘wet’ cough or other symptoms concurrently present) or nonspecific (‘dry’ cough in the absence of other symptoms). Compared to adults, specific and non‐specific chronic cough in children differs in terms of both aetiology and treatment, and the methods used to treat chronic cough in adults may actually be harmful for children.ObjectiveThis overview of reviews synthesizes the evidence currently in the Cochrane Library Database of Systematic Reviews (CDSR) in order to answer the following question: in the treatment of childhood specific and non‐specific chronic cough, which pharmacologic or non‐pharmacologic treatments improve cough symptoms and decrease adverse events?MethodsThe Cochrane Database of Systematic Reviews was searched using the terms ‘specific cough’, ‘non‐specific cough’, ‘moist cough’ and ‘chronic cough’ in the record title for all systematic reviews examining pharmacologic or non‐pharmacologic interventions for the treatment of chronic cough in children. Data were extracted, complied into tables, and synthesized using qualitative and quantitative methods.Main ResultsSix reviews (five on non‐specific cough and one on specific cough) were indentified for inclusion. For non‐specific cough, one review found that very high‐dose inhaled corticosteroids were effective in reducing non‐specific cough (RR: 2.04; 95% CI: 1.10, 3.77), but this treatment was not advocated. To date, there is no evidence that anti‐histamines, β2 agonists, gastro‐oesophageal reflux treatments or leukotriene receptor antagonists are efficacious for the treatment of non‐specific chronic cough. For specific cough related to isolated wet cough, there was significant clinical improvement when children were treated with antibiotics (RR: 2.42; 95% CI: 1.65, 3.53). Limited data were available for adverse events associated with any of the treatment options.Authors' ConclusionsThe paucity of RCT evidence in the management of children with chronic cough is striking. Five systematic reviews on interventions for non‐specific cough do not support an empirical treatment approach. One systematic review on interventions for specific cough found some support for the use of antibiotics. Copyright © 2010 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. The Cochrane Collaboration

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Section: Search Methods For Identification Of Reviewsmentioning

confidence: 99%

“…This overview was first published in 2006 (33). Since then, four reviews have been updated, four new trials have been identified, and two new reviews have been published.…”

Section: Objectivesmentioning

confidence: 97%

The Cochrane Library and the Treatment of Chronic Cough in Children: An Overview of Reviews

Russell

Chang

Foisy

et al. 2010

Evid.‐Based Child Health

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“…9 The etiology of prolonged cough in children is wellrecognized as being different to that of adults, and the management of prolonged cough in children must, therefore, differ from the recommended management for adults. 10 The most common causes of adult cough include asthma, gastroesophageal reflux or upper airway cough syndrome (previously known as postnasal drip); however, current evidence suggests that these causes are not common in children with prolonged cough. [11][12][13] Underlying abnormalities, such as airway lesions, have been found to be prevalent in younger (preschool-aged) children; therefore, the identification of potential causes must be considered along with treatment for the cough.…”

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confidence: 99%

Evaluation of chronic cough in children aged 2 year to 12 years

Srikanth

Belavadi

2020

Int J Contemp Pediatr

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Background: Chronic cough is a common complaint in children which causes distress and affects the quality of life of parents and children. While cough may be seen as a common condition of childhood without serious consequences, ignoring a cough that may be the sole presenting symptom of an underlying illness can lead to delayed diagnosis and progression to a chronic respiratory morbidity. Aims and objectives of the study was to evaluate the specific diagnosis and prognosis of chronic cough in children aged 2 to 12 years.Methods: A prospective study was done in 100 children with chronic cough (history of cough >4 weeks) at Narayana Hospital, Nellore. Routine investigations like complete blood count with differential count, Mantoux test, sputum examination, and X ray chest and other investigations like bronchoscopy, HIV, CT scan chest and paranasal sinuses, barium swallow, endoscopy and biopsy whenever needed. Pearson Chi square test carried out to quantify significance difference, p value <0.05, considered significant.Results: The mean duration of chronic cough was 56.27 days (1-5 months). Most of the children belonged to <6 years age with higher boys’ prevalence. Breathlessness and fever noticed in 79% cases; it was found mostly in pneumonia cases as compared to other diagnosis (p=0.001). Sputum production noticed in 4, which found to be bronchiectasis. 1 case noticed with regurgitation, which is gastro oesphageal reflux disease. History of triggers for the symptoms of cough, wheeze and breathlessness is found to have a significant correlation with asthma (p=0.000). Asthma in 14% of cases, of which 12 were mild persistent and 2 were moderate persistent. Tuberculosis was diagnosed in 14% cases, Pneumonia in 12% cases, and Bronchiectasis in 12 cases. Undernourished children noticed in 56%, maximum number in tuberculosis group. Asthma was associated with pneumonia, mucous plug obstruction and collapse lung. Recurrent pneumonia was associated with airway anomaly, gastro esophageal reflux disease.Conclusions: It should be remembered that a prolonged cough can be indicative of a more serious underlying condition, and always warrants thorough investigation.

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“…Bisher gibt es solche Arbeiten z. B. aus der Kinderheilkunde[5], auch eine eigene Besprechung zur Fettleberhepatitis folgte diesem Prinzip[6]. Es ist geplant, dass Umbrella-Reviews zu einem festen Bestandteil der Cochrane Library werden.…”

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Die Cochrane Library - eine Einführung für Gastroenterologen

Timmer¹,

Motschall²

2007

Z Gastroenterol

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The Cochrane Library and chronic cough in children: an umbrella review

Cited by 7 publications

References 34 publications

The Cochrane Library and the Treatment of Chronic Cough in Children: An Overview of Reviews

The Cochrane Library and the Treatment of Chronic Cough in Children: An Overview of Reviews

Evaluation of chronic cough in children aged 2 year to 12 years

Die Cochrane Library - eine Einführung für Gastroenterologen

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