The responses of single cells in the central nucleus of the inferior colliculus of the rat were studied with characteristic frequency tones amplitude modulated by pseudorandom noise or sinusoidal waveforms, in order to investigate the degree to which these responses can be described by a linear model. When pseudorandom noise was used as the modulating waveform, period histograms of the response locked to the periodicity of the noise were cross-correlated with a single period of the noise. The response of a model, having this cross-correlogram as its impulse response and the pseudorandom noise sequence as the input waveform, differed in appearance from the corresponding period histogram of the neural discharges, indicating that the latter contained a non-negligible, nonlinear component.Further manipulation of the data showed that the most significant nonlinearities were of even order, which indicates that the changes in neural discharge rate to increments and decrements in stimulus intensity are asymmetrical. In some units, particularly at low mean stimulus intensities, this was clearly evident as a halfwave rectification of the period histogram. The magnitude of the modulation of the period histograms increased as a function of the sound intensity for some units, while in others it decreased; in still other units the magnitude of the modulation of the neural discharges was relatively constant over a large range of stimulus intensities. When the modulation transfer functions were estimated from the responses to noise-modulated sounds they were found to be very similar to those obtained using sinusoidally modulated sound, despite large degrees of nonlinearity being present in the responses to both types of sound.inferior colliculus, amplitude modulation, pseudorandom noise, model simulation
IntraductionThe presence of temporal variations of amplitude and frequency may play an important role in the perception of speech and other complex auditory signals. Our understanding of how these signals are encoded and processed at the neuronal level is relatively sparse, particularly where the central nuclei of the auditory pathway are concerned. We have recently undertaken a study of the responses of single neurons in the inferior colliculus of the rat to amplitude-modulated (AM) stimuli. These results are described in two companion papers which are concerned with the stimulus properties which govern the response to AM (e.g., mean intensity, modulation frequency) and the underlying topographical organization within the colliculus for AM responses (Rees and Moller, 1987a,b). The stimuli employed in these studies were chiefly tones and noise amplitude modulated by pseudorandom noise sequences from which estimates of the modulation sensitivity were derived by linear systems analysis.As an introduction to these studies the present paper describes, with the aid of a model, the extent to which this method provides a full description of the responses of inferior colliculus neurons to AM, and compares the estimates of modulation s...