The New England Journal of Medicineand the Massachusetts Medical Society

Neoplasias del tracto genitourinario: historia de los grandes avances

“…Desde entonces, la prueba de concepto quedó grabada en la historia de la oncología, las sales de platino pasaron a ser parte fundamental del esquema terapéutico en tumores germinales y de aquí en adelante por aproximadamente 45 años, los ensayos clínicos con medicamentos en este escenario, se basaron en variar las medicamentos asociados en la combinación al platino (17,18), intentar regímenes de altas dosis de quimioterapia con soporte de progenitores de células hematopoyéticas, agregado de mejores antieméticos, para intentar disminuir los efectos tóxicos y rescatar a pacientes de alto riesgo que progresan al régimen estándar (19,20).…”

The Evolving Roles of the Medical Journal

“…In 1921, it was sold to the Massachusetts Medical Society for $1 -though the purchase provided more stability than the price suggests. Competition remained keen in 1921, with more than 5000 medical journals "descending like locusts on the land" (1952). And it intensified over the century, as general journals begat specialty journals, subspecialty journals, single-subject journals .…”

“…The dissemination by journals of new research results in pathophysiology and therapeutics demonstrates the changing ways in which medical knowledge is produced. In the Journal's early de cades, original research contributions from American physicians couldn't fill even a quarterly, according to Joseph Garland (1952). The editors supplemented research with reviews of books, conferences, and other journals and presented French and German scholarship (conducting literally "translational" medicine).…”

“…Joseph Garland, who oversaw the Journal's expansion into an international forum, believed that journals and their editorials need not "necessarily be confined to topics related to medicine, so long as they are ones in which the reader has or might have an interest" (1952). Subsequent editors have concurred, arguing that editorial decisions must "take into account philosophy, politics, economics, pedagogy and other social aspects of health care" (1977) and that medical journals must include "exposure and discussion of important issues that involve, even indirectly, health and medicine" (1999a).…”

Broodings on the APHA Analysis of the Proposed F.Y. 1976 Federal Budget for Health

“…"Original writing," as another editor has said, "like tapping a maple tree, is a tedious business, but the really slow work and the hard sugar come in the boiling down of the sap." 6 The Journal's purpose as the organ of a society remains to be addressed. Four During an economic recession it is customary, furthermore, to interweave pro forma remarks on the "serious fiscal crisis" and the need "to make some very hard decisions regarding allocation of limited financial resources."…”